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DimorphicCircuits SIGNED

Elucidating the development of sexually-dimorphic circuits: from molecular mechanisms to synapses and behavior

Total Cost €

EC-Contrib. €

Partnership

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DimorphicCircuits project word cloud

Explore the words cloud of the DimorphicCircuits project. It provides you a very rough idea of what is the project "DimorphicCircuits" about.

environmental transcriptome pursue diseases rewire sexual mapped connectome aid impose resolved nematode gender seek labeling females dimorphisms differently males complementary demonstrated missing neurons edge shed map traits transform preliminary reproducing light molecular phenotypes cutting therapies building connection elusive generate sensory input basis optogenetics circuits reveal entire cell complete avoidance function aversive lab identity mechanism repertoire sexes elegans shared stimuli behavior single dimorphic neuronal neural difference manner elucidate imaging nervous receive cues sexually belonging individual circuit synaptic underlying screens dynamics behaviors genetic dependent mechanisms biased mediated species connectivity sex calcium genes neurological modulates trans dimension

Project "DimorphicCircuits" data sheet

The following table provides information about the project.

Coordinator	WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2019-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-10-01 to 2024-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	coordinator	1˙500˙000.00

Map

Project objective

In sexually reproducing species, males and females respond to environmental sensory cues and transform the input into sexually dimorphic traits. These dimorphisms are the basis for sex-biased phenotypes in many neurological diseases. Yet, complete understanding of the underlying mechanism is still missing. How does the sexual identity impose molecular changes to individual neurons and circuits? What are the sex-specific synaptic changes that occur during development in these circuits? We recently demonstrated a sexually dimorphic dimension of neuronal connectivity: neurons belonging to a shared nervous system rewire in a sex-specific manner to generate sexually dimorphic behaviors. New findings from our lab further reveal a significant difference in the way the two sexes in the nematode C. elegans respond to aversive stimuli. These dimorphic responses are mediated via sex-shared circuits that receive similar environmental input, yet respond differently. Building on our exciting preliminary results, we seek to elucidate how genetic sex modulates neuronal function, neural circuit dynamics and behavior during development. This proposal will pursue three complementary objectives: (i) Map the repertoire of sexually dimorphic avoidance behaviors; (ii) Study the synaptic basis for the development of sexually dimorphic circuits; and (iii) Elucidate the molecular basis of sexually dimorphic neuronal circuits. These mechanisms can only be currently resolved in C. elegans, where the entire connectome of the nervous system for both sexes has been mapped. Using cutting-edge optogenetics, calcium imaging, activity-dependent trans-synaptic labeling, genetic screens and single-cell transcriptome analysis we will shed light on the elusive connection between genes, circuits and behavior. Understanding how genetic sex modulates neuronal circuits will aid in the development of novel gender-specific therapies.

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The information about "DIMORPHICCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.