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Cost and benefit of beta-lactam resistance in Streptococcus pneumoniae: interplay between the resistance determinants and the cell elongation/division components

Total Cost €


EC-Contrib. €






 StreptoMANIAC project word cloud

Explore the words cloud of the StreptoMANIAC project. It provides you a very rough idea of what is the project "StreptoMANIAC" about.

pbp2b    strains    mutations    oral    vaccines    roles    unaffected    enzyme    acquisition    little    threat    cavities    effect    pg    listed    combination    last    emergence    transpeptidase    lactam    components    mechanisms    pneumoniae    penicillin    pneumonia    peptidoglycan    enzymes    majority    leaving    fill    drive    discovery    pbp    peripheral    resistance    biosynthesis    biochemical    media    altered    drug    pneumococcus    pbp2x    children    positive    beta    despite    genomics    normal    gram    pbp1a    function    health    nasal    affinity    sinusitis    streptococcus    techniques    bacteremia    play    elderly    cytological    binding    mutated    conferring    constitutes    wall    whereas    public    primarily    pbps    benefit    resistant    antibiotics    acquired    resident    isolates    young    advantage    otitis    clinical    serious    meningitis    stages    gaps    solely    genetic    regulate    proteins    domain    cell    modified    global    six    pathogens    lactams    concentrated    mediated    ciarh    scenario    division    multiple   

Project "StreptoMANIAC" data sheet

The following table provides information about the project.


Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 183˙473.00


 Project objective

The widespread emergence of acquired resistance to antibiotics constitutes a serious threat to global public health. Among Gram-positive pathogens, Streptococcus pneumoniae (the pneumococcus) is a normal resident of the oral and nasal cavities but is also cause of otitis media and sinusitis as well as pneumonia, bacteremia and meningitis, particularly in young children and the elderly. Despite the availability of effective vaccines, S. pneumoniae remains an important clinical problem, also because of the increase of multi-drug resistant clinical isolates. S. pneumoniae is, indeed, listed by the WHO as one of the priority pathogens to drive research, discovery and development of new antibiotics. In S. pneumoniae, resistance to beta-lactam antibiotics represents a highly complex scenario, involving both target enzymes, the penicillin-binding proteins (PBPs), and non-PBP components, as the two-component system CiaRH. In clinical isolates, beta-lactam resistance is primarily mediated by the acquisition of multiple mutations in the transpeptidase domain of three of its six PBPs: PBP2x, PBP2b and PBP1a. These modified PBPs have reduced affinity for beta-lactams while leaving the enzyme function unaffected, thus conferring an advantage for the mutated strains in the presence of the antibiotics. However, PBPs are not only the beta-lactam target but are also essential enzymes involved the last stages of peptidoglycan biosynthesis, where they play specific roles in peripheral (side-wall) growth and cell division. Whereas the majority of studies so far concentrated solely on the effect of altered PBPs on resistance, little is known about the impact of the altered PBPs on PG biosynthesis, cell growth and division. Using a combination of genetic, biochemical, cytological and comparative genomics techniques, this study aims to fill in the knowledge gaps in the cost and benefit of acquired beta-lactam resistance in S. pneumoniae and in the complex mechanisms that regulate it.

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The information about "STREPTOMANIAC" are provided by the European Opendata Portal: CORDIS opendata.

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