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SECRET SIGNED

Exploitation of the SECRETory pathway for cancer therapy to address European research

Total Cost €

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EC-Contrib. €

0

Partnership

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 SECRET project word cloud

Explore the words cloud of the SECRET project. It provides you a very rough idea of what is the project "SECRET" about.

proteins    negative    regulation    secretome    secretory    contributes    poor    polarity    shaping    industry    metastases    holds    hyperproliferation    presentation    promise    15    motility    purposes    dysregulated    esrs    translational    intersectoral    drive    activation    death    resistance    accounting    crc    evasion    approved    talented    trove    inspire    underpinning    metastasis    career    11    cancers    beneficiaries    stuttgart    triple    coordinated    limited    regulated    treasure    suppression    microenvironment    progression    prone    infancy    mutual    driver    diagnostic    deaths    therapy    train    strategies    hallmarks    therapeutic    aberrant    rates    academia    therapies    selective    biology    training    cell    subgroup    bc    prognosis    university    breast    altered    colorectal    option    incomplete    frequent    signaling    applicable    treatment    broadly    tnbc    secret    invasion    chemotherapy    platform    interdisciplinary    serve    19    secretion    medicine    countries    patients    cancer    tumor    interrogate   

Project "SECRET" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET STUTTGART 

Organization address
address: KEPLERSTRASSE 7
city: STUTTGART
postcode: 70174
website: www.uni-stuttgart.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 3˙955˙339 €
 EC max contribution 3˙955˙339 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2019
 Funding Scheme MSCA-ITN-ETN
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET STUTTGART DE (STUTTGART) coordinator 758˙365.00
2    UNIVERSITETET I OSLO NO (OSLO) participant 584˙684.00
3    STICHTING VUMC NL (AMSTERDAM) participant 531˙239.00
4    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 292˙342.00
5    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 264˙207.00
6    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 263˙500.00
7    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 261˙499.00
8    CHARLES RIVER DISCOVERY RESEARCH SERVICES GERMANY GMBH DE (FREIBURG) participant 252˙788.00
9    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 252˙788.00
10    ANAXOMICS BIOTECH SL ES (BARCELONA) participant 250˙904.00
11    PROTATOUANS - ETAIREIA EREYNAS VIOTECHNOLOGIAS MONOPROSOPI ETAIREIA PERIORISMENIS EYTHINIS EL (GLYFADA) participant 243˙017.00

Map

 Project objective

Breast and colorectal cancer (BC and CRC) are the most frequent cancers accounting for 19% of all deaths from cancer in Europe. In case of triple-negative BC (TNBC) targeted therapies are not available and non-selective chemotherapy is the only treatment option. Targeted therapy has been approved for the treatment of advanced CRC, but response rates are low and treatment is limited to a subgroup of patients. Also, TNBC and CRC patients are prone to develop metastases and have a poor prognosis underpinning the need for new targeted and broadly applicable therapeutic strategies. Tumor cell secretion contributes to hallmarks of cancer e.g. hyperproliferation, evasion of growth suppression, loss of cell polarity, activation of cell motility, invasion and metastasis, shaping of the tumor microenvironment through altered presentation of proteins and the secretome, and resistance to cell death. Dysregulated secretion is thus a driver of cancer progression and therefore holds promise as a general therapeutic target for the treatment of cancers. However, strategies to exploit the secretory pathway for therapeutic and diagnostic purposes are still in their infancy due to the incomplete understanding of how this pathway is regulated by aberrant signaling. The overall research objective of SECRET is to drive the understanding of the mutual regulation of the secretory pathway and signaling in cancer, which will serve as a platform to identify and interrogate novel diagnostic and therapeutic strategies. SECRET comprises 11 beneficiaries and 7 partner organizations from 9 countries. Coordinated by the University of Stuttgart, SECRET will train 15 talented ESRs in the field of translational cancer systems cell biology and systems medicine towards a career in industry or academia through a highly interdisciplinary and intersectoral research training programme and inspire them to exploit the SECRETory pathway as a treasure trove to design novel therapeutic strategies against cancer.

 Publications

year authors and title journal last update
List of publications.
2019 Olayioye, Noll, Hausser
Spatiotemporal Control of Intracellular Membrane Trafficking by Rho GTPases
published pages: 1478, ISSN: 2073-4409, DOI: 10.3390/cells8121478
Cells 8/12 2020-04-08

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The information about "SECRET" are provided by the European Opendata Portal: CORDIS opendata.

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