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MicroMISTRANS SIGNED

Error-prone protein synthesis in fungal pathogens Microsporidia: its scope and potential therapeutic targeting

Total Cost €

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EC-Contrib. €

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Partnership

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 MicroMISTRANS project word cloud

Explore the words cloud of the MicroMISTRANS project. It provides you a very rough idea of what is the project "MicroMISTRANS" about.

eukaryotic    immune    drugs    threaten    manipulating    asset    tools    move    laboratory    health    transition    manipulate    uk    combining    cattle    insights    pathogens    first    handful    genes    human    world    ubiquitous    evade    evolution    outcome    independent    lines    modulate    obligate    insects    unexplored    molecular    scientist    microbiology    laboratories    industrmicrosporidia    prone    poorly    center    intracellular    appropriate    protein    diversify    treatable    error    cultivating    translation    organisms    multidisciplinary    cell    equip    myriad    grow    completing    transferable    genetic    industrially    researcher    toxicity    fish    synergistically    proteomic    cultures    biology    pathogen    newcastle    synthesis    implications    microsporidia    excellent    renowned    expertise    investigation    lack    skill    proteomics    infected    biochemistry    mammalian    despite    valuable    university    interactions    rare    mistranslation    training    inaccurate    isoforms    background    experimental    totally    complement    proteomes    career    host    young   

Project "MicroMISTRANS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 224˙933.00

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 Project objective

Microsporidia are ubiquitous and poorly treatable eukaryotic obligate intracellular pathogens that threaten human health and industrMicrosporidia are poorly treatable eukaryotic pathogens that threaten human health and industrially valuable insects, fish, and cattle. Despite Microsporidia being recognized as emerging pathogens that require development of new drugs, many aspects of their biology remain totally unexplored due to a lack of appropriate genetic tools and because only a handful of laboratories in the world can grow and manipulate Microsporidia in infected host organisms or cell cultures. This proposal involves a promising scientist with a background in biochemistry and molecular biology and who will move to a host laboratory in Newcastle University, UK – a renowned center for excellent training of young researchers, and a leading research center in the field of pathogen evolution. The researcher will undertake a multidisciplinary investigation, combining microbiology, proteomics, and molecular biology, in order to investigate how Microsporidia diversify their proteomes through error-prone protein synthesis (mistranslation). The researcher’s training at the host laboratory – in cultivating and manipulating Microsporidia in mammalian cell lines for proteomic and toxicity studies – will synergistically complement the researcher’s expertise in molecular biology of protein synthesis. Completing the project will equip the researcher with a rare, increasingly valuable and transferable skill of Microsporidia experimental biology that will be a key asset in his transition to an independent research career. The project will deliver the first detailed insights into the ability of Microsporidia to produce myriad protein isoforms from their genes as a result of highly inaccurate translation. The outcome of this project will have general implications for understanding how eukaryotic pathogens can modulate their interactions with the host and evade host immune systems.

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The information about "MICROMISTRANS" are provided by the European Opendata Portal: CORDIS opendata.

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