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Molecular Device for Optical Monitoring of Self-Replication in Compartments

Total Cost €


EC-Contrib. €






Project "SRCV" data sheet

The following table provides information about the project.


Organization address
address: Broerstraat 5
postcode: 9712CP

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Unravelling the origin of life and achieving the de-novo synthesis of life are among the grand challenges in contemporary science. Self-replicating molecules play a central role in addressing these challenges. Progress in the field of self-replication is hampered by limitations in monitoring the replication process in real-time, particularly when using low concentrations and small sample volumes (i.e. in protocell environments). Here we propose to employ, for the first time, a new optical pattern-generating combinatorial fluorescent molecular device (expertise of the Experienced Researcher) for the real-time monitoring of the dynamic evolution of self-replicating molecules (expertise of the Host Lab). The binding of the sensor to the self-replicators affects the intensity and/or position of the bands of each of the chromophores contained in the sensor at different emission channels, thus generating a unique optical fingerprint (fluorescent pattern) for each self-replicator. The method allows optical identification and tracking of self-replicators in real-time and requires only small sample volumes. The latter characteristic allows self-replication to be monitored inside cell-like compartments (coascervate droplet or bilayer vesicles), enabling, for the first time, to study replication inside such compartments. Merging replication with compartmentalization constitute an important towards developing a minimal form of life. Furthermore, compartmentalization in small volumes allows large numbers of experiments to be conducted in parallel, which would, for the first time, enable studying stochastic effects important for evolution of synthetic self-replicators.

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The information about "SRCV" are provided by the European Opendata Portal: CORDIS opendata.

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