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Bio-TUNE SIGNED

Fine tune of cellular behavior: multifunctional materials for medical implants

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Bio-TUNE project word cloud

Explore the words cloud of the Bio-TUNE project. It provides you a very rough idea of what is the project "Bio-TUNE" about.

reduce    favor    life    catastrophic    coatings    adhesion    innovative    functions    generation    selective    host    understand    combined    cell    materials    multifunctional    medicine    biofilm    levels    biomaterial    physiological    hence    tend    technological    ideally    ambitions    active    unmet    effect    implants    bio    paradigms    cytotoxic    science    bacteria    accepted    introduces    simultaneously    majority    tissues    personalized    medical    inhibit    positively    cells    interaction    biomaterials    subsequent    surfaces    frequently    eukaryotic    colonization    tissue    biomimetic    antibacterial    patterns    seek    clinical    transfer    patient    instructive    mechanistic    compromising    efforts    generate    biointegration    surrounding    implant    biophysical    tune    either    biomolecular    decipher    competition    mitigate    biochemical    infection    rarely    treatments    healthcare    quality    topographically    bacterial    agents    devoted    explore    topographical    regeneration    mindset    representing    preventing    significantly   

Project "Bio-TUNE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT POLITECNICA DE CATALUNYA 

Organization address
address: CALLE JORDI GIRONA 31
city: BARCELONA
postcode: 8034
website: www.upc.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 814˙200 €
 EC max contribution 814˙200 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT POLITECNICA DE CATALUNYA ES (BARCELONA) coordinator 216˙200.00
2    UNIVERSITA DEGLI STUDI DI CAMERINO IT (CAMERINO) participant 211˙600.00
3    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 110˙400.00
4    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 110˙400.00
5    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 87˙400.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 78˙200.00
7    GADJAH MADA UNIVERSITY ID (YOGYAKARTA) partner 0.00
8    UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN AR (SAN MARTIN BUENOS AIRES) partner 0.00
9    UNIVERSIDAD PERUANA DE CIENCIAS APLICADAS SAC PE (LIMA) partner 0.00
10    UNIVERSITI SAINS MALAYSIA* MY (PENANG) partner 0.00

Map

 Project objective

Bio-TUNE aims to develop innovative multifunctional materials to produce a new generation of medical implants with cell instructive and antibacterial potential.

In biomaterials science, it is well accepted that implant biointegration with surrounding tissues is a major goal. However, implant surfaces that facilitate cell adhesion, may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can be catastrophic and significantly reduce patient quality of life, representing an emerging concern in healthcare.

On the other hand, research efforts devoted to inhibit bacterial colonization are frequently related to cytotoxic agents or treatments that do not positively affect host tissues. Hence, ideally, to enhance the long-term success of medical implants, biomaterial surfaces should reduce bacterial colonization levels without compromising the physiological functions of eukaryotic cells. Yet, the majority of current approaches tend to only focus on either improving cell adhesion or preventing bacterial infection but rarely explore a combined effect.

In Bio-TUNE we focus on multifunctional coatings to simultaneously address and mitigate both these problems. Thus, Bio-TUNE introduces a new mindset and different paradigms in the development of biomaterials to respond to unmet clinical needs.

Bio-TUNE ambitions to 1) Study and understand the interaction of eukaryotic cells with bacteria at the biophysical and biomolecular level; 2) To develop cell instructive and antibacterial surfaces via biochemical and topographical approaches; 3) Transfer this technology to medical implants.

We seek to decipher the mechanistic of eukaryotic and bacterial cell competition, generate new selective and multi-potential coatings and topographically-active patterns, and their technological transfer leading to a generation of advanced biomimetic materials for tissue regeneration and personalized medicine.

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The information about "BIO-TUNE" are provided by the European Opendata Portal: CORDIS opendata.

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