TARKINAID

Targeting Src-family tyrosine kinases in chronic autoimmune and inflammatory diseases

 Coordinatore SEMMELWEIS EGYETEM 

 Organization address address: Ulloi ut 26
city: BUDAPEST
postcode: 1085

contact info
Titolo: Prof.
Nome: Miklós
Cognome: Tóth
Email: send email
Telefono: +361 266 0791
Fax: +361 266 0791

 Nazionalità Coordinatore Hungary [HU]
 Totale costo 3˙912˙000 €
 EC contributo 2˙999˙860 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2011-single-stage
 Funding Scheme CP-FP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-01-01   -   2015-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    SEMMELWEIS EGYETEM

 Organization address address: Ulloi ut 26
city: BUDAPEST
postcode: 1085

contact info
Titolo: Prof.
Nome: Miklós
Cognome: Tóth
Email: send email
Telefono: +361 266 0791
Fax: +361 266 0791

HU (BUDAPEST) coordinator 551˙962.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Markus
Cognome: Sperandio
Email: send email
Telefono: +49 89 2180 76505
Fax: +49 89 2180 76503

DE (MUENCHEN) participant 493˙280.00
3    UNIVERSITA DEGLI STUDI DI VERONA

 Organization address address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129

contact info
Titolo: Dr.
Nome: Enrico Maria
Cognome: Cazzaroli
Email: send email
Telefono: +39 045 8126446
Fax: +39 045 8126446

IT (VERONA) participant 296˙082.00
4    VICHEM CHEMIE KUTATO KFT

 Organization address address: HERMANN OTTO UTCA 15
city: BUDAPEST
postcode: 1022

contact info
Titolo: Mr.
Nome: Zoltán
Cognome: Dobai
Email: send email
Telefono: +36 1 4872080

HU (BUDAPEST) participant 296˙010.00
5    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Ms.
Nome: Armelle
Cognome: Barelli
Email: send email
Telefono: +33 561336080
Fax: +33 562172901

FR (PARIS) participant 295˙950.00
6    UNIVERSIDADE FEDERAL DO RIO DE JANEIRO

 Organization address address: AV BRIGADEIRO TROMPOWSKI SN 2
city: RIO DE JANEIRO
postcode: 21941 590

contact info
Titolo: Ms.
Nome: Marta
Cognome: Farias
Email: send email
Telefono: +5521 2562 6527
Fax: +5521 2280 8193

BR (RIO DE JANEIRO) participant 246˙822.00
7    UNIVERSITAETSKLINIKUM FREIBURG

 Organization address address: HUGSTETTER STRASSE 49
city: FREIBURG
postcode: 79106

contact info
Titolo: Mr.
Nome: Jürgen
Cognome: Dreyer
Email: send email
Telefono: +49 761 270 20810
Fax: +49 761 270 18890

DE (FREIBURG) participant 246˙228.00
8    BIOMEDCODE ELLAS ANONIMI ETERIA EPISTIMONIKIS KAI TEXNOLOGIKIS EREVNASKAI EMBORIKIS EKMETALLEFSIS EPHARMOGON IATRIKIS

 Organization address address: ALEXANDER FLEMING STREET 34
city: VARI
postcode: 16672

contact info
Titolo: Dr.
Nome: Piyi
Cognome: Papadaki
Email: send email
Telefono: +30 210 9656310
Fax: +30 210 9656563

EL (VARI) participant 177˙570.00
9    AMBIOTIS SAS

 Organization address address: RUE JEANNE MARVIG 29
city: TOULOUSE
postcode: 31400

contact info
Titolo: Dr.
Nome: Marc
Cognome: Dubourdeau
Email: send email
Telefono: 33562244157

FR (TOULOUSE) participant 147˙978.00
10    FUNDACAO OSWALDO CRUZ

 Organization address address: AVENIDA BRASIL 4365
city: RIO DE JANEIRO
postcode: 21040 900

contact info
Titolo: Dr.
Nome: Adolfo Horácio
Cognome: Chorny
Email: send email
Telefono: +5521 22092252
Fax: +5521 22092644

BR (RIO DE JANEIRO) participant 147˙978.00
11    ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU

 Organization address address: VIA FIORENTINA 151
city: SIENA
postcode: 53100

contact info
Titolo: Dr.
Nome: Cristiana
Cognome: Tozzi
Email: send email
Telefono: 390578000000
Fax: 390578000000

IT (SIENA) participant 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

vitro    kinases    src    leukocyte    models    drug    mice    chronic    preclinical    inflammation    members    vivo    selected    inflammatory    kinase    recently    autoimmune    functions    family    inhibitors    diseases    related   

 Obiettivo del progetto (Objective)

'The project aims to develop novel inhibitors of chronic autoimmune and inflammatory diseases by targeting members of the Src tyrosine kinase family. Src-family kinases have recently emerged as major therapeutic targets in malignant diseases but their suitability as potential targets of inflammatory diseases has not yet recieved widespread acceptance. On the other hand, members of the applicant consortium have recently obtained genetic evidence showing that myeloid Src-family kinases (Hck, Fgr and Lyn) are indispensable for murine models of autoimmune inflammatory diseases such as rheumatoid arthritis or blistering skin diseases. They also developed a number of novel Src-family kinase inhibitors that also block inflammation-related in vitro leukocyte functions. The applicants will test and further develop novel Src-family kinase inhibitors as anti-inflammatory compounds, using several in vitro and in vivo inflammation assays to optimize the structure of the selected molecules. They will also test whether Src-family inhibitors already in clinical use in oncology patients also inhibit inflammatory processes. Finally, they will use Src-family kinase-deficient mice in several inflammation models to test the role of those kinases in more detail and to provide further reference information for the consortium's preclinical drug development activity. The selected inhibitors and mutant mice will be pre-screened using various inflammation-related in vitro leukocyte functions and short-term in vivo inflammation models, and then analyzed in detail using a number of in vivo mouse models of chronic autoimmune and inflammatory diseases. The project is expected to result in development of novel preclinical drug candidates against chronic autoimmune and inflammatory disease with novel mechanism of action, as well as novel knowledge on the role of Src-family kinases in inflammatory diseases. The project will be performed in close cooperation between European and Brazilian scientists.'

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