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OMIT SIGNED

The role of microbial Oxylipins in the MIcrobe-hosT dialogue

Total Cost €

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EC-Contrib. €

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Partnership

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 OMIT project word cloud

Explore the words cloud of the OMIT project. It provides you a very rough idea of what is the project "OMIT" about.

oxylipins    co    assays    samples    moxy    contributions    function    characterised    gene    humans    precursor    significantly    analysed    signals    competencies    roles    octadecanoids    scientific    training    bacterial    quality    career    culture    human    hoxy    omit    waters    acids    profiling    independent    vitro    gained    headquarters    incubation    ultra    chemical    man    chromatography    immune    functions    migration    continue    liquid    bacteria    signalling    microbially    interactions    supernatants    secondment    inflammation    economy    performed    latter    platform    disease    biochemical    fellowships    spectrometry    biofilm    eicosanoids    maturity    discovery    uk    contribution    expression    additional    add    mass    building    host    diversity    receive    proliferation    cell    dialogue    faecal    performance    experiments    fatty    society    reactions    healthy    mechanistic    she    appreciated    examine    crohns    biobanked    validated    platforms    leadership    oxylipin    health    liberated    ms    professional    perceived    line    microbiome    microbe    patients    oxlipin    volunteers    msca    implicit    comprising    microbial    oxidation    chemotaxis    regulators    docosanoids   

Project "OMIT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-11-09   to  2022-11-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 196˙590.00

Map

 Project objective

OMIT aims to examine the role of microbial Oxylipins in the MIcrobiome:hosT dialogue. Oxylipins liberated from the oxidation of fatty acids are appreciated as key chemical signals perceived by both microbe and man. Human oxylipins (hOXY), comprising eicosanoids, docosanoids and octadecanoids are well characterised; they are implicit in many biochemical and signalling pathways in humans, including cell migration, proliferation, chemotaxis, immune reactions and most importantly, they are key regulators of inflammation. However, the diversity, functions, impact and mechanistic roles of microbially derived oxylipins (mOXY) are not well understood. State-of-the-art ultra-performance liquid chromatography-mass spectrometry (MS) platforms (secondment at Waters MS Headquarters, UK) will be developed and validated for oxylipin analysis in faecal samples and bacterial supernatants derived from co-incubation experiments (i.e. bacteria and oxlipin precursor). The latter will facilitate the discovery of novel mOXY. Additional bacterial biofilm assays will be performed to examine the role of mOXY in microbe-microbe interactions. To determine the contribution of mOXY in health and disease, biobanked samples from healthy volunteers and Crohns disease patients will be analysed. In vitro cell culture experiments and gene expression profiling will determine the function of mOXY in microbe-host interactions. During this project, the applicant will receive high quality training through research that will significantly improve scientific knowledge and provide a strong platform for building an independent research career. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing her potential to achieve professional maturity and leadership in the field so that she may continue to make significant contributions to society and the economy.

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The information about "OMIT" are provided by the European Opendata Portal: CORDIS opendata.

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