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MicroMISTRANS SIGNED

Error-prone protein synthesis in fungal pathogens Microsporidia: its scope and potential therapeutic targeting

Total Cost €

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EC-Contrib. €

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Partnership

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 MicroMISTRANS project word cloud

Explore the words cloud of the MicroMISTRANS project. It provides you a very rough idea of what is the project "MicroMISTRANS" about.

fish    experimental    treatable    obligate    handful    health    protein    proteomic    appropriate    translation    manipulating    evade    grow    complement    tools    multidisciplinary    investigation    biochemistry    pathogen    manipulate    synthesis    transferable    renowned    world    synergistically    human    young    university    immune    inaccurate    host    unexplored    expertise    despite    intracellular    evolution    isoforms    implications    valuable    outcome    eukaryotic    career    infected    proteomes    toxicity    center    mammalian    independent    ubiquitous    rare    laboratories    proteomics    move    background    cultures    asset    lines    excellent    cell    laboratory    drugs    microsporidia    researcher    newcastle    genes    cattle    prone    genetic    poorly    transition    biology    completing    cultivating    modulate    equip    threaten    combining    uk    lack    diversify    scientist    molecular    organisms    totally    myriad    first    skill    error    interactions    pathogens    training    insights    insects    industrmicrosporidia    microbiology    industrially    mistranslation   

Project "MicroMISTRANS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 224˙933.00

Map

 Project objective

Microsporidia are ubiquitous and poorly treatable eukaryotic obligate intracellular pathogens that threaten human health and industrMicrosporidia are poorly treatable eukaryotic pathogens that threaten human health and industrially valuable insects, fish, and cattle. Despite Microsporidia being recognized as emerging pathogens that require development of new drugs, many aspects of their biology remain totally unexplored due to a lack of appropriate genetic tools and because only a handful of laboratories in the world can grow and manipulate Microsporidia in infected host organisms or cell cultures. This proposal involves a promising scientist with a background in biochemistry and molecular biology and who will move to a host laboratory in Newcastle University, UK – a renowned center for excellent training of young researchers, and a leading research center in the field of pathogen evolution. The researcher will undertake a multidisciplinary investigation, combining microbiology, proteomics, and molecular biology, in order to investigate how Microsporidia diversify their proteomes through error-prone protein synthesis (mistranslation). The researcher’s training at the host laboratory – in cultivating and manipulating Microsporidia in mammalian cell lines for proteomic and toxicity studies – will synergistically complement the researcher’s expertise in molecular biology of protein synthesis. Completing the project will equip the researcher with a rare, increasingly valuable and transferable skill of Microsporidia experimental biology that will be a key asset in his transition to an independent research career. The project will deliver the first detailed insights into the ability of Microsporidia to produce myriad protein isoforms from their genes as a result of highly inaccurate translation. The outcome of this project will have general implications for understanding how eukaryotic pathogens can modulate their interactions with the host and evade host immune systems.

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The information about "MICROMISTRANS" are provided by the European Opendata Portal: CORDIS opendata.

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