Explore the words cloud of the SIOMICS project. It provides you a very rough idea of what is the project "SIOMICS" about.
The following table provides information about the project.
THE FRANCIS CRICK INSTITUTE LIMITED
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-04-01 to 2019-03-31|
Take a look of project's partnership.
|1||THE FRANCIS CRICK INSTITUTE LIMITED||UK (LONDON)||coordinator||195˙454.00|
Recently, multi-omics approaches have led to a plethora of publications describing in detail the ‘omics landscapes of common cancer types. However, at the bulk tissue level, integrating different ‘omics layers remains an uncompleted challenge. Soft tissue sarcomas are rare and often aggressive cancers of mesenchymal origin representing ~1% of all cancers but encompassing at least 50 subtypes. Hence, collecting enough of these rare samples for significant findings in a timely fashion is the biggest hurdle. This issue can be addressed by repeating observations within individual patients to generate new hypotheses. Our long-term collaboration aims to obtain the genome, transcriptome and methylome of each of 1,000 single-cells from 10 individual subtypes of soft tissue sarcomas. This design is possible thanks to DNA & RNA single-cell sequencing (SCS) of the same cell in Dr. Voet’s lab, and bespoke computational analyses in Dr. Van Loo’s lab, and access to this rare material of Prof. Flanagan, lead for the sarcoma component of the Genomics England 100,000 Genomes Project. This proposal is the pilot project, where we focus on one malignant peripheral nerve sheath tumour, a rare aggressive cancer originating from the connective tissues surrounding nerves. We will also sequence multiple regions of the primary tumour, the blood, and cell-free tumour DNA (ctDNA) before surgery and subsequently every three months. Prof. Flanagan’s group will process the samples, and Dr. Voet will oversee the sequencing. In Dr. Van Loo’s lab, I will develop the computational tools to uncover the 3 ‘omics signals at the single-cell level that are averaged out in bulk tissues. SCS will shed light on the fundamental links between cancer genomic subclones and the transcriptional and epigenetic diversity of cancer cell types; and we will answer whether ctDNA reflects the diversity of cancer cells and how it evolves in the course of treatment.
|year||authors and title||journal||last update|
Matthew W. Fittall, William Mifsud, Nischalan Pillay, Hongtao Ye, Anna-Christina Strobl, Annelien Verfaillie, Jonas Demeulemeester, Lei Zhang, Fitim Berisha, Maxime Tarabichi, Matthew D. Young, Elena Miranda, Patrick S. Tarpey, Roberto Tirabosco, Fernanda Amary, Agamemnon E. Grigoriadis, Michael R. Stratton, Peter Van Loo, Cristina R. Antonescu, Peter J. Campbell, Adrienne M. Flanagan, Sam Behjati
Recurrent rearrangements of FOS and FOSB define osteoblastoma
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04530-z
|Nature Communications 9/1||2019-09-06|
Christopher D. Steele, Maxime Tarabichi, Dahmane Oukrif, Amy P. Webster, Hongtao Ye, Matthew Fittall, Patrick Lombard, IÃ±igo Martincorena, Patrick S. Tarpey, Grace Collord, Kerstin Haase, Sandra J. Strauss, Fitim Berisha, Heli Vaikkinen, Pawan Dhami, Marnix Jansen, Sam Behjati, M. Fernanda Amary, Roberto Tirabosco, Andrew Feber, Peter J. Campbell, Ludmil B. Alexandrov, Peter Van Loo, Adrienne M. Flanagan, Nischalan Pillay
Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways
published pages: 441-456.e8, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2019.02.002
|Cancer Cell 35/3||2019-09-06|
Maxime Tarabichi, IÃ±igo Martincorena, Moritz Gerstung, Armand M. Leroi, Florian Markowetz, Paul T. Spellman, Quaid D. Morris, Ole Christian LingjÃ¦rde, David C. Wedge, Peter Van Loo
Neutral tumor evolution?
published pages: 1630-1633, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0258-x
|Nature Genetics 50/12||2019-09-06|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SIOMICS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "SIOMICS" are provided by the European Opendata Portal: CORDIS opendata.
Focal volume Control Using Structured Illumination SourcesRead More
How other minds are represented in the human brain: Neural computations underlying Theory of MindRead More
Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. ElegansRead More