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DEFINE SIGNED

DEciphering mechanisms of presynaptic reFINEment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DEFINE project word cloud

Explore the words cloud of the DEFINE project. It provides you a very rough idea of what is the project "DEFINE" about.

interrogate    perspective    presynaptic    autism    underlies    utero    arising    neurodevelopmental    postdoctoral    obscure    axonal    periods    carefully    function    functions    refinement    modulation    unbiased    critical    impacts    synaptic    cellular    understand    underlying    therapeutic    hosting    receptor    sensory    transgenic    rnaseq    occurs    dissected    mediated    clearer    glun3a    connectivity    coordinated    restructuring    experiments    regulation    schizophrenia    nmda    trans    events    subunit    colleagues    circuits    communication    location    postsynaptic    chemogenetic    remodelling    exquisite    interhemispheric    unknown    revealing    reagents    canonical    appropriately    plays    guided    functional    dependent    deprivation    mouse    axons    intervention    follow    disorders    data    postnatal    electroporation    brain    latest    explored    callosal    assessing    mechanisms    morphological    entire    projection    circuit    molecular    completely    windows    neurological    regulate    tools    healthy    contacts    roles    perturbation   

Project "DEFINE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 172˙932.00

Map

 Project objective

The postdoctoral project aims to investigate the mechanisms underlying sensory experience driven synaptic and circuit refinement that occurs during critical periods of brain development. Presynaptic and postsynaptic refinement involving loss and strengthening of synaptic contacts are known to occur but how these processes are coordinated and remains obscure. Failure to appropriately regulate this refinement underlies some common neurological disorders including autism and schizophrenia. The non-canonical NMDA-receptor subunit GluN3A presents a likely key factor in the timely remodelling of these circuits. This project will interrogate the completely unknown roles GluN3A plays in presynaptic postnatal refinement processes. The cellular location and trans-synaptic coordination that may define these events mediated by GluN3A will be carefully dissected through analysis of interhemispheric callosal projection axons using targeted delivery of transgenic reagents by in utero electroporation in the mouse brain. Chemogenetic and sensory deprivation approaches will provide exquisite control over activity and experience dependent roles within this refinement over critical windows of development. Revealing of cellular and molecular mechanisms that GluN3A functions through in presynaptic and axonal development will be guided by unbiased RNAseq data and explored via the latest cellular and transgenic tools. Follow up experiments assessing functional connectivity, in collaboration with colleagues at the hosting institute, will help understand the impacts on circuit function and synaptic communication arising from morphological changes of GluN3A perturbation and thus understand how healthy circuits and behaviour develop. A clearer knowledge of the molecular regulation of this synaptic restructuring from the perspective of the entire circuit and its modulation by experience during development may allow for improved therapeutic intervention in neurodevelopmental disorders.

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The information about "DEFINE" are provided by the European Opendata Portal: CORDIS opendata.

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