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DEciphering mechanisms of presynaptic reFINEment

Total Cost €


EC-Contrib. €






 DEFINE project word cloud

Explore the words cloud of the DEFINE project. It provides you a very rough idea of what is the project "DEFINE" about.

utero    perturbation    data    experiments    unbiased    tools    roles    circuits    axonal    postsynaptic    events    appropriately    regulate    autism    communication    impacts    reagents    therapeutic    connectivity    sensory    rnaseq    function    understand    canonical    receptor    unknown    functions    brain    entire    projection    postnatal    healthy    electroporation    chemogenetic    plays    interrogate    critical    disorders    colleagues    mouse    modulation    subunit    exquisite    glun3a    callosal    functional    trans    intervention    synaptic    assessing    underlying    occurs    explored    completely    dissected    deprivation    transgenic    morphological    underlies    mechanisms    obscure    refinement    dependent    molecular    interhemispheric    follow    revealing    neurological    neurodevelopmental    restructuring    coordinated    clearer    arising    nmda    perspective    carefully    hosting    guided    cellular    location    windows    latest    schizophrenia    contacts    postdoctoral    mediated    circuit    axons    presynaptic    periods    remodelling    regulation   

Project "DEFINE" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 172˙932 €
 EC max contribution 172˙932 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The postdoctoral project aims to investigate the mechanisms underlying sensory experience driven synaptic and circuit refinement that occurs during critical periods of brain development. Presynaptic and postsynaptic refinement involving loss and strengthening of synaptic contacts are known to occur but how these processes are coordinated and remains obscure. Failure to appropriately regulate this refinement underlies some common neurological disorders including autism and schizophrenia. The non-canonical NMDA-receptor subunit GluN3A presents a likely key factor in the timely remodelling of these circuits. This project will interrogate the completely unknown roles GluN3A plays in presynaptic postnatal refinement processes. The cellular location and trans-synaptic coordination that may define these events mediated by GluN3A will be carefully dissected through analysis of interhemispheric callosal projection axons using targeted delivery of transgenic reagents by in utero electroporation in the mouse brain. Chemogenetic and sensory deprivation approaches will provide exquisite control over activity and experience dependent roles within this refinement over critical windows of development. Revealing of cellular and molecular mechanisms that GluN3A functions through in presynaptic and axonal development will be guided by unbiased RNAseq data and explored via the latest cellular and transgenic tools. Follow up experiments assessing functional connectivity, in collaboration with colleagues at the hosting institute, will help understand the impacts on circuit function and synaptic communication arising from morphological changes of GluN3A perturbation and thus understand how healthy circuits and behaviour develop. A clearer knowledge of the molecular regulation of this synaptic restructuring from the perspective of the entire circuit and its modulation by experience during development may allow for improved therapeutic intervention in neurodevelopmental disorders.

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The information about "DEFINE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-08-09 1:06:57) correctly updated