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nbPTMs SIGNED

A multifaceted platform for exploring nucleotide-based post-translational modifications

Total Cost €

0

EC-Contrib. €

0

Partnership

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 nbPTMs project word cloud

Explore the words cloud of the nbPTMs project. It provides you a very rough idea of what is the project "nbPTMs" about.

proteomic    advantage    disseminate    health    peptide    biology    post    nucleotide    characterization    mass    investigations    conceptual    protein    generate    decades    materials    bacterial    scope    enrichment    moieties    site    chemical    chemically    datasets    community    peptides    biotechnology    starting    nucleobase    treatment    lies    turning    intensely    multiple    points    biomedical    chemoenzymatic    strategy    scientific    tools    antibodies    nbptm    diseases    mapping    first    antigens    play    made    pathogenesis    signalling    substrates    modified    nbptms    interdisciplinary    discoveries    proteins    overarching    territories    constrained    types    interface    unveil    versatile    cancer    fundamental    eukaryotic    unbiased    exploited    shared    base    converting    sites    discovery    translational    structures    spectrometry    methodology    lability    innovation    roles    purpose    pan    poised    explore    biological    modifications    proteomes    unknown    synthesis    forms    publicly    disease   

Project "nbPTMs" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-04-01   to  2026-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 2˙000˙000.00

Map

 Project objective

Nucleotide-based post-translational modifications (nbPTMs) play key roles in health and disease, from bacterial pathogenesis to cancer. However, technical challenges of these versatile, but chemically complex protein modifications have constrained our fundamental understanding of even the most intensely studied nbPTMs for decades. The overarching aim of this proposal is to establish, apply and disseminate a methodology to unveil novel types of nbPTMs and allow site-specific proteomic analyses. The conceptual innovation lies in a strategy for turning the complex chemical structures of nbPTMs from a challenge to an advantage. First, shared chemical moieties will be exploited to develop pan-specific enrichment of multiple nbPTMs. For this purpose, we will generate the first nbPTMs-specific antibodies by converting specific signalling proteins into biotechnology tools for chemoenzymatic synthesis of challenging peptide antigens (aim 1). Second, we will take advantage of the chemical lability of nbPTMs to analyse modified peptides using a nucleobase-targeted mass spectrometry approach (aim 2). The unbiased scope of our methodology will make possible the discovery of as yet unknown forms of nbPTMs (aim 3) and nbPTM site mapping throughout eukaryotic proteomes (aim 4). These new materials, methods, discoveries and datasets will be made publicly available to allow future investigations of nbPTMs by the scientific community. The new substrates, sites and nbPTMs will provide starting points for biological characterization (aim 5). Poised at the interface of biology and technology, this interdisciplinary research project has the potential to explore new territories within established biomedical fields and to contribute to the knowledge base for improved treatment of diseases.

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The information about "NBPTMS" are provided by the European Opendata Portal: CORDIS opendata.

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