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CLAUSTROFUNCT SIGNED

Claustrum function in cortical processing and putative claustral dysfunction in schizophrenia

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CLAUSTROFUNCT project word cloud

Explore the words cloud of the CLAUSTROFUNCT project. It provides you a very rough idea of what is the project "CLAUSTROFUNCT" about.

   suggesting    uniquely    works    circuit    dysfunction    delusions    salvinorin    nature    unknown    disease    mental    prefrontal    circuits    potent    centers    establishing    cortical    peculiar    opioid    schizophrenia    altered    incidence    influence    led    brain    found    cortex    reciprocally    behavioral    expressing    symptoms    hallucinogenic    functions    worldwide    drug    receptor    link    suggest    causes    causal    patients    pathology    function    levels    underlying    light    lesions    executive    associative    communication    impaired    kappa    hypothesize    reports    shed    claustrum    evidences    neocortex    mechanisms    subcortical    concomitantly    cla    malfunction    positioned    combination    chronic    exact    traits    pfc    search    normal    enigmatic    risk    regulating    medical    summary    permanent    played    structure    selectively    network    cognitive    genes    expressed    transient    hallucinations    deficits    highest    interconnected    mouse    expression    cortices    potentially   

Project "CLAUSTROFUNCT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE GENEVE 

Organization address
address: RUE DU GENERAL DUFOUR 24
city: GENEVE
postcode: 1211
website: www.unige.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 5˙000˙000 €
 EC max contribution 5˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2026-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 5˙000˙000.00

Map

 Project objective

Schizophrenia is a chronic mental disease having an incidence of 1% worldwide. Its symptoms are numerous and range from hallucinations to altered executive functions. Although the exact causes of schizophrenia are unknown, several works suggest that impaired communication between higher cortical centers may be important for the expression of the disease. Establishing a causal link between circuit function (and/or dysfunction) and particular behavioral traits relevant to schizophrenia may shed new light on the mechanisms underlying the pathology. Dysfunction of the prefrontal cortex (PFC) may contribute to cognitive deficits relevant to schizophrenia. In a search for circuits potentially regulating the PFC, we identified an enigmatic and not well-studied network, the claustrum (CLA). This subcortical structure of unknown function is supposed to be highly reciprocally interconnected with the neocortex, especially associative cortices involved in behavioral traits relevant to schizophrenia. It is thus uniquely positioned to influence cortical communication. The CLA is also peculiar because it represents the brain structure expressing the highest levels of kappa opioid receptor, the receptor of the most potent hallucinogenic drug found in nature, salvinorin A, suggesting a potential role played by the CLA in hallucinations. This link is further supported by medical reports in which patients having transient or permanent lesions in the claustrum develop hallucinations and delusions concomitantly. Finally, many risk factors genes associated to schizophrenia are strongly and often selectively expressed in the mouse claustrum. In summary, this combination of evidences led us to hypothesize that the claustrum may represent a circuit whose malfunction is relevant to the expression of schizophrenia. Our proposal will test the role of the claustrum in the normal brain and test whether its dysfunction may contribute to schizophrenia symptoms.

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The information about "CLAUSTROFUNCT" are provided by the European Opendata Portal: CORDIS opendata.

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