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DEVMEM SIGNED

Learning to remember: the development of the neural mechanisms supporting memory processing.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DEVMEM project word cloud

Explore the words cloud of the DEVMEM project. It provides you a very rough idea of what is the project "DEVMEM" about.

hippocampus    orchestrating    rats    placing    emphasis    emergence    amnesia    sleep    striatal    store    insights    centred    underlying    remember    mechanisms    consolidation    recollect    critically    extensive    impairments    of    networks    neural    signalling    adults    delivered    chemogenetic    encoding    brain    relies    circuits    manipulation    explore    placed    memories    generally    vivo    rapid    healthy    influences    hippocampal    born    photon    imagine    organisms    source    emerged    powerful    birthday    retrieval    technologies    imaging    interactions    lack    rat    recording    weakness    describing    interference    infantile    plan    data    frontal    spatial    events    planning    gap    accounts    electrophysiology    ontogeny    adaptive    forgetting    adult    tracking    neuronal    memory    function    couple    outlined    mnemonic    circuit    flexible    mechanism    deficit    expression    representations    delineate    experimental    understand    form    adulthood    functioning    ontogenesis    density   

Project "DEVMEM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙520 €
 EC max contribution 1˙999˙520 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2025-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 1˙999˙520.00

Map

 Project objective

The ability to form and store memories allows organisms to learn from the past and imagine the future: it is a crucial mechanism underlying flexible and adaptive behaviour. The aim of this proposal is to identify the circuit mechanisms underlying our ability to learn and remember, by tracking the ontogenesis of memory processing. Importantly, we are not born with a fully functioning memory system: generally, adults cannot recollect any events from before their third birthday (‘infantile amnesia’). There are several accounts as to the source of this mnemonic deficit, each placing emphasis on impairments of specific processes (encoding, consolidation, retrieval). However, a general weakness in the study of memory ontogeny is the lack of neural data describing the activity of memory-related circuits during development. To directly address this knowledge gap, we propose to study the ontogeny of brain-wide hippocampus-centred memory networks in the rat. We will study to which extent memory expression relies on spatial signalling, delineate the role of sleep in memory consolidation, determine how hippocampal planning-related neuronal activity influences memory processing, understand whether the rapid forgetting observed in development is due to interference, and explore interactions between the hippocampus, pre-frontal and striatal circuits in orchestrating memory emergence. We are best placed to deliver this ambitious experimental plan due to our extensive experience of in vivo recording in developing rats which we will couple with the application of recently emerged technologies (2-photon imaging, high density electrophysiology, chemogenetic manipulation of neural activity). As our studies of the development of hippocampal spatial representations have delivered powerful insights into their adult function, we expect the work outlined here to critically advance our understanding not only of development, but also of healthy memory processing in adulthood.

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The information about "DEVMEM" are provided by the European Opendata Portal: CORDIS opendata.

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