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MicroMISTRANS SIGNED

Error-prone protein synthesis in fungal pathogens Microsporidia: its scope and potential therapeutic targeting

Total Cost €

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EC-Contrib. €

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Partnership

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 MicroMISTRANS project word cloud

Explore the words cloud of the MicroMISTRANS project. It provides you a very rough idea of what is the project "MicroMISTRANS" about.

expertise    evade    outcome    center    experimental    evolution    threaten    skill    genes    grow    implications    poorly    rare    mistranslation    inaccurate    first    biology    appropriate    newcastle    fish    toxicity    handful    interactions    excellent    insights    industrmicrosporidia    mammalian    isoforms    insects    laboratory    translation    host    cell    health    background    synergistically    career    infected    diversify    lines    error    researcher    proteomic    lack    prone    obligate    microsporidia    world    myriad    transferable    intracellular    university    completing    treatable    move    cultivating    training    genetic    eukaryotic    scientist    pathogen    cultures    despite    transition    combining    industrially    protein    biochemistry    immune    pathogens    totally    laboratories    renowned    proteomics    manipulating    uk    molecular    complement    unexplored    tools    proteomes    multidisciplinary    organisms    synthesis    asset    ubiquitous    investigation    cattle    human    microbiology    equip    modulate    independent    manipulate    drugs    valuable    young   

Project "MicroMISTRANS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 224˙933.00

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 Project objective

Microsporidia are ubiquitous and poorly treatable eukaryotic obligate intracellular pathogens that threaten human health and industrMicrosporidia are poorly treatable eukaryotic pathogens that threaten human health and industrially valuable insects, fish, and cattle. Despite Microsporidia being recognized as emerging pathogens that require development of new drugs, many aspects of their biology remain totally unexplored due to a lack of appropriate genetic tools and because only a handful of laboratories in the world can grow and manipulate Microsporidia in infected host organisms or cell cultures. This proposal involves a promising scientist with a background in biochemistry and molecular biology and who will move to a host laboratory in Newcastle University, UK – a renowned center for excellent training of young researchers, and a leading research center in the field of pathogen evolution. The researcher will undertake a multidisciplinary investigation, combining microbiology, proteomics, and molecular biology, in order to investigate how Microsporidia diversify their proteomes through error-prone protein synthesis (mistranslation). The researcher’s training at the host laboratory – in cultivating and manipulating Microsporidia in mammalian cell lines for proteomic and toxicity studies – will synergistically complement the researcher’s expertise in molecular biology of protein synthesis. Completing the project will equip the researcher with a rare, increasingly valuable and transferable skill of Microsporidia experimental biology that will be a key asset in his transition to an independent research career. The project will deliver the first detailed insights into the ability of Microsporidia to produce myriad protein isoforms from their genes as a result of highly inaccurate translation. The outcome of this project will have general implications for understanding how eukaryotic pathogens can modulate their interactions with the host and evade host immune systems.

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The information about "MICROMISTRANS" are provided by the European Opendata Portal: CORDIS opendata.

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