SYNBIO.ECM SIGNED
SYNBIO.ECM: Designer extracellular matrices to program healthy and diseased cardiac morphogenesis
Total Cost €
0EC-Contrib. €
0Partnership
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0SYNBIO.ECM project word cloud
Explore the words cloud of the SYNBIO.ECM project. It provides you a very rough idea of what is the project "SYNBIO.ECM" about.
Project "SYNBIO.ECM" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI PAVIA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 1˙999˙375 € |
| EC max contribution | 1˙999˙375 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-07-01 to 2025-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITA DEGLI STUDI DI PAVIA | IT (PAVIA) | coordinator | 1˙999˙375.00 |
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Project objective
To meet medical needs worldwide, tissue engineering must move from successful pre/clinical products towards an effective process to meet Worldwide medical needs, but this is challenging since a quantitative design framework has not emerged, yet. Synthetic biology (SYNBIO) was the solution that genetic engineers found to the same problem: “Despite tremendous individual successes in genetic engineering and biotechnology […], why is the engineering of useful synthetic biological systems still an expensive, unreliable and ad hoc research process?” asked Dr. Endy in a 2005 letter to Nature. The SYNBIO solution included: i) libraries of DNA parts with well-characterized effect on cells; ii) tools to computationally design system-level assemblies, or designer-DNA; and, iii) bottom-up engineering of cell functions using progressively more complex designer-DNA. Effectively, SYNBIO introduced a computer-aided design and manufacturing (CAD/M) platform that transformed the process of engineering cells. However, since inputs from the extracellular matrix (ECM) have largely been ignored, progress towards programmable tissue-level behavior have been more modest.
Here, we will build on my experience with computational and experimental models in cardiac tissue engineering to develop a CAD/M framework for engineering cardiac tissues with computationally predictable properties, or designer-ECM. To characterize ECM-cell interactions, we will use traction force and super-resolution microscopy with fluorescence in-situ sequencing. To model multiscale ECM-cell interactions, we will use ordinary differential equations and subcellular element models. Finally, we will leverage ECM parts and human induced pluripotent stem cells to bioprint designer-ECM that recapitulate three phases of heart development: trabeculation, compaction, and maturation.
With synthetic matrix biology (SYNBIO.ECM), we will develop a CAD/M-based process and a new class of products for cardiac tissue engineering.
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The information about "SYNBIO.ECM" are provided by the European Opendata Portal: CORDIS opendata.