OPTISTEM

Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases

 Coordinatore UNIVERSITA DEGLI STUDI DI MILANO 

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Mario
Cognome: Ferrante
Email: send email
Telefono: +3902 50314861
Fax: +3902 5031 4862

 Nazionalità Coordinatore Italy [IT]
 Sito del progetto http://www.optistem.org/
 Totale costo 16˙564˙311 €
 EC contributo 11˙992˙312 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-IP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-01-01   -   2013-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI MILANO

 Organization address address: Via Festa Del Perdono 7
city: MILANO
postcode: 20122

contact info
Titolo: Dr.
Nome: Mario
Cognome: Ferrante
Email: send email
Telefono: +3902 50314861
Fax: +3902 5031 4862

IT (MILANO) coordinator 1˙242˙584.52
2    UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

 Organization address address: VIA UNIVERSITA 4
city: MODENA
postcode: 41100

contact info
Titolo: Prof.
Nome: Sebastiano
Cognome: Calandra Buonaura
Email: send email
Telefono: +39 059 2055450
Fax: +39 059 2055671

IT (MODENA) participant 1˙659˙000.00
3    THE UNIVERSITY OF EDINBURGH

 Organization address address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL

contact info
Titolo: Ms.
Nome: Angela
Cognome: Noble
Email: send email
Telefono: +44 131 650 9024
Fax: +44 131 650 9023

UK (EDINBURGH) participant 1˙239˙452.00
4    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Nadia
Cognome: Khelef
Email: send email
Telefono: +33 1 40 61 33 78
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) participant 872˙900.00
5    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Mr.
Nome: Paul
Cognome: Labett
Email: send email
Telefono: +44 2078488184
Fax: +44 2078488187

UK (LONDON) participant 758˙974.00
6    MOLECULAR MEDICINE SPA

 Organization address address: VIA OLGETTINA 58
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Enrico
Cognome: Cappelli
Email: send email
Telefono: +38 2 21277302
Fax: +39 2 21277353

IT (MILANO) participant 758˙900.00
7    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Yann
Cognome: Barrandon
Email: send email
Telefono: +41 21 693 1633
Fax: +41 21 693 1630

CH (LAUSANNE) participant 751˙700.00
8    MILTENYI BIOTEC GMBH

 Organization address address: FRIEDRICH EBERT STRASSE 68
city: BERGISCH GLADBACH
postcode: 51429

contact info
Titolo: Dr.
Nome: Michael
Cognome: Apel
Email: send email
Telefono: +49 2204 8306 4236
Fax: +49 2204 8306 4488

DE (BERGISCH GLADBACH) participant 620˙200.00
9    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Mihaja
Cognome: Auguste
Email: send email
Telefono: +33 1 48 07 34 15
Fax: +33 1 48 07 34 32

FR (PARIS) participant 510˙500.00
10    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Dr.
Nome: Stella
Cognome: Keeble
Email: send email
Telefono: +44 1865 221315
Fax: +44 1865 768876

UK (OXFORD) participant 476˙900.00
11    DANDO WEISS & COLUCCI LIMITED

 Organization address address: LOWER BRISTOL ROAD MINERVA HOUSE
city: BATH
postcode: BA2 9ER

contact info
Titolo: Mr.
Nome: Jeffrey
Cognome: Dando
Email: send email
Telefono: 441179000000

UK (BATH) participant 471˙000.00
12    IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

 Organization address address: "Via Adamello, 16"
city: MILAN
postcode: 20139

contact info
Titolo: Ms.
Nome: Raffaela
Cognome: Zoboli
Email: send email
Telefono: +39 02 574303202
Fax: +39 02 574303231

IT (MILAN) participant 410˙900.00
13    IRCCS - ASSOCIAZIONE LA NOSTRA FAMIGLIA 'ISTITUTO SCIENTIFICO EUGENIO MEDEA'

 Organization address address: VIA DON LUIGI MONZA 1
city: PONTE LAMBRO
postcode: 22037

contact info
Titolo: Dr.
Nome: Laura
Cognome: Nulli
Email: send email
Telefono: +39 031 625111
Fax: +39 031 625

IT (PONTE LAMBRO) participant 410˙900.00
14    UNIVERSIDAD POMPEU FABRA

 Organization address address: PLACA DE LA MERCE 10-12
city: BARCELONA
postcode: 8002

contact info
Titolo: Ms.
Nome: Eva
Cognome: Martín
Email: send email
Telefono: 34935422140
Fax: 34935421440

ES (BARCELONA) participant 410˙900.00
15    Fondazione Centro San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 4845
Fax: +39 02 2643 4717

IT (Milano) participant 383˙900.00
16    HOSPICES CANTONAUX CHUV

 Organization address address: Rue du Bugnon 21
city: LAUSANNE
postcode: 1005

contact info
Titolo: Ms.
Nome: Emmanuelle
Cognome: Savioz-Dayer
Email: send email
Telefono: +41 21 314 2432
Fax: +41 21 314 2468

CH (LAUSANNE) participant 369˙200.00
17    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: +44 2031083033
Fax: +44 20 78132849

UK (LONDON) participant 324˙000.00
18    CANCER RESEARCH UK

 Organization address address: ST JOHN STREET 407 ANGEL BUILDING
city: LONDON
postcode: EC1V 4AD

contact info
Titolo: Ms.
Nome: Robina
Cognome: Ibanda
Email: send email
Telefono: +44 20 7438 5366
Fax: +44 20 7438 5451

UK (LONDON) participant 250˙001.48
19    HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH

 Organization address address: Inhoffenstrasse 7
city: BRAUNSCHWEIG
postcode: 38124

contact info
Titolo: Dr.
Nome: Michael
Cognome: Strätz
Email: send email
Telefono: +49 531 6181 2020
Fax: +49 531 6181 2299

DE (BRAUNSCHWEIG) participant 70˙400.00
20    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Titolo: Dr.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: 390226000000
Fax: 390226000000

IT (MILANO) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cells    first    corneal    tissue    ct    cell    animal    lamina    treated    facilities    therapy    pre    dmd    patients    eye    biology    transplantation    devastating    cts    epithelia    epithelial    angiogenesis    basic    trials    improvement    structural    muscle    stem    basal    surface    diseases    related    skeletal    clinical    optistem    degenerative    skin    muscular    treating    march    total    models   

 Obiettivo del progetto (Objective)

'This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and in the first clinical trials. Much remains to be done on the basic biology of stem cells to provide new tools for cell therapy trials. Also transplantation related issues, such as engraftment, angiogenesis, tissue remodeling and immune response remain to be addressed. In general, cell therapy necessitates a continuous cross-talk among biologists and clinicians as well as crossing boundaries among different tissues/diseases. Despite many structural and functional differences, epithelia and skeletal muscle share some key features such as spatially ordered cell architecture, centered on a supporting basal lamina to which stem cells are anchored. Indeed mutations in structural proteins linking the cell membrane to the basal lamina are responsible for similarly devastating diseases such as muscular dystrophies and epidermolysis bullosa. A multi-tissue approach allows jointly addressing and solving not only scientific and clinical problems but also regulatory and ethical issues related to these novel procedures. Finally, sharing high valued dedicated platforms such as large animal facilities and GMP cell culture facilities increases performance and reduces costs. Based on these considerations, a network of internationally recognized experts in muscle and epithelial cell biology, immunology, angiogenesis, and molecular pharmacology with two stem cell-based Companies has been assembled, creating a synergistic approach that will increase the chance of success for ongoing and future clinical trials with stem cells, that are integral part of this proposal.'

Introduzione (Teaser)

The objective of the OPTISTEM project is to develop new applications of stem cells for degenerative diseases. The primary focus of the project is on clinical trials (CTs) with epithelial and muscle stem cells.

Descrizione progetto (Article)

The organism makes new cells all the time. Some specialised cells, such as blood and muscle cells, are unable to make copies of themselves through cell division. Instead, they are replenished from populations of stem cells. Stem cells may also hold the key to replacing cells lost in many devastating diseases for which there are currently no cures.

'Optimisation of stem cell therapy for clinical trials of degenerative skin and muscle diseases' (OPTISTEM) is an EU-funded project investigating how stem cells could be used to treat degenerative diseases of skeletal muscle or epithelia such as skin or the surface of the eye. The project includes 18 partners from six European countries. OPTISTEM combines basic research about stem cells with pre-clinical work and CTs. The project began in March 2009 and will run for five years.

Primarily, project members aim to develop cell therapy trials for patients with muscular, skin or ocular disorders. To support and optimise CTs, large animal models are being used for in-depth investigation of the strategy. Small animal models and cell models are being employed to characterise pathways that control stem cell activity.

A preliminary validation study for children affected by Duchenne muscular dystrophy (DMD) has been completed. The CT based on transplanting mesoangioblasts (muscle stem cells) in DMD patients started in March 2011. In total, five patients have undergone the transplant and only one serious adverse event has been observed.

The first effective autologous cell therapy CT of stem cell-derived cornea transplantation has been completed, demonstrating the potential of stem cell therapeutics in treating a common disorder. Three patients with massive unilateral destruction of the corneal surface have been treated with eye stem cells from their healthy eye.

During the course of OPTISTEM a total of 10 patients with one or two blind eyes have been treated. So far, all patients treated had a substantial improvement of corneal transparency, an amelioration of the clinical signs and an improvement of visual acuity in the treated eye.

Researchers also identified a new type of muscle stem cell, novel methods to generate muscle stem cells from reprogrammed cells and new factors important for muscle formation. Results of the project were presented in more than 70 publications and are available on the http://www.OPTISTEM.org (project website) .

Stem cells have great potential for treating disease. OPTISTEM aims to find the way for new stem cell therapies through a combination of basic stem cell biology, pre-clinical work and CTs.

Altri progetti dello stesso programma (FP7-HEALTH)

PEPLASER (2009)

Combinatorial synthesis of peptide arrays with a laser printer

Read More  

PNEUMOPATH (2009)

A comprehensive dissection of pneumococcal-host interactions

Read More  

CAM-PAC (2013)

Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer

Read More