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TOPOCELL SIGNED

A cell separation microfabricated platform for cell migration and invasion assays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TOPOCELL project word cloud

Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.

transmigration    tools    contain    micron    answer    incorporating    encounter    microfabricated    inflammation    favor    genetic    drug    topography    confinement    cell    tuned    porosity    accurate    micropillar    easily    limited    therapies    homeostasis    boyden    possibilities    versatility    investigations    assays    plane    composition    interactions    technologies    tissue    ordered    stiffness    migration    transcell    differentiation    chambers    expression    duracell    cells    designed    probe    tumor    substrates    transmigrate    biological    ultimately    anticipate    microfluidic    temporal    limitations    spatial    near    resolutions    sized    environment    spaces    micro    functions    analyze    fundamental    tissues    nanotechnology    profiles    narrow    prevent    biology    variability    confined    spreading    microenvironment    offers    physical    pillars    wounds    surrounding    matrix    environments    overcome    erc    physiological    screening    cellular    accepted    versatile    sorting    geometry    elastomeric    therapy    substrate    progression   

Project "TOPOCELL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 150˙000.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.

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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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