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JOINTPROMISE SIGNED

PRECISION MANUFACTURING OF MICROENGINEERED COMPLEX JOINT IMPLANTS

Total Cost €

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EC-Contrib. €

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Partnership

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 JOINTPROMISE project word cloud

Explore the words cloud of the JOINTPROMISE project. It provides you a very rough idea of what is the project "JOINTPROMISE" about.

execute    surface    joints    paradigm    there    feasibility    building    shift    ageing    vascularised    arthritic    containing    model    structure    osteochondral    breakthroughs    socioeconomic    gmp    implantation    robotics    microtissue    biological    clinical    rising    strive    defects    producing    25    time    hence    automated    scaled    manual    defect    blocks    disease    volume    paves    patient    prevent    humans    patterned    implant    osteoarthritis    regenerative    oa    efficacy    solution    possess    technologies    unmet    microtissues    cartilaginous    demand    regeneration    inbuilt    precise    organoid    deep    predictively    tissue    3d    engineered    jointpromise    bioprinting    adult    platform    entire    mostly    biologic    cartilage    allowed    implants    population    affordable    structures    underlying    prevalent    adopting    convincing    manufacturing    grade    articular    living    bone    cover    rate    society    regenerating    models    repair    minipig    bioreactor    animal    integration    joint   

Project "JOINTPROMISE" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 7˙901˙115 €
 EC max contribution 7˙901˙115 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙683˙000.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 1˙745˙487.00
3    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 1˙694˙275.00
4    POIETIS FR (PESSAC) participant 1˙436˙687.00
5    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 783˙750.00
6    STEMCELL TECHNOLOGIES UK LTD UK (CAMBRIDGE) participant 557˙915.00

Map

 Project objective

There is convincing evidence, in animal models and in humans, that deep osteochondral defects of the joint surface lead to a high rate of osteoarthritis (OA) over time. The disease process in OA, the most prevalent arthritic disease affecting 25% of the adult population, involves the entire joint affecting both the articular cartilage and the underlying bone. Hence it is crucial to consider the entire osteochondral unit as a target for repair. Tissue engineered implants could provide a solution for the regeneration of this type of defects and prevent the development of OA. This project aims to address this unmet clinical need by developing complex joint implants that will possess the spatially inbuilt biologic information for regenerating these challenging defects. Breakthroughs in organoid technologies have allowed the development of cartilaginous microtissue structures that can predictively execute regenerative programmes upon implantation. These microtissues can be used as building blocks for bottom-up 3D bioprinting of living joint implants. In order to be able to produce scaled-up implants containing at the same time a highly precise structure, integration of bioprinting technologies is needed. Moreover in order to cover rising clinical demand the whole manufacturing process, which is mostly manual today, will need to be automated adopting robotics, bioprinting and bioreactor technologies. In order to demonstrate implant feasibility and efficacy, large osteochondral defect repair will be studied in the minipig, a large animal model relevant to the patient. Taken together we strive to develop an automated, GMP-grade platform producing large, patterned and vascularised joint implants providing also a paradigm shift for generic automated manufacturing of organoid-based tissue implants. JOINTPROMISE paves the way for high-volume, affordable production of entire biological joints, addressing a major socioeconomic challenge of the European ageing society.

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The information about "JOINTPROMISE" are provided by the European Opendata Portal: CORDIS opendata.

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