NANOTRANSKINETICS

"Modelling basis and kinetics of nanoparticle interaction with membranes, uptake into cells, and sub-cellular and inter-compartmental transport"

 Coordinatore UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: 35317161656
Fax: 35317161216

 Nazionalità Coordinatore Ireland [IE]
 Sito del progetto http://www.nanotranskinetics.eu
 Totale costo 1˙305˙596 €
 EC contributo 993˙013 €
 Programma FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies
 Code Call FP7-NMP-2010-EU-USA
 Funding Scheme CP-FP
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-11-01   -   2014-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN

 Organization address address: BELFIELD
city: DUBLIN
postcode: 4

contact info
Titolo: Mr.
Nome: Donal
Cognome: Doolan
Email: send email
Telefono: 35317161656
Fax: 35317161216

IE (DUBLIN) coordinator 392˙856.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Joachim
Cognome: Raedler
Email: send email
Telefono: +4989 2180 2437
Fax: +4989 2180 3182

DE (MUENCHEN) participant 314˙400.00
3    UNIVERSITAT DE BARCELONA

 Organization address address: GRAN VIA DE LES CORTS CATALANES 585
city: BARCELONA
postcode: 8007

contact info
Titolo: Mr.
Nome: Xavier
Cognome: Gutierrez
Email: send email
Telefono: +34 93 403 53 85
Fax: +34 93 448 94 34

ES (BARCELONA) participant 285˙757.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

corona    organisms    models    particles    predictive    mechanisms    biological    bare    protein    principles    particle    sites    cells    regulation    nanoparticles    prediction    limited    barriers    data    interactions    experimental   

 Obiettivo del progetto (Objective)

'The prediction of biological (and in particular toxicological) impacts has, as its basic pre-requisite, the correct prediction of the sites of action and localization of the nanoparticle in living organisms. We have identified the need for a paradigm shift in modelling these properties for nanoscale objects. The interactions between bare particles and organisms (cells, biological barriers) is radically different in the presence of proteins and lipids derived from the biological environment (the ‘protein corona’). The bare particle characteristic is therefore insufficient to describe the system. Similarly, nanoparticles are trafficked and translocated between sites by active biological processes where traditional ‘equilibrium’ principles for small molecules no longer apply. NanoTransKinetics is firmly based on advanced high quality experimental data on the distribution of nanoparticles in cells, across barriers, and (more limited) in vivo. We frame phenomenological models in a modular manner by abstracting the essential relevant principles of particle-protein (and matrix) interactions, cellular and barrier transport mechanisms of nanoparticles, fitting them to experimental data. More detailed models allow for explicit checking of mechanisms and movements of individual particles into cells and across barriers. Enormous amounts of experimental data are now available to validate the models. A predictive capacity requires only simple input data on particle, corona and similar characteristics. The basis of these claims has been checked in preliminary studies, and a limited number of interactions, particles fluxes (and control parameters) between prescribed sites are sufficient to specify the system at each level of description. Resources (reaching far beyond the program itself) have been mobilised in experimental work in the Partners laboratories, and EU and US collaborations. The output will be predictive tools for use in nanosafety research and regulation and beyond.'

Introduzione (Teaser)

Nanomaterials are revolutionising fields as diverse as energy and medicine. EU-funded scientists are developing mathematical models to predict their hazards, thereby guiding design and regulation to ensure human and environmental safety.

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