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BiLamVesicles SIGNED

Novel bi-lamellar lipid vesicles for studying double-membrane transenvelope proteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BiLamVesicles project word cloud

Explore the words cloud of the BiLamVesicles project. It provides you a very rough idea of what is the project "BiLamVesicles" about.

regulated    vesicles    bacteria    ground    efflux    surface    assembly    life    time    transport    gram    ubiquitous    assembled    isolate    drug    integrate    host    nucleus    assays    once    tool    biotechnological    combine    inaccessible    lack    proteins    escherichia    biologically    full    chip    techniques    bacterial    lipid    boundaries    insertion    rates    coli    protein    composition    pump    hosting    remarkable    double    span    optofluidic    domains    acrab    tolc    framework    quantify    cellular    bi    multidrug    expertise    interactions    pave    lamellar    models    transporter    machineries    microfluidic    envelopes    model    single    layer    breaking    first    bilamvesicles    naturally    chemistry    employ    fundamental    vesicle    entire    microfluidics    synergy    screening    membrane    membranes    restricted    accommodating    biophysics    archetype    suitable    accommodate    environment    technique    negative    exquisite    stretch    envelope   

Project "BiLamVesicles" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 224˙933.00

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 Project objective

Double membranes are ubiquitous throughout the domains of life, accommodating remarkable protein machineries which are fundamental to the cellular activity. However, the study of these proteins is restricted by the lack of a suitable membrane model to accommodate them. Within the framework of BiLamVesicles I will develop a novel bi-lamellar lipid vesicle as a tool for hosting and studying proteins which naturally span across double membranes such as the nucleus and Gram-negative bacteria envelopes. To integrate the protein of choice within the vesicle envelope I will design and employ a highly regulated layer-by-layer assembly in a microfluidic chip. This approach will combine the host’s expertise in microfluidics and biophysics with my expertise in surface interactions and surface chemistry to allow an exquisite control over the membrane composition of bi-lamellar vesicles and the protein insertion process. Once assembled, I will use these vesicles to study the activity of the entire Gram-negative bacterial transporter system AcrAB-TolC, an archetype multidrug efflux pump of Escherichia coli. I will spatially isolate vesicles in a microfluidic chip and directly quantify transport rates through a full efflux pump system at the single-vesicle-level for the first time, using an advanced optofluidic system. The synergy between microfluidics and the proposed double membrane vesicles will produce a ground-breaking biotechnological technique for studying the activity of as yet inaccessible proteins in a biologically-relevant environment. This research will stretch the existing boundaries set by current membrane models and will pave the way for developing advanced techniques for drug screening assays.

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