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Bio-TUNE SIGNED

Fine tune of cellular behavior: multifunctional materials for medical implants

Total Cost €

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EC-Contrib. €

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Partnership

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Bio-TUNE project word cloud

Explore the words cloud of the Bio-TUNE project. It provides you a very rough idea of what is the project "Bio-TUNE" about.

tune interaction combined either bacteria devoted simultaneously selective implant biointegration explore medical cell patient technological infection tissue understand seek surfaces science ideally representing physiological innovative life cells positively transfer materials levels bacterial inhibit generate catastrophic rarely biomaterial agents healthcare mitigate subsequent generation biochemical regeneration cytotoxic topographically coatings biomolecular competition compromising paradigms accepted tend unmet biomimetic antibacterial surrounding treatments personalized biofilm colonization reduce tissues decipher biomaterials favor frequently eukaryotic multifunctional patterns preventing introduces majority adhesion instructive biophysical effect significantly implants clinical quality mindset host ambitions functions mechanistic topographical medicine efforts bio active hence

Project "Bio-TUNE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT POLITECNICA DE CATALUNYA Organization address address: CALLE JORDI GIRONA 31 city: BARCELONA postcode: 8034 website: www.upc.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	814˙200 €
EC max contribution	814˙200 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2019
Funding Scheme	MSCA-RISE
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT POLITECNICA DE CATALUNYA UNIVERSITAT POLITECNICA DE CATALUNYA Organization address address: CALLE JORDI GIRONA 31 city: BARCELONA postcode: 8034 website: www.upc.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	216˙200.00
2	UNIVERSITA DEGLI STUDI DI CAMERINO UNIVERSITA DEGLI STUDI DI CAMERINO Organization address address: PIAZZA CAVOUR 19F city: CAMERINO postcode: 62032 website: www.unicam.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CAMERINO)	participant	211˙600.00
3	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	110˙400.00
4	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	110˙400.00
5	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	87˙400.00
6	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	78˙200.00
7	GADJAH MADA UNIVERSITY GADJAH MADA UNIVERSITY Organization address address: BULAKSUMUR city: YOGYAKARTA postcode: 55281 website: www.ugm.ac.id contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ID (YOGYAKARTA)	partner	0.00
8	UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN Organization address address: MARTIN DE IRIGOYEN 3100 city: SAN MARTIN BUENOS AIRES postcode: 1650 website: www.idaes.edu.ar contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (SAN MARTIN BUENOS AIRES)	partner	0.00
9	UNIVERSIDAD PERUANA DE CIENCIAS APLICADAS SAC UNIVERSIDAD PERUANA DE CIENCIAS APLICADAS SAC Organization address address: AV ALONSO DE MOLINA 1611 SANTIAGO DE SURCO city: LIMA postcode: 33 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PE (LIMA)	partner	0.00
10	UNIVERSITI SAINS MALAYSIA* UNIVERSITI SAINS MALAYSIA* Organization address address: MINDEN city: PENANG postcode: 11800 website: http://www.usm.my/my contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	MY (PENANG)	partner	0.00

Map

Project objective

Bio-TUNE aims to develop innovative multifunctional materials to produce a new generation of medical implants with cell instructive and antibacterial potential.

In biomaterials science, it is well accepted that implant biointegration with surrounding tissues is a major goal. However, implant surfaces that facilitate cell adhesion, may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can be catastrophic and significantly reduce patient quality of life, representing an emerging concern in healthcare.

On the other hand, research efforts devoted to inhibit bacterial colonization are frequently related to cytotoxic agents or treatments that do not positively affect host tissues. Hence, ideally, to enhance the long-term success of medical implants, biomaterial surfaces should reduce bacterial colonization levels without compromising the physiological functions of eukaryotic cells. Yet, the majority of current approaches tend to only focus on either improving cell adhesion or preventing bacterial infection but rarely explore a combined effect.

In Bio-TUNE we focus on multifunctional coatings to simultaneously address and mitigate both these problems. Thus, Bio-TUNE introduces a new mindset and different paradigms in the development of biomaterials to respond to unmet clinical needs.

Bio-TUNE ambitions to 1) Study and understand the interaction of eukaryotic cells with bacteria at the biophysical and biomolecular level; 2) To develop cell instructive and antibacterial surfaces via biochemical and topographical approaches; 3) Transfer this technology to medical implants.

We seek to decipher the mechanistic of eukaryotic and bacterial cell competition, generate new selective and multi-potential coatings and topographically-active patterns, and their technological transfer leading to a generation of advanced biomimetic materials for tissue regeneration and personalized medicine.

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The information about "BIO-TUNE" are provided by the European Opendata Portal: CORDIS opendata.

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