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StreptoMANIAC SIGNED

Cost and benefit of beta-lactam resistance in Streptococcus pneumoniae: interplay between the resistance determinants and the cell elongation/division components

Total Cost €

0

EC-Contrib. €

0

Partnership

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 StreptoMANIAC project word cloud

Explore the words cloud of the StreptoMANIAC project. It provides you a very rough idea of what is the project "StreptoMANIAC" about.

antibiotics    pneumoniae    gaps    young    affinity    discovery    mutated    otitis    whereas    pneumococcus    peptidoglycan    biochemical    streptococcus    solely    concentrated    biosynthesis    bacteremia    pbp2x    threat    components    normal    pathogens    pneumonia    last    transpeptidase    children    meningitis    scenario    techniques    positive    modified    fill    serious    pbps    listed    health    combination    constitutes    cavities    lactams    despite    enzymes    pg    roles    primarily    ciarh    mechanisms    conferring    mutations    play    peripheral    cell    regulate    altered    emergence    mediated    media    function    enzyme    genomics    global    sinusitis    elderly    majority    six    pbp1a    stages    resident    binding    wall    cytological    pbp2b    unaffected    nasal    acquired    acquisition    little    genetic    clinical    leaving    domain    drug    pbp    gram    vaccines    beta    multiple    resistance    lactam    advantage    penicillin    resistant    public    isolates    oral    effect    drive    division    proteins    benefit    strains   

Project "StreptoMANIAC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI TRENTO 

Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122
website: www.unitn.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 183˙473.00

Map

 Project objective

The widespread emergence of acquired resistance to antibiotics constitutes a serious threat to global public health. Among Gram-positive pathogens, Streptococcus pneumoniae (the pneumococcus) is a normal resident of the oral and nasal cavities but is also cause of otitis media and sinusitis as well as pneumonia, bacteremia and meningitis, particularly in young children and the elderly. Despite the availability of effective vaccines, S. pneumoniae remains an important clinical problem, also because of the increase of multi-drug resistant clinical isolates. S. pneumoniae is, indeed, listed by the WHO as one of the priority pathogens to drive research, discovery and development of new antibiotics. In S. pneumoniae, resistance to beta-lactam antibiotics represents a highly complex scenario, involving both target enzymes, the penicillin-binding proteins (PBPs), and non-PBP components, as the two-component system CiaRH. In clinical isolates, beta-lactam resistance is primarily mediated by the acquisition of multiple mutations in the transpeptidase domain of three of its six PBPs: PBP2x, PBP2b and PBP1a. These modified PBPs have reduced affinity for beta-lactams while leaving the enzyme function unaffected, thus conferring an advantage for the mutated strains in the presence of the antibiotics. However, PBPs are not only the beta-lactam target but are also essential enzymes involved the last stages of peptidoglycan biosynthesis, where they play specific roles in peripheral (side-wall) growth and cell division. Whereas the majority of studies so far concentrated solely on the effect of altered PBPs on resistance, little is known about the impact of the altered PBPs on PG biosynthesis, cell growth and division. Using a combination of genetic, biochemical, cytological and comparative genomics techniques, this study aims to fill in the knowledge gaps in the cost and benefit of acquired beta-lactam resistance in S. pneumoniae and in the complex mechanisms that regulate it.

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