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TrojanDC SIGNED

Harnessing dendritic cell reprogramming for cancer immunotherapy

Total Cost €

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EC-Contrib. €

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Partnership

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 TrojanDC project word cloud

Explore the words cloud of the TrojanDC project. It provides you a very rough idea of what is the project "TrojanDC" about.

apc    tumors    mouse    motion    endogenous    heterogeneity    immune    time    evasion    characterization    mount    combination    apcs    vivo    group    infiltration    elicits    immunotherapy    intratumoral    dc    transcriptome    strategy    screen    cells    dcs    hypothesize    human    innovative    antigens    employing    tas    hypothesis    chromatin    endowed    surface    models    recruitment    cues    antigen    therapy    downregulation    genetic    cell    hallmark    offers    first    paving    reprogrammed    therapeutic    fibroblasts    induction    reprogramming    reprograms    generation    presentation    followed    single    inhibition    dendritic    surveillance    an    evade    entirely    pioneering    avenues    peptidome    attack    transcription    tumor    identity    regression    tfs    gene    contribution    direct    constellation    combinations    external    sufficient    accessibility    optimal    combine    overcome    reprogram    accumulation    presenting    tf    mutations    cancer    function   

Project "TrojanDC" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙999˙835 €
 EC max contribution 1˙999˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙999˙835.00

Map

 Project objective

An important hallmark of cancer is the ability to evade the immune system. Genetic mutations in tumor cells result in the accumulation of tumor antigens (TAs), however, increased cell heterogeneity, downregulation of antigen presentation or inhibition of immune cell infiltration allows immune surveillance evasion. For the first time, direct cell reprogramming offers exciting opportunities to overcome these challenges. My group has recently identified a combination of transcription factors (TFs) sufficient to reprogram mouse fibroblasts into antigen-presenting dendritic cells (DCs), providing a new strategy to set in motion antigen-specific immune responses. I hypothesize that a similar combination reprograms tumor cells into antigen presenting cells (APCs). This proposal aims to test a cancer immunotherapy concept based on DC reprogramming and endowed APC function in tumor cells. The work will proceed in three steps. First, I will define optimal TF combinations and external cues to efficiently reprogram human fibroblasts into DCs employing an innovative single-cell screen. Then, I will reprogram mouse and human tumor cells into tumor-APCs followed by characterization of transcriptome, chromatin accessibility, surface peptidome and ability to present antigens to T cells. Finally, I will test whether reprogrammed cells mount an attack against tumors in mouse models. I will further test the hypothesis that intratumoral delivery of reprogramming factors elicits in vivo antigen presentation, immune cell recruitment and tumor regression. The approach proposed here will combine DCs’ antigen processing and presenting abilities with the endogenous generation of TAs. The induction of DC identity in cancer cells with ability to present a constellation of TAs will open new research and therapeutic avenues. This project represents a pioneering contribution by merging cell reprogramming and cancer immunotherapy, paving the way for an entirely new approach to cancer gene therapy.

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The information about "TROJANDC" are provided by the European Opendata Portal: CORDIS opendata.

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