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Claustrum function in cortical processing and putative claustral dysfunction in schizophrenia

Total Cost €


EC-Contrib. €






 CLAUSTROFUNCT project word cloud

Explore the words cloud of the CLAUSTROFUNCT project. It provides you a very rough idea of what is the project "CLAUSTROFUNCT" about.

function    hallucinations    summary    evidences    suggest    normal    cortex    search    suggesting    neocortex    link       causal    malfunction    circuits    led    reciprocally    worldwide    establishing    expressing    expressed    potent    mental    underlying    impaired    hypothesize    transient    receptor    works    functions    hallucinogenic    traits    cognitive    exact    uniquely    salvinorin    chronic    schizophrenia    genes    reports    communication    enigmatic    found    light    executive    interconnected    associative    played    incidence    regulating    altered    deficits    cla    risk    highest    behavioral    shed    mechanisms    combination    selectively    causes    symptoms    pathology    brain    patients    dysfunction    concomitantly    lesions    influence    drug    delusions    permanent    prefrontal    cortices    peculiar    structure    opioid    subcortical    nature    potentially    claustrum    expression    disease    positioned    kappa    pfc    medical    centers    mouse    unknown    levels    cortical    circuit    network   

Project "CLAUSTROFUNCT" data sheet

The following table provides information about the project.


Organization address
city: GENEVE
postcode: 1211

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 5˙000˙000 €
 EC max contribution 5˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2026-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 5˙000˙000.00


 Project objective

Schizophrenia is a chronic mental disease having an incidence of 1% worldwide. Its symptoms are numerous and range from hallucinations to altered executive functions. Although the exact causes of schizophrenia are unknown, several works suggest that impaired communication between higher cortical centers may be important for the expression of the disease. Establishing a causal link between circuit function (and/or dysfunction) and particular behavioral traits relevant to schizophrenia may shed new light on the mechanisms underlying the pathology. Dysfunction of the prefrontal cortex (PFC) may contribute to cognitive deficits relevant to schizophrenia. In a search for circuits potentially regulating the PFC, we identified an enigmatic and not well-studied network, the claustrum (CLA). This subcortical structure of unknown function is supposed to be highly reciprocally interconnected with the neocortex, especially associative cortices involved in behavioral traits relevant to schizophrenia. It is thus uniquely positioned to influence cortical communication. The CLA is also peculiar because it represents the brain structure expressing the highest levels of kappa opioid receptor, the receptor of the most potent hallucinogenic drug found in nature, salvinorin A, suggesting a potential role played by the CLA in hallucinations. This link is further supported by medical reports in which patients having transient or permanent lesions in the claustrum develop hallucinations and delusions concomitantly. Finally, many risk factors genes associated to schizophrenia are strongly and often selectively expressed in the mouse claustrum. In summary, this combination of evidences led us to hypothesize that the claustrum may represent a circuit whose malfunction is relevant to the expression of schizophrenia. Our proposal will test the role of the claustrum in the normal brain and test whether its dysfunction may contribute to schizophrenia symptoms.

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The information about "CLAUSTROFUNCT" are provided by the European Opendata Portal: CORDIS opendata.

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