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OMIT SIGNED

The role of microbial Oxylipins in the MIcrobe-hosT dialogue

Total Cost €

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EC-Contrib. €

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Partnership

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 OMIT project word cloud

Explore the words cloud of the OMIT project. It provides you a very rough idea of what is the project "OMIT" about.

interactions    professional    additional    economy    culture    discovery    reactions    contributions    appreciated    bacteria    assays    ultra    octadecanoids    eicosanoids    immune    expression    fatty    health    chromatography    performance    crohns    validated    precursor    characterised    significantly    faecal    disease    society    liquid    building    independent    host    gene    supernatants    mechanistic    msca    cell    mass    regulators    microbe    comprising    acids    healthy    biofilm    oxylipins    roles    microbially    bacterial    uk    quality    line    spectrometry    secondment    oxlipin    waters    ms    microbiome    add    experiments    volunteers    proliferation    headquarters    training    samples    biochemical    profiling    omit    performed    platform    incubation    diversity    function    fellowships    scientific    dialogue    gained    signals    docosanoids    maturity    competencies    biobanked    leadership    platforms    migration    continue    human    implicit    oxidation    contribution    perceived    career    receive    chemical    analysed    moxy    she    man    co    hoxy    examine    signalling    functions    oxylipin    humans    liberated    chemotaxis    vitro    patients    inflammation    latter    microbial   

Project "OMIT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-11-09   to  2022-11-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 196˙590.00

Map

 Project objective

OMIT aims to examine the role of microbial Oxylipins in the MIcrobiome:hosT dialogue. Oxylipins liberated from the oxidation of fatty acids are appreciated as key chemical signals perceived by both microbe and man. Human oxylipins (hOXY), comprising eicosanoids, docosanoids and octadecanoids are well characterised; they are implicit in many biochemical and signalling pathways in humans, including cell migration, proliferation, chemotaxis, immune reactions and most importantly, they are key regulators of inflammation. However, the diversity, functions, impact and mechanistic roles of microbially derived oxylipins (mOXY) are not well understood. State-of-the-art ultra-performance liquid chromatography-mass spectrometry (MS) platforms (secondment at Waters MS Headquarters, UK) will be developed and validated for oxylipin analysis in faecal samples and bacterial supernatants derived from co-incubation experiments (i.e. bacteria and oxlipin precursor). The latter will facilitate the discovery of novel mOXY. Additional bacterial biofilm assays will be performed to examine the role of mOXY in microbe-microbe interactions. To determine the contribution of mOXY in health and disease, biobanked samples from healthy volunteers and Crohns disease patients will be analysed. In vitro cell culture experiments and gene expression profiling will determine the function of mOXY in microbe-host interactions. During this project, the applicant will receive high quality training through research that will significantly improve scientific knowledge and provide a strong platform for building an independent research career. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing her potential to achieve professional maturity and leadership in the field so that she may continue to make significant contributions to society and the economy.

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The information about "OMIT" are provided by the European Opendata Portal: CORDIS opendata.

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