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SmartSAST SIGNED

Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartSAST project word cloud

Explore the words cloud of the SmartSAST project. It provides you a very rough idea of what is the project "SmartSAST" about.

ensures    nature    covalently    benefits    tags    benefit    appealing    invasively    guarantees    dynamic    rationally    background    multicomponent    visualizing    unlock    stage    advancements    invasive    dynamics    operate    biological    probes    good    resolution    time    individuation    smart    microbiomes    imaging    unprecedented    communication    invasiveness    roots    isomerizable    detector    modularity    probe    absorption    modulating    supramolecular    setups    bases    combination    photoresponsive    penetration    imparts    ultrasounds    kinetic    suitable    bind    complexity    photo    form    deeply    organization    spatial    substituted    fundamentals    protein    designing    light    named    sound    contrast    signatures    characterization    assembly    secure    photochemical    sonogens    photoacoustic    combines    easily    living    shifting    cancers    smartsast    isomeric    refreshed    multiplexing    operative    indispensable    output    engineering    thermokinetic    activated    strategies    organic    science    pai    unresolved    input    compelling    synthesis    extracting    progress    chromophores    optical   

Project "SmartSAST" data sheet

The following table provides information about the project.

Coordinator		 ECOLE NORMALE SUPERIEURE 

Organization address
address: 45, RUE D'ULM
city: PARIS CEDEX 05
postcode: 75230
website: http://www.ens.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NORMALE SUPERIEURE FR (PARIS CEDEX 05) coordinator 184˙707.00

Map

 Project objective

Visualizing the complexity of living matter non-invasively and with high-resolution represents an indispensable element for progress in science. Unresolved issues as the individuation of early-stage cancers, or the spatial organization of the roots microbiomes, can benefit from advancements in photoacoustic imaging (PAI). This appealing technology combines the benefits of light as input and ultrasounds as output, offering a compelling combination of good resolution, high penetration depth, and non-invasiveness. However, PAI is not suitable to study multicomponent living systems because current strategies operate with simple probe-detector setups. With SmartSAST (Smart Sound-activated Absorption Shifting Tags), I propose to enable modularity and multiplexing through the development of photoacoustic probes based on protein tags that non-covalently bind with photoresponsive organic chromophores named sonogens. The supramolecular nature of SmartSAST ensures great modularity as the sonogens can be easily refreshed or substituted. The change in optical properties of the probes upon assembly guarantees great contrast against the background. Finally, via rationally designing photo-isomerizable sonogens that bind the protein just in a specific isomeric form, SmartSAST imparts an unprecedented level of control in PAI. Upon photo-modulating the supramolecular dynamics of these probes and extracting their kinetic signatures, dynamic contrast and multiplexing will be achieved with high spatial resolution. SmartSAST project aims to develop a fully operative technology based on new fundamentals bases. The project includes the synthesis of sonogens, the engineering of protein tags, the thermokinetic and photochemical characterization of the probes and their application in PAI. This new approach to PAI will unlock the non-invasive study of deeply embedded complex biological targets in real-time. Dissemination and communication activities will secure the great impact of SmartSAST.

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The information about "SMARTSAST" are provided by the European Opendata Portal: CORDIS opendata.

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