Opendata, web and dolomites
TOPOCELL SIGNED
A cell separation microfabricated platform for cell migration and invasion assays
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0TOPOCELL project word cloud
Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.
confined
biology
topography
functions
ultimately
offers
chambers
assays
limitations
therapies
tumor
micron
transmigrate
versatility
cellular
wounds
tissue
temporal
environment
ordered
nanotechnology
narrow
designed
substrates
variability
favor
composition
tuned
therapy
fundamental
possibilities
physiological
plane
resolutions
profiles
stiffness
confinement
technologies
duracell
porosity
anticipate
inflammation
microenvironment
micro
elastomeric
pillars
micropillar
spatial
analyze
matrix
screening
probe
genetic
boyden
drug
substrate
accurate
transmigration
accepted
progression
differentiation
contain
migration
homeostasis
spreading
answer
versatile
tools
limited
microfluidic
sorting
cell
tissues
biological
interactions
surrounding
sized
cells
easily
microfabricated
spaces
prevent
incorporating
physical
erc
near
environments
expression
investigations
encounter
overcome
transcell
geometry
Project "TOPOCELL" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 0 € |
| EC max contribution | 150˙000 € (0%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2019-PoC |
| Funding Scheme | ERC-POC-LS |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-06-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 150˙000.00 |
Map
Project objective
Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.
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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.
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lastchecktime (2024-07-27 1:41:00) correctly updated