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NoBiasFluors SIGNED

Non-biased fluorescent dyes as markers of drugs for optical in cellulo and in vivo imaging

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NoBiasFluors project word cloud

Explore the words cloud of the NoBiasFluors project. It provides you a very rough idea of what is the project "NoBiasFluors" about.

18f    mechanism    infrared    solution    academic    pi    clinical    transfer    consisting    positive    disease    confirm    pet    extended    positron    anticancer    of    conjugation    replace    atom    biomolecules    usually    compatible    assays    binders    delivers    drug    elaborated    detectable    optical    single    operative    accurate    red    molecular    labeled    markers    imaging    fluorescent    labeling    emission    safety    structure    breakthrough    data    harmful    lectins    monitoring    ideally    cellulo    peptides    confirmation    environment    radioactive    polarity    critical    nucleopeptides    cell    negative    majority    intrinsic    representative    medium    humans    discovery    advantage    tomography    mice    interdisciplinary    moieties    near    drugs    marker    intersectoral    alzheimer    charge    careful    optimization    dyes    easily    suffers    sized    teams    radioactivity    action    vivo    applicability    prodrugs    small    despite    limits    weight    biased    nobiasfluors    dye    industrial    alkylaminoferrocene   

Project "NoBiasFluors" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG 

Organization address
address: SCHLOSSPLATZ 4
city: ERLANGEN
postcode: 91054
website: www.uni-erlangen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 699˙200 €
 EC max contribution 671˙600 € (96%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG DE (ERLANGEN) coordinator 133˙400.00
2    LIMITED LIABILITY SCIENTIFIC SERVICE COMPANY OTAVA UA (KYIV) participant 230˙000.00
3    INSTITUTUL DE CHIMIE MACROMOLECULARA PETRU PONI RO (IASI) participant 142˙600.00
4    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 92˙000.00
5    NAUKOVO VYROBNICHYJ KOOPERATYV LECTINOTEST UA (LVIV) participant 73˙600.00
6    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

Imaging of distribution of drugs in mice delivers accurate information for confirmation that the mechanism of action elaborated in cell-based assays is also operative in vivo. These data are critical for the transfer of drug discovery process from pre-clinical to clinical phase. To enable the imaging, drugs should be labeled with easily detectable moieties, e.g. radioactive markers and fluorescent dyes. Ideally, the markers should not affect in vivo properties of the drugs that can be better achieved with radioactive markers, since they can be selected to be small: e.g. a single atom marker 18F applied in positron emission tomography. Despite this intrinsic advantage, PET suffers from safety issues, since radioactivity is harmful to humans and environment. In terms of safety optical imaging is much better and, therefore, in future can replace PET. However, fluorescent dyes compatible with the optical imaging are usually extended pi-systems carrying overall positive or negative charge. Their conjugation strongly affects properties of the majority of medium sized and low molecular weight drugs that limits the applicability of this method in drug discovery. The interdisciplinary and intersectoral consortium NoBiasFluors consisting of 4 academic and 2 industrial teams aims at achieving a breakthrough solution of this problem. We will develop non-biased red and near infrared fluorescent dyes, which are compatible with in vivo optical imaging and do not affect properties of drugs upon their conjugation. This goal will be achieved by the careful optimization of dye structure, polarity and charge. We will confirm the functionality of the developed dyes for labeling of representative drugs (anticancer N-alkylaminoferrocene-based prodrugs, D-peptides targeting Alzheimer’s disease) and binders of biomolecules (nucleopeptides and lectins) and monitoring their distribution both in cellulo and in vivo (for a selected labeled drug).

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