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DEVMEM SIGNED

Learning to remember: the development of the neural mechanisms supporting memory processing.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DEVMEM project word cloud

Explore the words cloud of the DEVMEM project. It provides you a very rough idea of what is the project "DEVMEM" about.

influences    critically    organisms    adaptive    accounts    infantile    mechanism    placing    sleep    events    neural    electrophysiology    spatial    mechanisms    powerful    imaging    of    experimental    outlined    rat    explore    ontogenesis    data    orchestrating    emerged    memory    density    tracking    brain    store    manipulation    expression    hippocampus    ontogeny    interactions    healthy    source    deficit    consolidation    emphasis    encoding    imagine    circuits    lack    networks    vivo    impairments    couple    retrieval    chemogenetic    recollect    recording    understand    form    technologies    hippocampal    neuronal    generally    frontal    photon    signalling    extensive    weakness    forgetting    gap    remember    circuit    rats    describing    birthday    centred    flexible    adult    mnemonic    amnesia    planning    emergence    interference    underlying    function    memories    functioning    rapid    adults    placed    delineate    relies    delivered    insights    plan    striatal    representations    adulthood    born   

Project "DEVMEM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙520 €
 EC max contribution 1˙999˙520 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙999˙520.00

Map

 Project objective

The ability to form and store memories allows organisms to learn from the past and imagine the future: it is a crucial mechanism underlying flexible and adaptive behaviour. The aim of this proposal is to identify the circuit mechanisms underlying our ability to learn and remember, by tracking the ontogenesis of memory processing. Importantly, we are not born with a fully functioning memory system: generally, adults cannot recollect any events from before their third birthday (‘infantile amnesia’). There are several accounts as to the source of this mnemonic deficit, each placing emphasis on impairments of specific processes (encoding, consolidation, retrieval). However, a general weakness in the study of memory ontogeny is the lack of neural data describing the activity of memory-related circuits during development. To directly address this knowledge gap, we propose to study the ontogeny of brain-wide hippocampus-centred memory networks in the rat. We will study to which extent memory expression relies on spatial signalling, delineate the role of sleep in memory consolidation, determine how hippocampal planning-related neuronal activity influences memory processing, understand whether the rapid forgetting observed in development is due to interference, and explore interactions between the hippocampus, pre-frontal and striatal circuits in orchestrating memory emergence. We are best placed to deliver this ambitious experimental plan due to our extensive experience of in vivo recording in developing rats which we will couple with the application of recently emerged technologies (2-photon imaging, high density electrophysiology, chemogenetic manipulation of neural activity). As our studies of the development of hippocampal spatial representations have delivered powerful insights into their adult function, we expect the work outlined here to critically advance our understanding not only of development, but also of healthy memory processing in adulthood.

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The information about "DEVMEM" are provided by the European Opendata Portal: CORDIS opendata.

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