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ICE_PACK SIGNED

Polymer Materials for Cryogenic Storage and Distribution of Biologics

Total Cost €

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EC-Contrib. €

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Partnership

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 ICE_PACK project word cloud

Explore the words cloud of the ICE_PACK project. It provides you a very rough idea of what is the project "ICE_PACK" about.

medicines    functional    therapies    drugs    suitable    polymeric    proteins    disease    denaturation    molecular    batch    stabilising    selling    outcomes    pack    erc    cryopreserved    promise    recovery    diseases    cryopreserve    ice    small    supra    macromolecular    plasticizers    cold    format    situation    unprecedented    linking    oncology    ago    breaking    fundamental    scientific    nucleation    organic    stresses    bags    remove    curable    nature    biologic    toxic    accelerated    emerge    inspired    safer    requiring    molecules    ground    healthcare    21st    dramatically    transform    century    environmental    incurable    cryoprotectants    membranes    cell    benefits    imposed    post    delivering    whereby    biology    variabilities    full    inducing    pharmaceutical    biologics    cheaper    leach    cryopreservation    thaw    synthesize    stabilize    strategies    parallel    modulators    stress    75    tolerance    2017    macro    transport    chain    infectious    technologies    cancer    ten    function    therapeutics    biomaterials    changed    biochemical    solvents    protecting    structure    patient    transformation   

Project "ICE_PACK" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙863 €
 EC max contribution 1˙999˙863 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 1˙999˙863.00

Map

 Project objective

Ten years ago small molecules were the drugs of choice for most diseases. This situation has dramatically changed such that in 2017, 4 in 5 of the best-selling drugs were proteins, delivering major healthcare benefits from cancer to infectious disease. Cell-based therapies are also emerging, with the promise of making the incurable, curable (especially in oncology). However, the use of these ‘biologics’ has accelerated beyond the currently available technologies to stabilize these therapeutics against the environmental stresses imposed by the pharmaceutical cold chain. 75 % of current biologics must be cryopreserved to ensure they reach the patient in a functional format, requiring the addition of cryoprotectants (organic solvents) which are toxic, do not enable full post-thaw recovery, are complex to remove, do not stabilize cell membranes efficiently, lead to batch-to-batch post-thaw variabilities in function and cause toxic plasticizers to leach from transport bags.

ICE_PACK will develop unprecedented macro-and supra-molecular biomaterials to transform the biologic cold chain with long term impact by making these therapies more effective, cheaper, safer and more widely available.

We will synthesize polymeric cryoprotectants, inspired by Nature’s macromolecular ice modulators, capable of inducing ice nucleation, stabilising cell membranes and protecting proteins from denaturation, and apply these to cryopreserve real therapeutics. An integrated approach will be taken whereby ice nucleation and growth control will be studied in parallel to investigating the biochemical and molecular biology impact of cold stresses. Major fundamental scientific advances will also emerge, linking macromolecular structure to ice nucleation and to biochemical pathways of cold tolerance and stress. The long term outcomes of this ground breaking ERC project will be the transformation of cryopreservation strategies, suitable for 21st Century biologic medicines.

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The information about "ICE_PACK" are provided by the European Opendata Portal: CORDIS opendata.

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