CEREBRAD

Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation

 Coordinatore STUDIECENTRUM VOOR KERNENERGIE 

 Organization address address: Herrmann Debrouxlaan 40
city: Brussel
postcode: 1160

contact info
Titolo: Dr.
Nome: Nathalie
Cognome: Impens
Email: send email
Telefono: +32 14 332845

 Nazionalità Coordinatore Belgium [BE]
 Sito del progetto http://www.cerebrad-fp7.eu/
 Totale costo 4˙905˙635 €
 EC contributo 2˙999˙516 €
 Programma FP7-EURATOM-FISSION
EURATOM: Nuclear fission and radiation protection
 Code Call FP7-Fission-2011
 Funding Scheme CP-FP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-10-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    STUDIECENTRUM VOOR KERNENERGIE

 Organization address address: Herrmann Debrouxlaan 40
city: Brussel
postcode: 1160

contact info
Titolo: Dr.
Nome: Nathalie
Cognome: Impens
Email: send email
Telefono: +32 14 332845

BE (Brussel) coordinator 672˙567.00
2    UNIVERSITAT ROVIRA I VIRGILI

 Organization address address: CARRER DE ESCORXADOR
city: TARRAGONA
postcode: 43003

contact info
Titolo: Dr.
Nome: Victoria
Cognome: Linares Vidal
Email: send email
Telefono: +34 977 759374
Fax: +34 977 759322

ES (TARRAGONA) participant 300˙000.00
3    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Ms.
Nome: Riet
Cognome: Van Zeijl
Email: send email
Telefono: +31 10 7044743
Fax: 31107044743

NL (ROTTERDAM) participant 280˙500.00
4    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

 Organization address address: Ingolstaedter Landstrasse 1
city: MUENCHEN
postcode: 85764

contact info
Titolo: Dr.
Nome: Jürgen
Cognome: Ertel
Email: send email
Telefono: +49 89 3187 3022

DE (MUENCHEN) participant 270˙000.00
5    ORSZAGOS KOZEGESZSEGUGYI KOZPONT

 Organization address address: GYALI UTCA 26-6
city: BUDAPEST
postcode: 1097

contact info
Titolo: Dr.
Nome: Geza
Cognome: Safrany
Email: send email
Telefono: +36 1 4822001

HU (BUDAPEST) participant 270˙000.00
6    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Prof.
Nome: Ingvar
Cognome: Brandt
Email: send email
Telefono: +46 18 4712622

SE (UPPSALA) participant 269˙832.00
7    INSTITUT GUSTAVE ROUSSY

 Organization address address: Rue Camille Desmoulins 39
city: VILLEJUIF
postcode: 94805

contact info
Titolo: Mr.
Nome: Arnauld
Cognome: Forest
Email: send email
Telefono: +33 1 42 11 66 04
Fax: +33 1 42 11 61 60

FR (VILLEJUIF) participant 249˙800.00
8    AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE,L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE

 Organization address address: Lungotevere Grande Ammiraglio Thaon di Revel 76
city: ROMA
postcode: 196

contact info
Titolo: Dr.
Nome: Simonetta
Cognome: Pazzaglia
Email: send email
Telefono: 390630000000
Fax: 390630000000

IT (ROMA) participant 219˙965.00
9    ARISTOTELIO PANEPISTIMIO THESSALONIKIS

 Organization address address: Administration Building, University Campus
city: THESSALONIKI
postcode: 54124

contact info
Titolo: Ms.
Nome: Georgia
Cognome: Petridou
Email: send email
Telefono: 302311000000
Fax: 302311000000

EL (THESSALONIKI) participant 216˙852.80
10    THE UNIVERSITY OF BIRMINGHAM

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Ms.
Nome: May
Cognome: Chung
Email: send email
Telefono: +44 1214158202
Fax: +44 1214146056

UK (BIRMINGHAM) participant 150˙000.00
11    STATE INSTITUTION RESEARCH CENTER FOR RADIATION MEDICINE OF THE ACADEMY OF MEDICAL SCIENCES OF UKRAINE

 Organization address address: MELNIKOVA STREET 53
city: KYIV
postcode: 4050

contact info
Titolo: Prof.
Nome: Dimitry
Cognome: Bazyka
Email: send email
Telefono: +38 44 4518294

UA (KYIV) participant 100˙000.00
12    ORSZAGOS FREDERIC JOLIOT-CURIE SUGARBIOLOGIAI ES SUGAREGESZSEGUGYI KUTATO INTEZET

 Organization address address: ANNA U 5
city: BUDAPEST
postcode: 1221

contact info
Titolo: Dr.
Nome: Geza
Cognome: Safrany
Email: send email
Telefono: +36 1 4822001

HU (BUDAPEST) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

postnatal    diseases    risks    exposures    below    radiation    impairment    agenda    molecular    determine    pollutants    environmental    biological    cerebrovascular    internal    exposure    inform    effect    ionising    dose    exposed    receiving    animal    cognitive    health    irradiation    special    liquidators    utero    induced    doses    external    cerebrad    indicate    brain    preliminary    chernobyl    experimental    risk    cancer    scientific    tests    protection    epidemiological    data    combined    radiotherapy   

 Obiettivo del progetto (Objective)

'The major elements of scientific uncertainty in the context of radiation protection policy and of risk assessment for cerebrovascular diseases, set the following key topics (1) the direct assessment of health effects through epidemiological studies of groups exposed to low doses, (2) doses-response and biological effects from different types of radiation and (3) the biological processes in cells and tissues mediating the cerebrovascular effects of low-dose radiation. These 3 topics have been identified as priorities by the HLEG, the MELODI Strategic Agenda and ARCH (Agenda for Research on Chernobyl Health), and will be covered in the CEREBRAD (Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation) project. CEREBRAD will address the problem of cerebrovascular effects in humans: in individuals that were exposed in utero, in cohorts of adults from the Chernobyl liquidators, and in children receiving low doses to the brain during cancer radiotherapy. We will study cognitive effects in animal models exposed to radiation at different stages of brain development, with special emphasis on early postnatal exposures, and will examine the initial and late effects induced in brain by irradiation at the cellular and molecular levels. The main concern of CEREBRAD is to identify the potential risk of doses below 100 mGy delivered to a young child. To inform on risk estimates of the effect from internal and external exposures, as well as synergistic effect with other environmental pollutants, all these different conditions will be evaluated. The consortium is an interdisciplinary team of radiobiologists, epidemiologists, experts in neurodegenerative diseases, genomics, proteomics and bioinformatics, paediatricians and dosimetrists. Special attention will be paid to efficient project management, training, dissemination and communication with stakeholders and the general public.'

Introduzione (Teaser)

European scientists are combining experimental work with epidemiological data to identify the potential health risks associated with exposure to low-dose ionising radiation.

Descrizione progetto (Article)

Exposure to ionising radiation is linked to cancer development. However, at low doses, other potential risks such as effects on brain development and cerebrovascular disease have been largely neglected. In particular, exposure to radiation in utero, or as a result of the Chernobyl accident or childhood cancer radiotherapy, needs to be assessed to determine the risk of developing cerebrovascular diseases.

The key objective of the EU-funded 'Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation' (http://www.cerebrad-fp7.eu/en (CEREBRAD)) project is to investigate the long-term cognitive and cerebrovascular risks of low-dose ionising radiation. So far, the consortium has collected data from Chernobyl liquidators as well as in utero-exposed subjects. Interviews of the postnatal-exposed cohort showed preliminary data that indicated mild cognitive impairment in nearly 40 % and vascular dementia in 15 % of the cases. Cognitive and neuropsychological tests on radiotherapy patients treated for haemangioma and having received low-dose radiation to the brain are ongoing.

This data is being combined with experimental studies in animals receiving different doses of ionising radiation. Using specific behaviour tests, researchers have analysed the cognitive and cerebrovascular effects of low-dose radiation. Despite the fact that that preliminary data indicate a dose threshold below which no severe cognitive impairment could occur, subtle changes in working strategy and other functions related to the pre-frontal cortex appear to be modulated at low doses. At the molecular level, radiation has been found to cause neuro-inflammation and glial activation that perturbs neuronal equilibrium and impairs neurogenesis.

Dosimetric investigations on animal foetuses indicate that the energy deposited in soft tissue and bone is dependent on whether the radiation source is internal or external. In light of the observed radiation response, the role of combined exposure with environmental pollutants will also be assessed.

Taken together, the activities of the CEREBRAD study will determine the outcome of low-dose radiation and help calculate organ doses after partial or whole-body irradiation. The generated scientific evidence will be used to inform the radiation protection communities and regulatory bodies about the long-term risks associated with low-dose radiation.

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