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DimorphicCircuits SIGNED

Elucidating the development of sexually-dimorphic circuits: from molecular mechanisms to synapses and behavior

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DimorphicCircuits project word cloud

Explore the words cloud of the DimorphicCircuits project. It provides you a very rough idea of what is the project "DimorphicCircuits" about.

transform    species    identity    mechanism    neuronal    therapies    aversive    complementary    single    connectivity    missing    imaging    basis    building    stimuli    manner    mapped    cues    labeling    edge    function    genes    molecular    dimorphisms    males    gender    sexual    diseases    cutting    modulates    sexes    demonstrated    individual    optogenetics    sexually    nervous    impose    map    repertoire    neurons    complete    trans    transcriptome    light    circuit    mechanisms    aid    behaviors    shared    dimension    connection    dynamics    neurological    traits    pursue    lab    avoidance    differently    mediated    elucidate    circuits    dimorphic    neural    difference    elusive    females    sensory    calcium    resolved    screens    reveal    generate    entire    rewire    connectome    nematode    dependent    synaptic    genetic    underlying    input    receive    preliminary    seek    behavior    biased    shed    phenotypes    belonging    cell    reproducing    elegans    sex    environmental   

Project "DimorphicCircuits" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

Map

 Project objective

In sexually reproducing species, males and females respond to environmental sensory cues and transform the input into sexually dimorphic traits. These dimorphisms are the basis for sex-biased phenotypes in many neurological diseases. Yet, complete understanding of the underlying mechanism is still missing. How does the sexual identity impose molecular changes to individual neurons and circuits? What are the sex-specific synaptic changes that occur during development in these circuits? We recently demonstrated a sexually dimorphic dimension of neuronal connectivity: neurons belonging to a shared nervous system rewire in a sex-specific manner to generate sexually dimorphic behaviors. New findings from our lab further reveal a significant difference in the way the two sexes in the nematode C. elegans respond to aversive stimuli. These dimorphic responses are mediated via sex-shared circuits that receive similar environmental input, yet respond differently. Building on our exciting preliminary results, we seek to elucidate how genetic sex modulates neuronal function, neural circuit dynamics and behavior during development. This proposal will pursue three complementary objectives: (i) Map the repertoire of sexually dimorphic avoidance behaviors; (ii) Study the synaptic basis for the development of sexually dimorphic circuits; and (iii) Elucidate the molecular basis of sexually dimorphic neuronal circuits. These mechanisms can only be currently resolved in C. elegans, where the entire connectome of the nervous system for both sexes has been mapped. Using cutting-edge optogenetics, calcium imaging, activity-dependent trans-synaptic labeling, genetic screens and single-cell transcriptome analysis we will shed light on the elusive connection between genes, circuits and behavior. Understanding how genetic sex modulates neuronal circuits will aid in the development of novel gender-specific therapies.

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The information about "DIMORPHICCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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