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TOPOCELL SIGNED

A cell separation microfabricated platform for cell migration and invasion assays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TOPOCELL project word cloud

Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.

geometry    topography    elastomeric    erc    biology    favor    screening    substrate    boyden    profiles    cells    resolutions    spaces    matrix    differentiation    inflammation    surrounding    plane    transcell    narrow    possibilities    microfluidic    stiffness    accepted    wounds    technologies    functions    fundamental    micro    physical    cell    transmigration    nanotechnology    therapies    progression    anticipate    limited    probe    sorting    micropillar    easily    physiological    pillars    spatial    expression    transmigrate    tissue    limitations    genetic    ultimately    porosity    accurate    interactions    confinement    tumor    incorporating    versatile    tuned    migration    investigations    microfabricated    environment    designed    substrates    encounter    prevent    offers    duracell    drug    assays    spreading    composition    tissues    chambers    cellular    sized    analyze    variability    near    answer    biological    overcome    confined    therapy    environments    micron    tools    versatility    microenvironment    temporal    ordered    homeostasis    contain   

Project "TOPOCELL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 150˙000.00

Map

 Project objective

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.

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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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