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Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Total Cost €


EC-Contrib. €






 SmartSAST project word cloud

Explore the words cloud of the SmartSAST project. It provides you a very rough idea of what is the project "SmartSAST" about.

nature    contrast    isomeric    supramolecular    photoresponsive    deeply    refreshed    benefits    dynamic    bind    science    pai    roots    living    photo    absorption    imaging    combines    cancers    activated    appealing    designing    indispensable    suitable    photochemical    setups    engineering    unresolved    protein    modulating    photoacoustic    resolution    detector    synthesis    kinetic    named    substituted    microbiomes    fundamentals    ensures    progress    easily    operate    secure    combination    biological    modularity    multicomponent    organic    spatial    background    penetration    sonogens    dynamics    invasive    characterization    communication    organization    smart    stage    shifting    assembly    input    operative    unlock    time    extracting    invasively    advancements    good    strategies    imparts    probe    optical    rationally    form    light    multiplexing    complexity    benefit    output    tags    visualizing    signatures    individuation    sound    compelling    invasiveness    chromophores    probes    unprecedented    isomerizable    guarantees    smartsast    covalently    thermokinetic    bases    ultrasounds   

Project "SmartSAST" data sheet

The following table provides information about the project.


Organization address
address: 45, RUE D'ULM
city: PARIS CEDEX 05
postcode: 75230

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NORMALE SUPERIEURE FR (PARIS CEDEX 05) coordinator 184˙707.00


 Project objective

Visualizing the complexity of living matter non-invasively and with high-resolution represents an indispensable element for progress in science. Unresolved issues as the individuation of early-stage cancers, or the spatial organization of the roots microbiomes, can benefit from advancements in photoacoustic imaging (PAI). This appealing technology combines the benefits of light as input and ultrasounds as output, offering a compelling combination of good resolution, high penetration depth, and non-invasiveness. However, PAI is not suitable to study multicomponent living systems because current strategies operate with simple probe-detector setups. With SmartSAST (Smart Sound-activated Absorption Shifting Tags), I propose to enable modularity and multiplexing through the development of photoacoustic probes based on protein tags that non-covalently bind with photoresponsive organic chromophores named sonogens. The supramolecular nature of SmartSAST ensures great modularity as the sonogens can be easily refreshed or substituted. The change in optical properties of the probes upon assembly guarantees great contrast against the background. Finally, via rationally designing photo-isomerizable sonogens that bind the protein just in a specific isomeric form, SmartSAST imparts an unprecedented level of control in PAI. Upon photo-modulating the supramolecular dynamics of these probes and extracting their kinetic signatures, dynamic contrast and multiplexing will be achieved with high spatial resolution. SmartSAST project aims to develop a fully operative technology based on new fundamentals bases. The project includes the synthesis of sonogens, the engineering of protein tags, the thermokinetic and photochemical characterization of the probes and their application in PAI. This new approach to PAI will unlock the non-invasive study of deeply embedded complex biological targets in real-time. Dissemination and communication activities will secure the great impact of SmartSAST.

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The information about "SMARTSAST" are provided by the European Opendata Portal: CORDIS opendata.

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