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SmartSAST SIGNED

Non-covalent photoresponsive tags for photoacoustic imaging: Giving voice to living matter

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SmartSAST project word cloud

Explore the words cloud of the SmartSAST project. It provides you a very rough idea of what is the project "SmartSAST" about.

form    isomeric    roots    activated    dynamic    cancers    signatures    sound    time    compelling    setups    modularity    visualizing    named    organization    unresolved    good    pai    invasive    characterization    designing    photochemical    ultrasounds    protein    fundamentals    easily    photoresponsive    substituted    rationally    extracting    dynamics    probe    science    synthesis    deeply    photo    kinetic    complexity    benefit    smart    combination    smartsast    thermokinetic    detector    light    covalently    imparts    penetration    unprecedented    invasively    refreshed    indispensable    advancements    microbiomes    input    secure    strategies    unlock    biological    resolution    operative    isomerizable    suitable    probes    multiplexing    living    optical    operate    output    supramolecular    spatial    organic    chromophores    tags    benefits    modulating    individuation    nature    appealing    bind    contrast    photoacoustic    shifting    communication    guarantees    invasiveness    ensures    absorption    multicomponent    bases    assembly    sonogens    progress    background    combines    imaging    engineering    stage   

Project "SmartSAST" data sheet

The following table provides information about the project.

Coordinator		 ECOLE NORMALE SUPERIEURE 

Organization address
address: 45, RUE D'ULM
city: PARIS CEDEX 05
postcode: 75230
website: http://www.ens.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Total cost 184˙707 €
 EC max contribution 184˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NORMALE SUPERIEURE FR (PARIS CEDEX 05) coordinator 184˙707.00

Map

 Project objective

Visualizing the complexity of living matter non-invasively and with high-resolution represents an indispensable element for progress in science. Unresolved issues as the individuation of early-stage cancers, or the spatial organization of the roots microbiomes, can benefit from advancements in photoacoustic imaging (PAI). This appealing technology combines the benefits of light as input and ultrasounds as output, offering a compelling combination of good resolution, high penetration depth, and non-invasiveness. However, PAI is not suitable to study multicomponent living systems because current strategies operate with simple probe-detector setups. With SmartSAST (Smart Sound-activated Absorption Shifting Tags), I propose to enable modularity and multiplexing through the development of photoacoustic probes based on protein tags that non-covalently bind with photoresponsive organic chromophores named sonogens. The supramolecular nature of SmartSAST ensures great modularity as the sonogens can be easily refreshed or substituted. The change in optical properties of the probes upon assembly guarantees great contrast against the background. Finally, via rationally designing photo-isomerizable sonogens that bind the protein just in a specific isomeric form, SmartSAST imparts an unprecedented level of control in PAI. Upon photo-modulating the supramolecular dynamics of these probes and extracting their kinetic signatures, dynamic contrast and multiplexing will be achieved with high spatial resolution. SmartSAST project aims to develop a fully operative technology based on new fundamentals bases. The project includes the synthesis of sonogens, the engineering of protein tags, the thermokinetic and photochemical characterization of the probes and their application in PAI. This new approach to PAI will unlock the non-invasive study of deeply embedded complex biological targets in real-time. Dissemination and communication activities will secure the great impact of SmartSAST.

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The information about "SMARTSAST" are provided by the European Opendata Portal: CORDIS opendata.

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