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SECRET SIGNED

Exploitation of the SECRETory pathway for cancer therapy to address European research

Total Cost €

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EC-Contrib. €

0

Partnership

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SECRET project word cloud

Explore the words cloud of the SECRET project. It provides you a very rough idea of what is the project "SECRET" about.

bc chemotherapy signaling polarity drive rates poor coordinated mutual biology diagnostic subgroup training treatment therapy regulation translational breast inspire progression trove holds incomplete strategies activation proteins intersectoral approved regulated infancy suppression 19 deaths secretory secretome resistance university promise interdisciplinary underpinning beneficiaries treasure dysregulated triple 15 therapies stuttgart patients shaping aberrant microenvironment applicable limited contributes 11 broadly crc purposes colorectal secret platform altered countries invasion tumor medicine hallmarks tnbc hyperproliferation selective prognosis academia cancers cancer evasion prone esrs accounting metastasis serve industry train death secretion talented metastases motility career negative option cell frequent therapeutic driver interrogate presentation

Project "SECRET" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET STUTTGART Organization address address: KEPLERSTRASSE 7 city: STUTTGART postcode: 70174 website: www.uni-stuttgart.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	3˙955˙339 €
EC max contribution	3˙955˙339 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2019
Funding Scheme	MSCA-ITN-ETN
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2023-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET STUTTGART UNIVERSITAET STUTTGART Organization address address: KEPLERSTRASSE 7 city: STUTTGART postcode: 70174 website: www.uni-stuttgart.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	coordinator	758˙365.00
2	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	584˙684.00
3	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	531˙239.00
4	OSLO UNIVERSITETSSYKEHUS HF OSLO UNIVERSITETSSYKEHUS HF Organization address address: KIRKEVEIEN 166 TARNBYGGET city: OSLO postcode: 450 website: http://www.oslo-universitetssykehus.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	292˙342.00
5	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	264˙207.00
6	TEL AVIV UNIVERSITY TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	263˙500.00
7	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	261˙499.00
8	CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH Organization address address: AM FLUGHAFEN 12-14 city: FREIBURG postcode: 79108 website: http://www.charlesriver.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	252˙788.00
9	UNIVERSITAETSKLINIKUM FREIBURG UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	252˙788.00
10	ANAXOMICS BIOTECH SL ANAXOMICS BIOTECH SL Organization address address: CALLE DIPUTACIO 237, P 1 PTA 1 city: BARCELONA postcode: 8007 website: www.anaxomics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	250˙904.00
11	PROTATOUANS - ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA PERIORISMENIS EYTHINIS PROTATOUANS - ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA PERIORISMENIS EYTHINIS Organization address address: ODOS NAVARCHOU VOTSI 3 city: GLYFADA postcode: 16675 website: www.protATonce.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (GLYFADA)	participant	243˙017.00

Map

Project objective

Breast and colorectal cancer (BC and CRC) are the most frequent cancers accounting for 19% of all deaths from cancer in Europe. In case of triple-negative BC (TNBC) targeted therapies are not available and non-selective chemotherapy is the only treatment option. Targeted therapy has been approved for the treatment of advanced CRC, but response rates are low and treatment is limited to a subgroup of patients. Also, TNBC and CRC patients are prone to develop metastases and have a poor prognosis underpinning the need for new targeted and broadly applicable therapeutic strategies. Tumor cell secretion contributes to hallmarks of cancer e.g. hyperproliferation, evasion of growth suppression, loss of cell polarity, activation of cell motility, invasion and metastasis, shaping of the tumor microenvironment through altered presentation of proteins and the secretome, and resistance to cell death. Dysregulated secretion is thus a driver of cancer progression and therefore holds promise as a general therapeutic target for the treatment of cancers. However, strategies to exploit the secretory pathway for therapeutic and diagnostic purposes are still in their infancy due to the incomplete understanding of how this pathway is regulated by aberrant signaling. The overall research objective of SECRET is to drive the understanding of the mutual regulation of the secretory pathway and signaling in cancer, which will serve as a platform to identify and interrogate novel diagnostic and therapeutic strategies. SECRET comprises 11 beneficiaries and 7 partner organizations from 9 countries. Coordinated by the University of Stuttgart, SECRET will train 15 talented ESRs in the field of translational cancer systems cell biology and systems medicine towards a career in industry or academia through a highly interdisciplinary and intersectoral research training programme and inspire them to exploit the SECRETory pathway as a treasure trove to design novel therapeutic strategies against cancer.

Publications

List of publications.
year	authors and title	journal	last update
2019	Olayioye, Noll, Hausser Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases published pages: 1478, ISSN: 2073-4409, DOI: 10.3390/cells8121478	Cells 8/12	2020-04-08

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