Opendata, web and dolomites

nbPTMs SIGNED

A multifaceted platform for exploring nucleotide-based post-translational modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 nbPTMs project word cloud

Explore the words cloud of the nbPTMs project. It provides you a very rough idea of what is the project "nbPTMs" about.

play    spectrometry    health    overarching    biomedical    datasets    signalling    synthesis    publicly    made    post    disease    starting    base    nbptm    first    unbiased    translational    investigations    points    methodology    biology    proteomic    nbptms    explore    roles    forms    mapping    antibodies    community    lability    types    lies    site    pan    generate    materials    structures    sites    proteins    peptide    intensely    pathogenesis    disseminate    substrates    peptides    unveil    modified    biotechnology    scientific    chemoenzymatic    poised    innovation    discoveries    mass    conceptual    discovery    eukaryotic    exploited    nucleobase    constrained    shared    decades    interdisciplinary    fundamental    chemical    advantage    moieties    biological    cancer    territories    modifications    antigens    multiple    nucleotide    tools    converting    versatile    strategy    diseases    proteomes    scope    interface    chemically    bacterial    enrichment    characterization    protein    purpose    turning    treatment    unknown   

Project "nbPTMs" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-04-01   to  2026-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙000˙000.00

Map

 Project objective

Nucleotide-based post-translational modifications (nbPTMs) play key roles in health and disease, from bacterial pathogenesis to cancer. However, technical challenges of these versatile, but chemically complex protein modifications have constrained our fundamental understanding of even the most intensely studied nbPTMs for decades. The overarching aim of this proposal is to establish, apply and disseminate a methodology to unveil novel types of nbPTMs and allow site-specific proteomic analyses. The conceptual innovation lies in a strategy for turning the complex chemical structures of nbPTMs from a challenge to an advantage. First, shared chemical moieties will be exploited to develop pan-specific enrichment of multiple nbPTMs. For this purpose, we will generate the first nbPTMs-specific antibodies by converting specific signalling proteins into biotechnology tools for chemoenzymatic synthesis of challenging peptide antigens (aim 1). Second, we will take advantage of the chemical lability of nbPTMs to analyse modified peptides using a nucleobase-targeted mass spectrometry approach (aim 2). The unbiased scope of our methodology will make possible the discovery of as yet unknown forms of nbPTMs (aim 3) and nbPTM site mapping throughout eukaryotic proteomes (aim 4). These new materials, methods, discoveries and datasets will be made publicly available to allow future investigations of nbPTMs by the scientific community. The new substrates, sites and nbPTMs will provide starting points for biological characterization (aim 5). Poised at the interface of biology and technology, this interdisciplinary research project has the potential to explore new territories within established biomedical fields and to contribute to the knowledge base for improved treatment of diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NBPTMS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NBPTMS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CITISENSE (2019)

Evolving communication systems in response to altered sensory environments

Read More  

CAPTURE (2019)

CApturing Paradata for documenTing data creation and Use for the REsearch of the future

Read More  

CARBOFLOW (2020)

Streamlined carbon dioxide conversion in ionic liquids – a platform strategy for modern carbonylation chemistry

Read More