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Mathematical models of bone externally excited remodelling

Total Cost €


EC-Contrib. €






Project "MMoBEER" data sheet

The following table provides information about the project.


Organization address
address: NEWPORT ROAD 30-36
postcode: CF24 ODE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-11-02   to  2019-11-01


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 195˙454.00


 Project objective

For describing complex systems as bone tissue, with their inner interactions and their interactions with environment the mathematical models become even more complex, that puts demands on theories, methods and assumptions used and the efficiency of numerical methods employed for solving as well as the management of data. The complexity of bone models depends not only on the number of parameters describing different biochemistry and Multi-physics influences but also on different time scales and rate of periodicity of processes involved. In structural analysis non-linearity plays important role for realistic description of real world phenomena. Incorporated the parametric nonlinear analysis of periodically excited hybrid systems into a structural models of bone would be a great advantages for prediction of a more realistic situation for description of the bone mass distribution, delay in the osteoblasts and osteoclasts coupling, osteocytes transferring of signals and more other issues related to the bone adaptively and strength. The aim of the project would be that on the base of existing level of known parameters in bone turnover guided by external loading provide an analytical approach to be solve and interpreted for real description and prediction of bone adaptive behavior. Hybrid systems treat cellular level as discrete system of particles described with system of coupled ordinary differential equations and environmental conditions as a continuous system described with a system of coupled partial differential equations affected with different external signals. The established, measured and explored model will also give an approach closer to the realistic situation and real needs and suggestions for patients with bone problems but also for those who want to have healthy and strong skeleton.


year authors and title journal last update
List of publications.
2020 Julijana Simonovic
Mathematical Modelling of Externally Excited Bone Remodeling
published pages: 78-81, ISSN: 2632-4067, DOI:
The Project Repository Journal (PRj) Jan 2020 – Volume 4 2020-02-12
2019 Simonovic Julijana
Mathematical commentary of external excitation in bone cell population models
published pages: , ISSN: , DOI:
EMBL/EMBO Symposium- Mechanical Forces in Development 2-6 July 2019 EMBL/EMBO Symposium- Mechanical 2020-01-30
2019 Simonovic Julijana and Woolley Thomas
Study of bone cell population models of s-system type
published pages: , ISSN: , DOI:
Organ-on-a-Chip Technologies Network – Learning and Collaborative Event on 8 April 2019 Organ-on-a-Chip Technologies Ne 2020-01-30
2019 Simonovic Julijana
Bone cell population models and their advantages: simplicity, purposefulness and exactness
published pages: , ISSN: , DOI:
JRC Summer School on Non-Animal Approaches in Science – Challenges and Future Directions, Italy, 21-24 May 2019 JRC Summer School on Non-Animal 2020-01-30
2019 Simonovic Julijana and Hedrih Katica
Amplitude resonant jumps in transient regimes of complex structure oscillation
published pages: 27, ISSN: , DOI:
Abstract Book. International Conference on Nonlinear Solid Mechanics 16-19 June 2019. ICoNSoM 2019 2020-01-30
2019 Simonovic Julijana, Holt Cathy and Mason Deborah
Semantic insight and behaviour of the computational bone cell population models
published pages: , ISSN: , DOI:
25th Congress of the European Society of Biomechanics (ESB 2019), 7-10 July 2019 25th Congress of the European S 2020-01-30
2019 Simonovic Julijana and Woolley Thomas
Equation of osteocyte activity in the bone cell population model
published pages: , ISSN: , DOI:
ACTC Advances in Cell and Tissue Cultures 4-5th June 2019 ACTC Advances in Cell and Tissu 2020-01-30

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The information about "MMOBEER" are provided by the European Opendata Portal: CORDIS opendata.

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