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OMIT SIGNED

The role of microbial Oxylipins in the MIcrobe-hosT dialogue

Total Cost €

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EC-Contrib. €

0

Partnership

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 OMIT project word cloud

Explore the words cloud of the OMIT project. It provides you a very rough idea of what is the project "OMIT" about.

signalling    ms    training    microbiome    profiling    appreciated    migration    cell    platform    add    function    expression    humans    gene    leadership    career    competencies    perceived    latter    omit    characterised    fellowships    faecal    oxylipins    dialogue    professional    significantly    health    co    microbially    culture    crohns    line    samples    liquid    moxy    performed    examine    healthy    patients    immune    comprising    spectrometry    fatty    platforms    supernatants    performance    vitro    oxylipin    implicit    maturity    quality    eicosanoids    biobanked    uk    society    headquarters    reactions    mass    continue    precursor    roles    proliferation    contribution    microbe    economy    receive    analysed    gained    ultra    additional    oxlipin    assays    diversity    disease    inflammation    she    regulators    discovery    secondment    incubation    scientific    host    man    microbial    functions    chromatography    experiments    biofilm    chemical    bacteria    interactions    msca    human    chemotaxis    docosanoids    signals    octadecanoids    building    hoxy    volunteers    liberated    validated    acids    oxidation    bacterial    mechanistic    independent    waters    biochemical    contributions   

Project "OMIT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-11-09   to  2022-11-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 196˙590.00

Map

 Project objective

OMIT aims to examine the role of microbial Oxylipins in the MIcrobiome:hosT dialogue. Oxylipins liberated from the oxidation of fatty acids are appreciated as key chemical signals perceived by both microbe and man. Human oxylipins (hOXY), comprising eicosanoids, docosanoids and octadecanoids are well characterised; they are implicit in many biochemical and signalling pathways in humans, including cell migration, proliferation, chemotaxis, immune reactions and most importantly, they are key regulators of inflammation. However, the diversity, functions, impact and mechanistic roles of microbially derived oxylipins (mOXY) are not well understood. State-of-the-art ultra-performance liquid chromatography-mass spectrometry (MS) platforms (secondment at Waters MS Headquarters, UK) will be developed and validated for oxylipin analysis in faecal samples and bacterial supernatants derived from co-incubation experiments (i.e. bacteria and oxlipin precursor). The latter will facilitate the discovery of novel mOXY. Additional bacterial biofilm assays will be performed to examine the role of mOXY in microbe-microbe interactions. To determine the contribution of mOXY in health and disease, biobanked samples from healthy volunteers and Crohns disease patients will be analysed. In vitro cell culture experiments and gene expression profiling will determine the function of mOXY in microbe-host interactions. During this project, the applicant will receive high quality training through research that will significantly improve scientific knowledge and provide a strong platform for building an independent research career. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing her potential to achieve professional maturity and leadership in the field so that she may continue to make significant contributions to society and the economy.

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The information about "OMIT" are provided by the European Opendata Portal: CORDIS opendata.

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