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FreeATPOC SIGNED

Towards an instrument-free future of molecular diagnostics at the point-of-care

Total Cost €

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EC-Contrib. €

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Partnership

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 FreeATPOC project word cloud

Explore the words cloud of the FreeATPOC project. It provides you a very rough idea of what is the project "FreeATPOC" about.

started    quantitative    applicability    blood    outbreaks    acids    sophisticated    disadvantage    enzymatically    extremely    assay       time    uv    market    regulated    ambient    sensitive    free    restriction    groups    slow    molecular    substantial    divided    latter    simplicity    final    demonstrated    colorimetric    former    infrastructure    combines    temperature    modules    point    advantages    immuno    interestingly    translation    vision    influenza    ultra    societal    adoption    monitoring    failures    kits    min    benefits    heaters    complexity    ing    limited    tools    poor    lab    patient    gaining    disease    advantage    plant    genetic    pathogens    newly    acid    sensitivities    infectious    electricity    enzymes    spreading    human    models    takes    enzymatic    resource    samples    swabs    instrument    paper    poc    generation    global    clinically    ligases    polymerases    revolutionize    care    instruments    tissues    amplification    primarily    technologies    xylella    smartphone    big    utility    combined    combination    predictive    accompanied    amplified    maintenance    economic    nucleic    hiv    fastidiosa    diagnostic    diagnostics    detection    expand   

Project "FreeATPOC" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Total cost 3˙052˙500 €
 EC max contribution 3˙052˙500 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 1˙146˙250.00
2    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 640˙000.00
3    GNOSIS DATA ANALYSIS IDIOTIKI KEFALAIOUCHIKI ETAIREIA EL (HERAKLION) participant 515˙000.00
4    UNIVERSITY COLLEGE LONDON HOSPITALSNHS FOUNDATION TRUST UK (LONDON) participant 401˙250.00
5    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 350˙000.00

Map

 Project objective

Molecular diagnostics is still primarily a lab-based method. Emerging technologies for application at the point of care (POC) or need, i.e., where a patient or a sample is, have started gaining a big part of the molecular diagnostics market. Interestingly, available methods are divided in two groups: sophisticated instruments for ultra-sensitive temperature-regulated enzymatic amplification of nucleic acids and extremely simple paper-based immuno-diagnostic kits. Complexity, the main disadvantage of the former, results in their poor translation to several applications at the POC. Simplicity, often accompanied by failures, of the latter is the reason for their slow adoption even in resource limited areas. Our vision is an instrument-free approach that combines the advantages of both groups, i.e., a method that does not use heaters or modules that require electricity, infrastructure and maintenance, but, still, takes advantage of enzymatically-amplified nucleic acids detection. To achieve the above, novel diagnostic tools for genetic amplification based on ligases, polymerases and restriction enzymes operating at ambient temperature will be developed, combined with quantitative smartphone colorimetric/UV detection. The global applicability of the new approach will be demonstrated during infectious disease (Influenza and HIV) testing in human samples (blood and swabs) and plant pathogens (Xylella fastidiosa) in plant-tissues. In all cases, we aim for a time-to-result of less than 60 min, demonstrated sensitivities down to the clinically/field relevant values and a final cost in the order of $1 per assay. Combination of Free@POC concept with newly developed predictive models will expand its utility to monitoring disease outbreaks and their spreading. This new generation of instrument-free molecular diagnostics is expected to revolutionize nucleic acid analysis at the POC but also in applications beyond resulting in substantial societal as well as economic benefits.

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The information about "FREEATPOC" are provided by the European Opendata Portal: CORDIS opendata.

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