Cell2Cell SIGNED
What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the Cell2Cell project. It provides you a very rough idea of what is the project "Cell2Cell" about.
Project "Cell2Cell" data sheet
The following table provides information about the project.
| Coordinator |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 3˙889˙769 € |
| EC max contribution | 3˙889˙769 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2019 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-11-01 to 2023-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN | DE (MUENCHEN) | coordinator | 1˙011˙153.00 |
| 2 | HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH | DE (NEUHERBERG) | participant | 505˙576.00 |
| 3 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | participant | 303˙172.00 |
| 4 | KAROLINSKA INSTITUTET | SE (STOCKHOLM) | participant | 281˙982.00 |
| 5 | SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT | CH (Basel) | participant | 281˙276.00 |
| 6 | INSTITUT CURIE | FR (PARIS) | participant | 274˙802.00 |
| 7 | STICHTING KATHOLIEKE UNIVERSITEIT | NL (NIJMEGEN) | participant | 265˙619.00 |
| 8 | WEIZMANN INSTITUTE OF SCIENCE | IL (REHOVOT) | participant | 263˙500.00 |
| 9 | INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES | PT (LISBOA) | participant | 237˙720.00 |
| 10 | EPIGENETIKS GENETIK BIYOINFORMATIK YAZILIM AS | TR (ISTANBUL) | participant | 235˙248.00 |
| 11 | CELLSORTER MUSZAKI KUTATO ES FEJLESZTO KFT | HU (BUDAPEST) | participant | 229˙715.00 |
Map
Project objective
Infectious diseases kill millions of people worldwide every year. Decades of research have revealed important insights into the molecular mechanisms pathogens employ to establish lasting infections, yet little is known about what renders individual pathogens within a microbial population more successful at establishing an infection than others. Recent advances in single-cell technologies have started to revolutionize modern biology, unveiling an enormous degree of cell-to-cell heterogeneity. Often, phenotypic variability is not caused by genetic changes in the DNA sequence, but by epigenetic changes in the structural organization of DNA called chromatin. In multicellular organisms, this epigenetic plasticity plays a key role in developmental processes and cancer. In unicellular pathogens, cell-to-cell heterogeneity is hypothesized to promote the establishment of infections by allowing the pathogen to adapt to changing environments or evade the host immune response. To decrease the burden of infectious diseases, it is therefore, necessary to better understand how infections are enabled by cellular heterogeneity at the chromatin level of the pathogen. Several limitations have previously challenged this endeavor, including small genome size (i.e. low signal-to-noise) and the lack of knowledge of how chromatin is organized in pathogens. Cell2Cell proposes to overcome these barriers by bringing together (1) experts in pathogen biology; (2) the use of unicellular yeast species to serve as chromatin models; (3) single-cell technologies; (4) bioinformatics tools. Using state of the art technologies, we will train early stage researchers to identify the molecular mechanisms that control cell-to-cell heterogeneity in pathogens. The proposed research will contribute to the elucidation of how heterogeneity affects the outcome of diseases and give rise to highly skilled scientists that are well prepared to face the demands of modern genomics research in academia and industry.
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