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DyNAmecs SIGNED

Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development

Total Cost €

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EC-Contrib. €

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Partnership

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 DyNAmecs project word cloud

Explore the words cloud of the DyNAmecs project. It provides you a very rough idea of what is the project "DyNAmecs" about.

ing    wave    mechanisms    silencing    regulation    functions    protein    silent    genomes    occurs    transitions    locus    mark    model    zdbf2    lifelong    pluripotent    commitment    mammalian    gain    fertilization    genetics    once    largely    combinatorial    window    mouse    first    previously    cells    genes    undergoes    embryogenesis    cell    embryonic    ascertain    editing    embryo    canonical    tools    proteomics    strive    precision    repetitive    phenotype    de    recapitulates    profound    minority    paradigm    gametic    stays    group    polycomb    primed    mice    week    undergo    clear    antagonism    proteins    dramatic    genome    modification    division    reprogramming    genomics    gene    programmed    life    effect    reshaping    faithfully    repression    immediately    fails    human    zygote    lineage    dna    ultimately    novo    exhibit    epigenetic    methylation    erased    repercussions    utilize    patterns    plan    deposited    activation    vivo    epigenome    employ    latent    insights    ripple    coding    events    exemplified   

Project "DyNAmecs" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙495˙480 €
 EC max contribution 1˙495˙480 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙495˙480.00

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 Project objective

Immediately after fertilization, mammalian genomes undergo a dramatic reshaping of the epigenome as the embryo transitions from the zygote into the pluripotent cells primed for lineage commitment. This is best exemplified by DNA methylation reprogramming, as the gametic patterns are largely erased, and the embryonic genome undergoes a wave of de novo DNA methylation. Moreover, once DNA methylation patterns are established, mechanisms faithfully maintain the mark across cell division. Thus, there is latent potential for DNA methylation deposited in the early embryo to exhibit a lifelong effect. DNA methylation is a modification that is typically associated with gene repression at repetitive elements and at a minority of protein coding genes. I previously described the regulation of the Zdbf2 gene in mice, which is programmed during the de novo DNA methylation program. Challenging the paradigm, in this case DNA methylation is required for activation of a gene via antagonism of the polycomb-group of silencing proteins. If the DNA methylation fails to occur, the gene stays silent throughout life, resulting in a reduced growth phenotype. For my proposed research I will utilize both a cell-based system that recapitulates these early embryonic events as well as an in vivo mouse model to investigate the extent and mechanisms of non-canonical DNA methylation functions. I plan to use a combinatorial approach of genomics, genetics, and proteomics in order to ascertain novel insights into DNA methylation-based regulation. Furthermore, I plan to employ precision epigenome editing tools to address the locus-specific impact of DNA methylation. Ultimately, I strive to gain a clear understanding of the profound epigenetic consequences of DNA methylation on this window of development, which occurs in the first week of mouse embryogenesis, and the second of human, but the repercussions of which can ripple throughout life.

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The information about "DYNAMECS" are provided by the European Opendata Portal: CORDIS opendata.

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