KRAB-ZNF

KRAB zinc finger gene biology in evolution and disease

Coordinatore	UNIVERSITAET ROSTOCK    more  Organization address address: UNIVERSITATSPLATZ 1 city: ROSTOCK postcode: 18051 contact info Titolo: Prof. Nome: Hans-Juergen Cognome: Thiesen Email: send email Telefono: +49 381 4945870 Fax: +49 381 4945882
Nazionalità Coordinatore	Germany [DE]
Totale costo	243˙600 €
EC contributo	243˙600 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IRSES
Funding Scheme	MC-IRSES
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-07-01   -   2015-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITAET ROSTOCK  Organization address address: UNIVERSITATSPLATZ 1 city: ROSTOCK postcode: 18051 contact info Titolo: Prof. Nome: Hans-Juergen Cognome: Thiesen Email: send email Telefono: +49 381 4945870 Fax: +49 381 4945882	DE (ROSTOCK)	coordinator	88˙200.00
2	LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS KNOELL INSTITUTE  Organization address address: Beutenbergstrasse 11a city: JENA postcode: 7745 contact info Titolo: Dr. Nome: Reinhard Cognome: Guthke Email: send email Telefono: +49 3641 5321083 Fax: +49 3641 5320803	DE (JENA)	participant	69˙300.00
3	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Dr. Nome: Karin Cognome: Isler Email: send email Telefono: +41 44 6355401 Fax: +41 44 6356804	CH (ZURICH)	participant	46˙200.00
4	UNIVERSITAETSKLINIKUM BONN  Organization address address: Sigmund-Freud-Strasse 25 city: BONN postcode: 53105 contact info Titolo: Prof. Nome: Glen Cognome: Kristiansen Email: send email Telefono: +49 228 287 15375	DE (BONN)	participant	39˙900.00

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 Obiettivo del progetto (Objective)

'The „KRAB-ZNF“ initiative is driven by recent observations that KRAB-ZNF genes, an evolutionarily conserved gene family of more than 350 transcriptional repressors encoded in the human genome, are predominantly expressed in testis and fetal brain. To elucidate functions of KRAB ZNF genes in evolution and diseases, experts in KRAB ZNF gene biology (B1/P1), proteomics (B1/P2), systems biology and aging (B2/P3), interspecies brain life histories (B3/P4), primate socioecology (B3/P5), human pathology (B3/P6) and in any aspect of computational biology (B4/P7-B6/P11) have established a well-coordinated interdisciplinary exchange program between German (B1,B2/P1-P3), Swiss (B3,P4-P6) and Chinese (B4/P7-B6/P11) institutions. Bioinformatic expertise encompasses network analysis (B4/P7 and B6/P10), molecular structure modeling (B5/P9), database design (B4/P8), and deep sequencing bioinformatics (B6/P11). Workpackages with defined topics are focused on the toponome analysis of KRAB ZNF protein expression (WP1), studying KRAB-ZNF interactions with TRIM28 (WP2), relating KRAB-ZNF gene functions to longevity (WP3), comparing brain sizes, fertility, cognitive behaviours and other aspects of life histories from birds to mammals (WP4), correlating SNPs of brain-related genes with social behaviour of e.g. primates (WP5), and on studying KRAB ZNF protein and related target proteins thereof in human pathology (WP6). The experimental data (B1/P1-B3/P6) will be analyzed in conjunction with experts in bioinformatics (B4/P7-B6/P11), compared to existing world-wide-knowledge (WP7), upon perturbation by small molecules (WP8), modeled upon protein interaction data (WP9), assembled in comprehensive databases (WP10), and finally analyzed phylogenomically (WP11). Within the requested funding period of 48 months, the “KRAB-ZNF” initiative is expected to achieve major contributions in elucidating KRAB ZNF gene functions in primate evolution, ontogenesis, neural development, longevity and disease.'