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DEFINE SIGNED

DEciphering mechanisms of presynaptic reFINEment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DEFINE project word cloud

Explore the words cloud of the DEFINE project. It provides you a very rough idea of what is the project "DEFINE" about.

periods    remodelling    occurs    latest    events    tools    clearer    regulation    underlying    postdoctoral    axonal    trans    interrogate    circuits    neurological    follow    subunit    communication    molecular    callosal    completely    mediated    synaptic    guided    functional    chemogenetic    unknown    deprivation    postnatal    postsynaptic    carefully    utero    nmda    sensory    colleagues    mouse    presynaptic    entire    schizophrenia    rnaseq    perspective    therapeutic    perturbation    healthy    receptor    coordinated    roles    reagents    dependent    axons    autism    disorders    critical    explored    revealing    plays    transgenic    hosting    projection    glun3a    neurodevelopmental    function    arising    connectivity    obscure    windows    dissected    mechanisms    refinement    appropriately    modulation    canonical    circuit    brain    exquisite    electroporation    unbiased    location    contacts    intervention    interhemispheric    restructuring    understand    underlies    functions    impacts    regulate    experiments    assessing    cellular    morphological    data   

Project "DEFINE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 172˙932.00

Map

 Project objective

The postdoctoral project aims to investigate the mechanisms underlying sensory experience driven synaptic and circuit refinement that occurs during critical periods of brain development. Presynaptic and postsynaptic refinement involving loss and strengthening of synaptic contacts are known to occur but how these processes are coordinated and remains obscure. Failure to appropriately regulate this refinement underlies some common neurological disorders including autism and schizophrenia. The non-canonical NMDA-receptor subunit GluN3A presents a likely key factor in the timely remodelling of these circuits. This project will interrogate the completely unknown roles GluN3A plays in presynaptic postnatal refinement processes. The cellular location and trans-synaptic coordination that may define these events mediated by GluN3A will be carefully dissected through analysis of interhemispheric callosal projection axons using targeted delivery of transgenic reagents by in utero electroporation in the mouse brain. Chemogenetic and sensory deprivation approaches will provide exquisite control over activity and experience dependent roles within this refinement over critical windows of development. Revealing of cellular and molecular mechanisms that GluN3A functions through in presynaptic and axonal development will be guided by unbiased RNAseq data and explored via the latest cellular and transgenic tools. Follow up experiments assessing functional connectivity, in collaboration with colleagues at the hosting institute, will help understand the impacts on circuit function and synaptic communication arising from morphological changes of GluN3A perturbation and thus understand how healthy circuits and behaviour develop. A clearer knowledge of the molecular regulation of this synaptic restructuring from the perspective of the entire circuit and its modulation by experience during development may allow for improved therapeutic intervention in neurodevelopmental disorders.

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The information about "DEFINE" are provided by the European Opendata Portal: CORDIS opendata.

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