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DEFINE SIGNED

DEciphering mechanisms of presynaptic reFINEment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DEFINE project word cloud

Explore the words cloud of the DEFINE project. It provides you a very rough idea of what is the project "DEFINE" about.

postdoctoral    mediated    morphological    events    mechanisms    location    mouse    interhemispheric    contacts    tools    intervention    interrogate    nmda    obscure    transgenic    follow    connectivity    revealing    disorders    assessing    modulation    functional    restructuring    periods    regulate    clearer    deprivation    therapeutic    projection    receptor    axons    circuit    latest    circuits    explored    arising    completely    plays    chemogenetic    subunit    autism    trans    entire    appropriately    underlying    colleagues    perspective    hosting    function    dependent    underlies    exquisite    cellular    utero    coordinated    synaptic    unknown    occurs    refinement    electroporation    understand    functions    guided    critical    remodelling    experiments    healthy    roles    impacts    unbiased    neurological    communication    postsynaptic    brain    axonal    sensory    neurodevelopmental    presynaptic    schizophrenia    regulation    rnaseq    windows    perturbation    data    glun3a    postnatal    dissected    callosal    canonical    reagents    carefully    molecular   

Project "DEFINE" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 172˙932.00

Map

 Project objective

The postdoctoral project aims to investigate the mechanisms underlying sensory experience driven synaptic and circuit refinement that occurs during critical periods of brain development. Presynaptic and postsynaptic refinement involving loss and strengthening of synaptic contacts are known to occur but how these processes are coordinated and remains obscure. Failure to appropriately regulate this refinement underlies some common neurological disorders including autism and schizophrenia. The non-canonical NMDA-receptor subunit GluN3A presents a likely key factor in the timely remodelling of these circuits. This project will interrogate the completely unknown roles GluN3A plays in presynaptic postnatal refinement processes. The cellular location and trans-synaptic coordination that may define these events mediated by GluN3A will be carefully dissected through analysis of interhemispheric callosal projection axons using targeted delivery of transgenic reagents by in utero electroporation in the mouse brain. Chemogenetic and sensory deprivation approaches will provide exquisite control over activity and experience dependent roles within this refinement over critical windows of development. Revealing of cellular and molecular mechanisms that GluN3A functions through in presynaptic and axonal development will be guided by unbiased RNAseq data and explored via the latest cellular and transgenic tools. Follow up experiments assessing functional connectivity, in collaboration with colleagues at the hosting institute, will help understand the impacts on circuit function and synaptic communication arising from morphological changes of GluN3A perturbation and thus understand how healthy circuits and behaviour develop. A clearer knowledge of the molecular regulation of this synaptic restructuring from the perspective of the entire circuit and its modulation by experience during development may allow for improved therapeutic intervention in neurodevelopmental disorders.

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The information about "DEFINE" are provided by the European Opendata Portal: CORDIS opendata.

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