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TOPOCELL SIGNED

A cell separation microfabricated platform for cell migration and invasion assays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 TOPOCELL project word cloud

Explore the words cloud of the TOPOCELL project. It provides you a very rough idea of what is the project "TOPOCELL" about.

profiles    micro    environments    porosity    offers    narrow    cellular    wounds    differentiation    prevent    microenvironment    analyze    spaces    answer    biology    elastomeric    therapies    therapy    easily    transcell    screening    composition    micropillar    tissues    transmigration    contain    environment    micron    ultimately    sized    interactions    topography    boyden    versatility    near    confinement    functions    duracell    tools    erc    limitations    designed    investigations    resolutions    transmigrate    cell    limited    sorting    incorporating    favor    microfabricated    spatial    physiological    microfluidic    assays    technologies    confined    accepted    overcome    pillars    matrix    ordered    nanotechnology    temporal    genetic    cells    chambers    inflammation    plane    substrates    expression    probe    stiffness    fundamental    encounter    variability    spreading    accurate    versatile    progression    biological    substrate    tissue    possibilities    drug    physical    surrounding    anticipate    geometry    migration    homeostasis    tumor    tuned   

Project "TOPOCELL" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 0 €
 EC max contribution 150˙000 € (0%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-PoC
 Funding Scheme ERC-POC-LS
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 150˙000.00

Map

 Project objective

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expression profiles. We anticipate that the versatility of this method will offer new opportunities for fundamental research in cell biology, but also in cell therapies and drug screening.

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The information about "TOPOCELL" are provided by the European Opendata Portal: CORDIS opendata.

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