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TOPOCELL SIGNED

A cell separation microfabricated platform for cell migration and invasion assays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 TOPOCELL project word cloud

Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.

anticipate    fundamental    resolutions    physiological    cell    micron    possibilities    contain    favor    environment    substrate    versatility    sorting    variability    technologies    therapies    analyze    topography    progression    spatial    tools    overcome    tissue    therapy    porosity    stiffness    functions    tuned    assays    accurate    ultimately    microfabricated    easily    designed    tumor    matrix    cells    probe    offers    boyden    interactions    temporal    incorporating    spaces    geometry    limited    substrates    genetic    near    encounter    surrounding    prevent    migration    transmigrate    duracell    confined    transcell    microfluidic    composition    investigations    drug    limitations    inflammation    transmigration    differentiation    versatile    confinement    spreading    micropillar    elastomeric    tissues    erc    cellular    expression    plane    profiles    narrow    physical    ordered    homeostasis    biology    microenvironment    biological    pillars    environments    screening    sized    accepted    chambers    answer    nanotechnology    wounds    micro   

Project "TOPOCELL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 150˙000.00

Map

 Project objective

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.

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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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