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TrojanDC SIGNED

Harnessing dendritic cell reprogramming for cancer immunotherapy

Total Cost €

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EC-Contrib. €

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Partnership

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 TrojanDC project word cloud

Explore the words cloud of the TrojanDC project. It provides you a very rough idea of what is the project "TrojanDC" about.

contribution    attack    avenues    hallmark    immunotherapy    paving    pioneering    optimal    transcription    evasion    cell    tfs    antigen    followed    screen    combinations    accessibility    surface    reprogramming    chromatin    reprogram    human    mouse    immune    therapy    elicits    heterogeneity    infiltration    fibroblasts    endowed    innovative    motion    an    entirely    apcs    dendritic    overcome    group    presenting    offers    recruitment    inhibition    evade    generation    time    characterization    dc    cells    tumor    vivo    accumulation    tumors    genetic    gene    hypothesize    sufficient    constellation    cancer    surveillance    regression    combination    reprograms    presentation    peptidome    transcriptome    endogenous    tf    mutations    external    cues    mount    single    downregulation    first    direct    strategy    reprogrammed    dcs    antigens    models    hypothesis    combine    employing    tas    intratumoral    function    induction    therapeutic    identity    apc   

Project "TrojanDC" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙999˙835 €
 EC max contribution 1˙999˙835 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2020
 Duration (year-month-day) from 2020-06-01   to  2025-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙999˙835.00

Map

 Project objective

An important hallmark of cancer is the ability to evade the immune system. Genetic mutations in tumor cells result in the accumulation of tumor antigens (TAs), however, increased cell heterogeneity, downregulation of antigen presentation or inhibition of immune cell infiltration allows immune surveillance evasion. For the first time, direct cell reprogramming offers exciting opportunities to overcome these challenges. My group has recently identified a combination of transcription factors (TFs) sufficient to reprogram mouse fibroblasts into antigen-presenting dendritic cells (DCs), providing a new strategy to set in motion antigen-specific immune responses. I hypothesize that a similar combination reprograms tumor cells into antigen presenting cells (APCs). This proposal aims to test a cancer immunotherapy concept based on DC reprogramming and endowed APC function in tumor cells. The work will proceed in three steps. First, I will define optimal TF combinations and external cues to efficiently reprogram human fibroblasts into DCs employing an innovative single-cell screen. Then, I will reprogram mouse and human tumor cells into tumor-APCs followed by characterization of transcriptome, chromatin accessibility, surface peptidome and ability to present antigens to T cells. Finally, I will test whether reprogrammed cells mount an attack against tumors in mouse models. I will further test the hypothesis that intratumoral delivery of reprogramming factors elicits in vivo antigen presentation, immune cell recruitment and tumor regression. The approach proposed here will combine DCs’ antigen processing and presenting abilities with the endogenous generation of TAs. The induction of DC identity in cancer cells with ability to present a constellation of TAs will open new research and therapeutic avenues. This project represents a pioneering contribution by merging cell reprogramming and cancer immunotherapy, paving the way for an entirely new approach to cancer gene therapy.

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The information about "TROJANDC" are provided by the European Opendata Portal: CORDIS opendata.

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