Opendata, web and dolomites

DREAM SIGNED

The Brainstem-Hippocampus Network Uncovered: Dynamics, Reactivation and Memory Consolidation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "DREAM" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 174˙167 €
 EC max contribution 174˙167 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 174˙167.00

Map

 Project objective

Storing information and then using it to guide behaviour is one of the most remarkable abilities of the brain. Memory storage relies on network mechanisms in which the hippocampal formation interacts with the rest of the brain during periods of sleep. The neural computations associated with this process correlate with both enduring and transient changes in the excitability of neural circuits. Nuclei located in the brainstem dictate these ‘state changes’, modulating the signalling between groups of forebrain cells. However, the role of the brainstem in memory formation remains unknown. This project aims to determine the role of different sleep stages in memory formation and long-term consolidation, and to elucidate the functional role of the brainstem in these processes. To this end, I will use a battery of experimental techniques, mathematical methods and biophysical models to probe and analyse the neural activity of the brainstem-hippocampal system. Neuronal activity will be recorded concurrently from the pons, thalamus and hippocampus of mice while performing a reference memory task. I will identify specific neural mechanisms that trigger different hippocampal synchrony regimes and memory reactivations mediated by brainstem activity during wakefulness and sleep. For this, I will develop state-of-the-art methods based on signal processing and machine learning. Besides, using optogenetic tools, I will determine the causal role of the brainstem in regulating hippocampal circuits and the animals’ behavioural performance. Finally, I will develop a biophysical model to test how well different network mechanisms explain the dynamics of the interactions between the brainstem and the hippocampus. Understanding the detailed properties of the interactions between these systems of the brain in relation to memory processes will be an important step toward establishing neurophysiological markers that can be preventive targets to ameliorate effects of memory-related pathologies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DREAM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DREAM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

POSPORI (2019)

Polymer Optical Sensors for Prolonged Overseeing the Robustness of civil Infrastructures

Read More  

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

ASSEMBLY (2019)

Advancing Synthethic Supramolecular chemical biology

Read More