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BiLamVesicles SIGNED

Novel bi-lamellar lipid vesicles for studying double-membrane transenvelope proteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BiLamVesicles project word cloud

Explore the words cloud of the BiLamVesicles project. It provides you a very rough idea of what is the project "BiLamVesicles" about.

time    coli    transport    breaking    acrab    accommodating    lipid    membranes    stretch    host    environment    isolate    chip    once    assays    technique    insertion    employ    lamellar    envelope    first    quantify    vesicle    fundamental    lack    suitable    interactions    ground    double    boundaries    pump    layer    pave    single    model    accommodate    protein    nucleus    restricted    synergy    negative    biologically    life    bacteria    exquisite    combine    regulated    biotechnological    biophysics    surface    vesicles    rates    bacterial    inaccessible    domains    transporter    machineries    optofluidic    archetype    proteins    composition    models    entire    chemistry    microfluidics    screening    gram    envelopes    framework    escherichia    ubiquitous    cellular    hosting    efflux    bilamvesicles    bi    tool    remarkable    full    span    drug    expertise    microfluidic    assembly    multidrug    techniques    tolc    membrane    integrate    naturally    assembled   

Project "BiLamVesicles" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 224˙933.00

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 Project objective

Double membranes are ubiquitous throughout the domains of life, accommodating remarkable protein machineries which are fundamental to the cellular activity. However, the study of these proteins is restricted by the lack of a suitable membrane model to accommodate them. Within the framework of BiLamVesicles I will develop a novel bi-lamellar lipid vesicle as a tool for hosting and studying proteins which naturally span across double membranes such as the nucleus and Gram-negative bacteria envelopes. To integrate the protein of choice within the vesicle envelope I will design and employ a highly regulated layer-by-layer assembly in a microfluidic chip. This approach will combine the host’s expertise in microfluidics and biophysics with my expertise in surface interactions and surface chemistry to allow an exquisite control over the membrane composition of bi-lamellar vesicles and the protein insertion process. Once assembled, I will use these vesicles to study the activity of the entire Gram-negative bacterial transporter system AcrAB-TolC, an archetype multidrug efflux pump of Escherichia coli. I will spatially isolate vesicles in a microfluidic chip and directly quantify transport rates through a full efflux pump system at the single-vesicle-level for the first time, using an advanced optofluidic system. The synergy between microfluidics and the proposed double membrane vesicles will produce a ground-breaking biotechnological technique for studying the activity of as yet inaccessible proteins in a biologically-relevant environment. This research will stretch the existing boundaries set by current membrane models and will pave the way for developing advanced techniques for drug screening assays.

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The information about "BILAMVESICLES" are provided by the European Opendata Portal: CORDIS opendata.

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