Opendata, web and dolomites

ICE_PACK SIGNED

Polymer Materials for Cryogenic Storage and Distribution of Biologics

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ICE_PACK project word cloud

Explore the words cloud of the ICE_PACK project. It provides you a very rough idea of what is the project "ICE_PACK" about.

inducing    cryopreserve    post    scientific    cheaper    drugs    erc    stabilize    whereby    requiring    situation    cold    ice    pharmaceutical    fundamental    technologies    medicines    biomaterials    transform    ago    breaking    therapies    pack    century    polymeric    thaw    recovery    biochemical    proteins    benefits    stress    biologics    therapeutics    cryoprotectants    supra    molecular    solvents    emerge    curable    delivering    unprecedented    macromolecular    changed    accelerated    nature    environmental    chain    disease    safer    protecting    ground    cryopreservation    plasticizers    stabilising    incurable    bags    nucleation    2017    biology    toxic    full    biologic    synthesize    stresses    organic    parallel    diseases    inspired    tolerance    cell    cryopreserved    molecules    imposed    modulators    healthcare    75    format    strategies    linking    macro    denaturation    infectious    variabilities    patient    structure    21st    functional    batch    ten    leach    small    transport    promise    function    transformation    cancer    outcomes    dramatically    selling    membranes    remove    suitable    oncology   

Project "ICE_PACK" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙999˙863 €
 EC max contribution 1˙999˙863 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 1˙999˙863.00

Map

 Project objective

Ten years ago small molecules were the drugs of choice for most diseases. This situation has dramatically changed such that in 2017, 4 in 5 of the best-selling drugs were proteins, delivering major healthcare benefits from cancer to infectious disease. Cell-based therapies are also emerging, with the promise of making the incurable, curable (especially in oncology). However, the use of these ‘biologics’ has accelerated beyond the currently available technologies to stabilize these therapeutics against the environmental stresses imposed by the pharmaceutical cold chain. 75 % of current biologics must be cryopreserved to ensure they reach the patient in a functional format, requiring the addition of cryoprotectants (organic solvents) which are toxic, do not enable full post-thaw recovery, are complex to remove, do not stabilize cell membranes efficiently, lead to batch-to-batch post-thaw variabilities in function and cause toxic plasticizers to leach from transport bags.

ICE_PACK will develop unprecedented macro-and supra-molecular biomaterials to transform the biologic cold chain with long term impact by making these therapies more effective, cheaper, safer and more widely available.

We will synthesize polymeric cryoprotectants, inspired by Nature’s macromolecular ice modulators, capable of inducing ice nucleation, stabilising cell membranes and protecting proteins from denaturation, and apply these to cryopreserve real therapeutics. An integrated approach will be taken whereby ice nucleation and growth control will be studied in parallel to investigating the biochemical and molecular biology impact of cold stresses. Major fundamental scientific advances will also emerge, linking macromolecular structure to ice nucleation and to biochemical pathways of cold tolerance and stress. The long term outcomes of this ground breaking ERC project will be the transformation of cryopreservation strategies, suitable for 21st Century biologic medicines.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ICE_PACK" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ICE_PACK" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Regen-membrane (2019)

Pulsed Electrophoretic Deposition to give Membranes for Regenerative Medicine

Read More  

CoaExMatter (2020)

Bio-inspired Coacervate Extruded Materials

Read More  

H I C I (2020)

Transcriptional and epigenetic control of tissue regenerative HB-EGF in autoimmune CNS inflammation

Read More