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TOPOCELL SIGNED

A cell separation microfabricated platform for cell migration and invasion assays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TOPOCELL project word cloud

Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.

resolutions    wounds    limited    therapies    variability    encounter    analyze    pillars    transmigration    physical    plane    tuned    versatile    environments    matrix    accepted    cellular    ordered    stiffness    cell    ultimately    geometry    cells    duracell    composition    assays    overcome    substrate    incorporating    limitations    offers    spatial    physiological    anticipate    temporal    spaces    micro    homeostasis    designed    screening    microfabricated    inflammation    chambers    interactions    answer    therapy    narrow    contain    versatility    erc    probe    microfluidic    nanotechnology    fundamental    genetic    micron    expression    technologies    investigations    porosity    profiles    confined    surrounding    biology    progression    favor    easily    tissues    possibilities    environment    prevent    accurate    sized    topography    migration    drug    tissue    tumor    confinement    boyden    tools    microenvironment    elastomeric    transcell    functions    transmigrate    spreading    differentiation    substrates    near    micropillar    biological    sorting   

Project "TOPOCELL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 150˙000.00

Map

 Project objective

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.

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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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