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Cost and benefit of beta-lactam resistance in Streptococcus pneumoniae: interplay between the resistance determinants and the cell elongation/division components

Total Cost €


EC-Contrib. €






 StreptoMANIAC project word cloud

Explore the words cloud of the StreptoMANIAC project. It provides you a very rough idea of what is the project "StreptoMANIAC" about.

solely    threat    function    bacteremia    lactams    drive    beta    resident    oral    pneumonia    stages    mechanisms    pneumococcus    peptidoglycan    young    pneumoniae    public    peripheral    enzymes    normal    biochemical    emergence    last    acquired    listed    meningitis    binding    regulate    lactam    wall    pbp2x    positive    despite    primarily    constitutes    leaving    techniques    pbp2b    pbp1a    little    gram    mutations    resistant    concentrated    streptococcus    conferring    penicillin    children    serious    advantage    isolates    whereas    scenario    ciarh    roles    otitis    clinical    cell    genomics    resistance    gaps    proteins    altered    biosynthesis    six    multiple    drug    acquisition    pbp    enzyme    discovery    media    domain    modified    fill    combination    pathogens    vaccines    play    majority    division    elderly    mutated    affinity    pbps    unaffected    pg    antibiotics    strains    components    sinusitis    effect    health    benefit    cytological    cavities    genetic    transpeptidase    global    nasal    mediated   

Project "StreptoMANIAC" data sheet

The following table provides information about the project.


Organization address
address: VIA CALEPINA 14
city: TRENTO
postcode: 38122

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2021-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) coordinator 183˙473.00


 Project objective

The widespread emergence of acquired resistance to antibiotics constitutes a serious threat to global public health. Among Gram-positive pathogens, Streptococcus pneumoniae (the pneumococcus) is a normal resident of the oral and nasal cavities but is also cause of otitis media and sinusitis as well as pneumonia, bacteremia and meningitis, particularly in young children and the elderly. Despite the availability of effective vaccines, S. pneumoniae remains an important clinical problem, also because of the increase of multi-drug resistant clinical isolates. S. pneumoniae is, indeed, listed by the WHO as one of the priority pathogens to drive research, discovery and development of new antibiotics. In S. pneumoniae, resistance to beta-lactam antibiotics represents a highly complex scenario, involving both target enzymes, the penicillin-binding proteins (PBPs), and non-PBP components, as the two-component system CiaRH. In clinical isolates, beta-lactam resistance is primarily mediated by the acquisition of multiple mutations in the transpeptidase domain of three of its six PBPs: PBP2x, PBP2b and PBP1a. These modified PBPs have reduced affinity for beta-lactams while leaving the enzyme function unaffected, thus conferring an advantage for the mutated strains in the presence of the antibiotics. However, PBPs are not only the beta-lactam target but are also essential enzymes involved the last stages of peptidoglycan biosynthesis, where they play specific roles in peripheral (side-wall) growth and cell division. Whereas the majority of studies so far concentrated solely on the effect of altered PBPs on resistance, little is known about the impact of the altered PBPs on PG biosynthesis, cell growth and division. Using a combination of genetic, biochemical, cytological and comparative genomics techniques, this study aims to fill in the knowledge gaps in the cost and benefit of acquired beta-lactam resistance in S. pneumoniae and in the complex mechanisms that regulate it.

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The information about "STREPTOMANIAC" are provided by the European Opendata Portal: CORDIS opendata.

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