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OMIT SIGNED

The role of microbial Oxylipins in the MIcrobe-hosT dialogue

Total Cost €

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EC-Contrib. €

0

Partnership

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 OMIT project word cloud

Explore the words cloud of the OMIT project. It provides you a very rough idea of what is the project "OMIT" about.

scientific    host    continue    fellowships    supernatants    disease    signals    biochemical    healthy    liberated    samples    ms    professional    precursor    comprising    liquid    inflammation    discovery    chemical    incubation    biobanked    performance    biofilm    maturity    chromatography    gained    crohns    receive    analysed    society    signalling    mechanistic    gene    contribution    building    acids    microbe    competencies    volunteers    she    profiling    roles    bacteria    dialogue    migration    diversity    moxy    oxylipins    humans    man    health    oxlipin    culture    validated    microbiome    function    immune    cell    platforms    performed    fatty    leadership    characterised    platform    perceived    implicit    functions    assays    line    proliferation    spectrometry    microbial    octadecanoids    headquarters    quality    co    bacterial    oxylipin    uk    ultra    appreciated    mass    interactions    expression    reactions    secondment    chemotaxis    additional    patients    independent    oxidation    significantly    microbially    latter    economy    career    hoxy    vitro    docosanoids    training    faecal    omit    contributions    add    examine    waters    experiments    regulators    human    msca    eicosanoids   

Project "OMIT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-11-09   to  2022-11-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 196˙590.00

Map

 Project objective

OMIT aims to examine the role of microbial Oxylipins in the MIcrobiome:hosT dialogue. Oxylipins liberated from the oxidation of fatty acids are appreciated as key chemical signals perceived by both microbe and man. Human oxylipins (hOXY), comprising eicosanoids, docosanoids and octadecanoids are well characterised; they are implicit in many biochemical and signalling pathways in humans, including cell migration, proliferation, chemotaxis, immune reactions and most importantly, they are key regulators of inflammation. However, the diversity, functions, impact and mechanistic roles of microbially derived oxylipins (mOXY) are not well understood. State-of-the-art ultra-performance liquid chromatography-mass spectrometry (MS) platforms (secondment at Waters MS Headquarters, UK) will be developed and validated for oxylipin analysis in faecal samples and bacterial supernatants derived from co-incubation experiments (i.e. bacteria and oxlipin precursor). The latter will facilitate the discovery of novel mOXY. Additional bacterial biofilm assays will be performed to examine the role of mOXY in microbe-microbe interactions. To determine the contribution of mOXY in health and disease, biobanked samples from healthy volunteers and Crohns disease patients will be analysed. In vitro cell culture experiments and gene expression profiling will determine the function of mOXY in microbe-host interactions. During this project, the applicant will receive high quality training through research that will significantly improve scientific knowledge and provide a strong platform for building an independent research career. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing her potential to achieve professional maturity and leadership in the field so that she may continue to make significant contributions to society and the economy.

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The information about "OMIT" are provided by the European Opendata Portal: CORDIS opendata.

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