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SmartSAST SIGNED

Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SmartSAST project word cloud

Explore the words cloud of the SmartSAST project. It provides you a very rough idea of what is the project "SmartSAST" about.

good    isomeric    sonogens    shifting    characterization    photochemical    operative    time    sound    easily    probe    benefits    dynamics    protein    combines    light    isomerizable    refreshed    individuation    strategies    communication    ultrasounds    operate    living    compelling    optical    multicomponent    supramolecular    unresolved    background    designing    appealing    advancements    photoacoustic    modulating    ensures    benefit    multiplexing    tags    setups    stage    combination    bases    cancers    imparts    invasiveness    invasively    visualizing    kinetic    biological    signatures    organic    thermokinetic    photoresponsive    fundamentals    penetration    nature    input    microbiomes    imaging    organization    guarantees    smart    extracting    modularity    progress    substituted    bind    complexity    probes    unlock    spatial    named    indispensable    pai    photo    activated    roots    suitable    assembly    contrast    unprecedented    absorption    secure    dynamic    resolution    output    covalently    engineering    detector    smartsast    invasive    rationally    form    deeply    chromophores    science    synthesis   

Project "SmartSAST" data sheet

The following table provides information about the project.

Coordinator
ECOLE NORMALE SUPERIEURE 

Organization address
address: 45, RUE D'ULM
city: PARIS CEDEX 05
postcode: 75230
website: http://www.ens.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NORMALE SUPERIEURE FR (PARIS CEDEX 05) coordinator 184˙707.00

Map

 Project objective

Visualizing the complexity of living matter non-invasively and with high-resolution represents an indispensable element for progress in science. Unresolved issues as the individuation of early-stage cancers, or the spatial organization of the roots microbiomes, can benefit from advancements in photoacoustic imaging (PAI). This appealing technology combines the benefits of light as input and ultrasounds as output, offering a compelling combination of good resolution, high penetration depth, and non-invasiveness. However, PAI is not suitable to study multicomponent living systems because current strategies operate with simple probe-detector setups. With SmartSAST (Smart Sound-activated Absorption Shifting Tags), I propose to enable modularity and multiplexing through the development of photoacoustic probes based on protein tags that non-covalently bind with photoresponsive organic chromophores named sonogens. The supramolecular nature of SmartSAST ensures great modularity as the sonogens can be easily refreshed or substituted. The change in optical properties of the probes upon assembly guarantees great contrast against the background. Finally, via rationally designing photo-isomerizable sonogens that bind the protein just in a specific isomeric form, SmartSAST imparts an unprecedented level of control in PAI. Upon photo-modulating the supramolecular dynamics of these probes and extracting their kinetic signatures, dynamic contrast and multiplexing will be achieved with high spatial resolution. SmartSAST project aims to develop a fully operative technology based on new fundamentals bases. The project includes the synthesis of sonogens, the engineering of protein tags, the thermokinetic and photochemical characterization of the probes and their application in PAI. This new approach to PAI will unlock the non-invasive study of deeply embedded complex biological targets in real-time. Dissemination and communication activities will secure the great impact of SmartSAST.

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The information about "SMARTSAST" are provided by the European Opendata Portal: CORDIS opendata.

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