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DyNAmecs SIGNED

Early embryonic events, life-long consequences: DNA methylation dynamics in mammalian development

Total Cost €

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EC-Contrib. €

0

Partnership

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 DyNAmecs project word cloud

Explore the words cloud of the DyNAmecs project. It provides you a very rough idea of what is the project "DyNAmecs" about.

repercussions    mammalian    de    pluripotent    human    protein    latent    utilize    exemplified    plan    paradigm    repression    tools    editing    combinatorial    coding    reshaping    fertilization    strive    immediately    precision    cell    programmed    genomes    division    events    gametic    genes    zdbf2    ing    canonical    mechanisms    genome    clear    patterns    mice    embryo    effect    dramatic    cells    methylation    window    locus    insights    lineage    undergo    profound    exhibit    reprogramming    wave    deposited    dna    embryogenesis    occurs    fails    recapitulates    commitment    erased    gain    ascertain    primed    zygote    minority    undergoes    lifelong    model    life    epigenetic    week    activation    previously    stays    functions    proteomics    mark    epigenome    modification    novo    ripple    first    transitions    genomics    mouse    silent    vivo    repetitive    antagonism    largely    silencing    faithfully    genetics    gene    regulation    phenotype    employ    once    embryonic    group    polycomb    ultimately    proteins   

Project "DyNAmecs" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙495˙480 €
 EC max contribution 1˙495˙480 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙495˙480.00

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 Project objective

Immediately after fertilization, mammalian genomes undergo a dramatic reshaping of the epigenome as the embryo transitions from the zygote into the pluripotent cells primed for lineage commitment. This is best exemplified by DNA methylation reprogramming, as the gametic patterns are largely erased, and the embryonic genome undergoes a wave of de novo DNA methylation. Moreover, once DNA methylation patterns are established, mechanisms faithfully maintain the mark across cell division. Thus, there is latent potential for DNA methylation deposited in the early embryo to exhibit a lifelong effect. DNA methylation is a modification that is typically associated with gene repression at repetitive elements and at a minority of protein coding genes. I previously described the regulation of the Zdbf2 gene in mice, which is programmed during the de novo DNA methylation program. Challenging the paradigm, in this case DNA methylation is required for activation of a gene via antagonism of the polycomb-group of silencing proteins. If the DNA methylation fails to occur, the gene stays silent throughout life, resulting in a reduced growth phenotype. For my proposed research I will utilize both a cell-based system that recapitulates these early embryonic events as well as an in vivo mouse model to investigate the extent and mechanisms of non-canonical DNA methylation functions. I plan to use a combinatorial approach of genomics, genetics, and proteomics in order to ascertain novel insights into DNA methylation-based regulation. Furthermore, I plan to employ precision epigenome editing tools to address the locus-specific impact of DNA methylation. Ultimately, I strive to gain a clear understanding of the profound epigenetic consequences of DNA methylation on this window of development, which occurs in the first week of mouse embryogenesis, and the second of human, but the repercussions of which can ripple throughout life.

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The information about "DYNAMECS" are provided by the European Opendata Portal: CORDIS opendata.

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