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SECRET SIGNED

Exploitation of the SECRETory pathway for cancer therapy to address European research

Total Cost €

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EC-Contrib. €

0

Partnership

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 SECRET project word cloud

Explore the words cloud of the SECRET project. It provides you a very rough idea of what is the project "SECRET" about.

aberrant    mutual    motility    trove    cancers    invasion    esrs    incomplete    broadly    treatment    coordinated    therapies    stuttgart    secret    therapy    secretory    microenvironment    underpinning    19    approved    career    triple    crc    diagnostic    serve    subgroup    selective    metastasis    industry    therapeutic    university    colorectal    strategies    regulated    presentation    chemotherapy    contributes    treasure    biology    beneficiaries    promise    medicine    tnbc    translational    intersectoral    poor    dysregulated    activation    15    accounting    polarity    training    metastases    platform    talented    train    infancy    progression    negative    prognosis    limited    academia    breast    interrogate    interdisciplinary    regulation    patients    driver    secretion    holds    hallmarks    hyperproliferation    tumor    option    bc    cell    applicable    inspire    prone    deaths    11    proteins    shaping    death    countries    resistance    drive    frequent    evasion    cancer    altered    suppression    signaling    purposes    rates    secretome   

Project "SECRET" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET STUTTGART 

Organization address
address: KEPLERSTRASSE 7
city: STUTTGART
postcode: 70174
website: www.uni-stuttgart.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙955˙339 €
 EC max contribution 3˙955˙339 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET STUTTGART DE (STUTTGART) coordinator 758˙365.00
2    UNIVERSITETET I OSLO NO (OSLO) participant 584˙684.00
3    STICHTING VUMC NL (AMSTERDAM) participant 531˙239.00
4    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 292˙342.00
5    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 264˙207.00
6    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 263˙500.00
7    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 261˙499.00
8    CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH DE (FREIBURG) participant 252˙788.00
9    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 252˙788.00
10    ANAXOMICS BIOTECH SL ES (BARCELONA) participant 250˙904.00
11    PROTATOUANS - ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA PERIORISMENIS EYTHINIS EL (GLYFADA) participant 243˙017.00

Map

 Project objective

Breast and colorectal cancer (BC and CRC) are the most frequent cancers accounting for 19% of all deaths from cancer in Europe. In case of triple-negative BC (TNBC) targeted therapies are not available and non-selective chemotherapy is the only treatment option. Targeted therapy has been approved for the treatment of advanced CRC, but response rates are low and treatment is limited to a subgroup of patients. Also, TNBC and CRC patients are prone to develop metastases and have a poor prognosis underpinning the need for new targeted and broadly applicable therapeutic strategies. Tumor cell secretion contributes to hallmarks of cancer e.g. hyperproliferation, evasion of growth suppression, loss of cell polarity, activation of cell motility, invasion and metastasis, shaping of the tumor microenvironment through altered presentation of proteins and the secretome, and resistance to cell death. Dysregulated secretion is thus a driver of cancer progression and therefore holds promise as a general therapeutic target for the treatment of cancers. However, strategies to exploit the secretory pathway for therapeutic and diagnostic purposes are still in their infancy due to the incomplete understanding of how this pathway is regulated by aberrant signaling. The overall research objective of SECRET is to drive the understanding of the mutual regulation of the secretory pathway and signaling in cancer, which will serve as a platform to identify and interrogate novel diagnostic and therapeutic strategies. SECRET comprises 11 beneficiaries and 7 partner organizations from 9 countries. Coordinated by the University of Stuttgart, SECRET will train 15 talented ESRs in the field of translational cancer systems cell biology and systems medicine towards a career in industry or academia through a highly interdisciplinary and intersectoral research training programme and inspire them to exploit the SECRETory pathway as a treasure trove to design novel therapeutic strategies against cancer.

 Publications

year authors and title journal last update
List of publications.
2019 Olayioye, Noll, Hausser
Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases
published pages: 1478, ISSN: 2073-4409, DOI: 10.3390/cells8121478
Cells 8/12 2020-04-08

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The information about "SECRET" are provided by the European Opendata Portal: CORDIS opendata.

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