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DEVMEM SIGNED

Learning to remember: the development of the neural mechanisms supporting memory processing.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DEVMEM project word cloud

Explore the words cloud of the DEVMEM project. It provides you a very rough idea of what is the project "DEVMEM" about.

understand    memories    memory    mechanism    sleep    placed    ontogenesis    accounts    adulthood    expression    mechanisms    experimental    interactions    encoding    infantile    circuits    adults    influences    photon    relies    neural    powerful    of    outlined    striatal    density    circuit    flexible    couple    born    impairments    technologies    critically    emergence    spatial    recollect    interference    functioning    events    recording    imagine    function    networks    hippocampal    orchestrating    manipulation    ontogeny    retrieval    explore    describing    representations    rapid    delivered    birthday    electrophysiology    organisms    vivo    amnesia    imaging    signalling    emerged    store    delineate    emphasis    consolidation    healthy    placing    deficit    remember    source    data    tracking    planning    generally    mnemonic    weakness    rat    brain    rats    adaptive    form    lack    centred    extensive    gap    chemogenetic    frontal    neuronal    adult    hippocampus    underlying    forgetting    insights    plan   

Project "DEVMEM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙520 €
 EC max contribution 1˙999˙520 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙999˙520.00

Map

 Project objective

The ability to form and store memories allows organisms to learn from the past and imagine the future: it is a crucial mechanism underlying flexible and adaptive behaviour. The aim of this proposal is to identify the circuit mechanisms underlying our ability to learn and remember, by tracking the ontogenesis of memory processing. Importantly, we are not born with a fully functioning memory system: generally, adults cannot recollect any events from before their third birthday (‘infantile amnesia’). There are several accounts as to the source of this mnemonic deficit, each placing emphasis on impairments of specific processes (encoding, consolidation, retrieval). However, a general weakness in the study of memory ontogeny is the lack of neural data describing the activity of memory-related circuits during development. To directly address this knowledge gap, we propose to study the ontogeny of brain-wide hippocampus-centred memory networks in the rat. We will study to which extent memory expression relies on spatial signalling, delineate the role of sleep in memory consolidation, determine how hippocampal planning-related neuronal activity influences memory processing, understand whether the rapid forgetting observed in development is due to interference, and explore interactions between the hippocampus, pre-frontal and striatal circuits in orchestrating memory emergence. We are best placed to deliver this ambitious experimental plan due to our extensive experience of in vivo recording in developing rats which we will couple with the application of recently emerged technologies (2-photon imaging, high density electrophysiology, chemogenetic manipulation of neural activity). As our studies of the development of hippocampal spatial representations have delivered powerful insights into their adult function, we expect the work outlined here to critically advance our understanding not only of development, but also of healthy memory processing in adulthood.

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The information about "DEVMEM" are provided by the European Opendata Portal: CORDIS opendata.

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