Opendata, web and dolomites

SmartSAST SIGNED

Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SmartSAST project word cloud

Explore the words cloud of the SmartSAST project. It provides you a very rough idea of what is the project "SmartSAST" about.

combines    organic    tags    resolution    smart    chromophores    advancements    complexity    contrast    living    setups    bases    modularity    covalently    organization    invasively    unprecedented    spatial    microbiomes    signatures    individuation    operative    appealing    activated    invasiveness    sound    science    fundamentals    optical    penetration    designing    rationally    dynamics    assembly    synthesis    sonogens    combination    output    modulating    deeply    multicomponent    suitable    light    biological    unlock    input    shifting    guarantees    imparts    kinetic    roots    named    easily    stage    benefit    photochemical    operate    protein    good    photoacoustic    indispensable    characterization    pai    ultrasounds    progress    unresolved    isomerizable    time    compelling    form    communication    nature    imaging    engineering    dynamic    thermokinetic    extracting    probes    ensures    strategies    smartsast    bind    probe    multiplexing    supramolecular    isomeric    invasive    benefits    absorption    substituted    visualizing    photo    detector    photoresponsive    secure    refreshed    cancers    background   

Project "SmartSAST" data sheet

The following table provides information about the project.

Coordinator
ECOLE NORMALE SUPERIEURE 

Organization address
address: 45, RUE D'ULM
city: PARIS CEDEX 05
postcode: 75230
website: http://www.ens.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NORMALE SUPERIEURE FR (PARIS CEDEX 05) coordinator 184˙707.00

Map

 Project objective

Visualizing the complexity of living matter non-invasively and with high-resolution represents an indispensable element for progress in science. Unresolved issues as the individuation of early-stage cancers, or the spatial organization of the roots microbiomes, can benefit from advancements in photoacoustic imaging (PAI). This appealing technology combines the benefits of light as input and ultrasounds as output, offering a compelling combination of good resolution, high penetration depth, and non-invasiveness. However, PAI is not suitable to study multicomponent living systems because current strategies operate with simple probe-detector setups. With SmartSAST (Smart Sound-activated Absorption Shifting Tags), I propose to enable modularity and multiplexing through the development of photoacoustic probes based on protein tags that non-covalently bind with photoresponsive organic chromophores named sonogens. The supramolecular nature of SmartSAST ensures great modularity as the sonogens can be easily refreshed or substituted. The change in optical properties of the probes upon assembly guarantees great contrast against the background. Finally, via rationally designing photo-isomerizable sonogens that bind the protein just in a specific isomeric form, SmartSAST imparts an unprecedented level of control in PAI. Upon photo-modulating the supramolecular dynamics of these probes and extracting their kinetic signatures, dynamic contrast and multiplexing will be achieved with high spatial resolution. SmartSAST project aims to develop a fully operative technology based on new fundamentals bases. The project includes the synthesis of sonogens, the engineering of protein tags, the thermokinetic and photochemical characterization of the probes and their application in PAI. This new approach to PAI will unlock the non-invasive study of deeply embedded complex biological targets in real-time. Dissemination and communication activities will secure the great impact of SmartSAST.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SMARTSAST" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SMARTSAST" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More