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Bio-TUNE SIGNED

Fine tune of cellular behavior: multifunctional materials for medical implants

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Bio-TUNE project word cloud

Explore the words cloud of the Bio-TUNE project. It provides you a very rough idea of what is the project "Bio-TUNE" about.

cells    tend    healthcare    patterns    unmet    subsequent    surfaces    biofilm    interaction    quality    multifunctional    effect    agents    host    tissue    mechanistic    accepted    eukaryotic    biophysical    personalized    technological    regeneration    significantly    devoted    innovative    infection    mindset    majority    bacterial    levels    compromising    positively    mitigate    patient    biomolecular    generation    seek    frequently    selective    understand    implant    introduces    colonization    reduce    combined    physiological    hence    favor    adhesion    life    decipher    biomaterials    medical    coatings    topographical    cell    active    antibacterial    biomaterial    tissues    explore    medicine    paradigms    efforts    generate    bacteria    cytotoxic    ambitions    simultaneously    clinical    preventing    materials    surrounding    biomimetic    representing    treatments    biochemical    science    catastrophic    implants    competition    biointegration    topographically    rarely    ideally    functions    tune    instructive    bio    inhibit    either    transfer   

Project "Bio-TUNE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT POLITECNICA DE CATALUNYA 

Organization address
address: CALLE JORDI GIRONA 31
city: BARCELONA
postcode: 8034
website: www.upc.edu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 814˙200 €
 EC max contribution 814˙200 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2019
 Funding Scheme MSCA-RISE
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT POLITECNICA DE CATALUNYA ES (BARCELONA) coordinator 216˙200.00
2    UNIVERSITA DEGLI STUDI DI CAMERINO IT (CAMERINO) participant 211˙600.00
3    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 110˙400.00
4    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 110˙400.00
5    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 87˙400.00
6    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 78˙200.00
7    GADJAH MADA UNIVERSITY ID (YOGYAKARTA) partner 0.00
8    UNIVERSIDAD NACIONAL DE GENERAL SAN MARTIN AR (SAN MARTIN BUENOS AIRES) partner 0.00
9    UNIVERSIDAD PERUANA DE CIENCIAS APLICADAS SAC PE (LIMA) partner 0.00
10    UNIVERSITI SAINS MALAYSIA* MY (PENANG) partner 0.00

Map

 Project objective

Bio-TUNE aims to develop innovative multifunctional materials to produce a new generation of medical implants with cell instructive and antibacterial potential.

In biomaterials science, it is well accepted that implant biointegration with surrounding tissues is a major goal. However, implant surfaces that facilitate cell adhesion, may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can be catastrophic and significantly reduce patient quality of life, representing an emerging concern in healthcare.

On the other hand, research efforts devoted to inhibit bacterial colonization are frequently related to cytotoxic agents or treatments that do not positively affect host tissues. Hence, ideally, to enhance the long-term success of medical implants, biomaterial surfaces should reduce bacterial colonization levels without compromising the physiological functions of eukaryotic cells. Yet, the majority of current approaches tend to only focus on either improving cell adhesion or preventing bacterial infection but rarely explore a combined effect.

In Bio-TUNE we focus on multifunctional coatings to simultaneously address and mitigate both these problems. Thus, Bio-TUNE introduces a new mindset and different paradigms in the development of biomaterials to respond to unmet clinical needs.

Bio-TUNE ambitions to 1) Study and understand the interaction of eukaryotic cells with bacteria at the biophysical and biomolecular level; 2) To develop cell instructive and antibacterial surfaces via biochemical and topographical approaches; 3) Transfer this technology to medical implants.

We seek to decipher the mechanistic of eukaryotic and bacterial cell competition, generate new selective and multi-potential coatings and topographically-active patterns, and their technological transfer leading to a generation of advanced biomimetic materials for tissue regeneration and personalized medicine.

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The information about "BIO-TUNE" are provided by the European Opendata Portal: CORDIS opendata.

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