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Bio-TUNE SIGNED

Fine tune of cellular behavior: multifunctional materials for medical implants

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Bio-TUNE project word cloud

Explore the words cloud of the Bio-TUNE project. It provides you a very rough idea of what is the project "Bio-TUNE" about.

levels    unmet    cells    tissue    preventing    antibacterial    subsequent    medicine    implants    devoted    surfaces    explore    inhibit    host    biointegration    biomimetic    generation    introduces    hence    simultaneously    biomolecular    innovative    ideally    accepted    active    decipher    physiological    cytotoxic    biochemical    science    interaction    generate    patient    effect    biofilm    positively    multifunctional    biomaterials    topographically    topographical    bio    materials    bacteria    medical    personalized    life    technological    paradigms    regeneration    seek    competition    treatments    selective    combined    representing    frequently    infection    cell    tune    agents    clinical    patterns    favor    adhesion    surrounding    eukaryotic    bacterial    mindset    quality    either    implant    catastrophic    reduce    colonization    biophysical    tend    healthcare    majority    efforts    transfer    biomaterial    coatings    instructive    significantly    mitigate    functions    tissues    ambitions    compromising    mechanistic    understand    rarely   

Project "Bio-TUNE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT POLITECNICA DE CATALUNYA 

Organization address
address: CALLE JORDI GIRONA 31
city: BARCELONA
postcode: 8034
website: www.upc.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 814˙200 €
 EC max contribution 814˙200 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT POLITECNICA DE CATALUNYA ES (BARCELONA) coordinator 216˙200.00
2    UNIVERSITA DEGLI STUDI DI CAMERINO IT (CAMERINO) participant 211˙600.00
3    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 110˙400.00
4    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 110˙400.00
5    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 87˙400.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 78˙200.00
7    GADJAH MADA UNIVERSITY ID (YOGYAKARTA) partner 0.00
8    UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN AR (SAN MARTIN BUENOS AIRES) partner 0.00
9    UNIVERSIDAD PERUANA DE CIENCIAS APLICADAS SAC PE (LIMA) partner 0.00
10    UNIVERSITI SAINS MALAYSIA* MY (PENANG) partner 0.00

Map

 Project objective

Bio-TUNE aims to develop innovative multifunctional materials to produce a new generation of medical implants with cell instructive and antibacterial potential.

In biomaterials science, it is well accepted that implant biointegration with surrounding tissues is a major goal. However, implant surfaces that facilitate cell adhesion, may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can be catastrophic and significantly reduce patient quality of life, representing an emerging concern in healthcare.

On the other hand, research efforts devoted to inhibit bacterial colonization are frequently related to cytotoxic agents or treatments that do not positively affect host tissues. Hence, ideally, to enhance the long-term success of medical implants, biomaterial surfaces should reduce bacterial colonization levels without compromising the physiological functions of eukaryotic cells. Yet, the majority of current approaches tend to only focus on either improving cell adhesion or preventing bacterial infection but rarely explore a combined effect.

In Bio-TUNE we focus on multifunctional coatings to simultaneously address and mitigate both these problems. Thus, Bio-TUNE introduces a new mindset and different paradigms in the development of biomaterials to respond to unmet clinical needs.

Bio-TUNE ambitions to 1) Study and understand the interaction of eukaryotic cells with bacteria at the biophysical and biomolecular level; 2) To develop cell instructive and antibacterial surfaces via biochemical and topographical approaches; 3) Transfer this technology to medical implants.

We seek to decipher the mechanistic of eukaryotic and bacterial cell competition, generate new selective and multi-potential coatings and topographically-active patterns, and their technological transfer leading to a generation of advanced biomimetic materials for tissue regeneration and personalized medicine.

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The information about "BIO-TUNE" are provided by the European Opendata Portal: CORDIS opendata.

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