EU-MASCARA

Markers for Sub-Clinical Cardiovascular Risk Assessemnt

 Coordinatore  

 Organization address address: University Avenue
city: GLASGOW
postcode: G12 8QQ

contact info
Titolo: Prof.
Nome: Anna
Cognome: Dominiczak
Email: send email
Telefono: 441413000000

 Nazionalità Coordinatore Non specificata
 Sito del progetto http://www.eu-mascara.eu/index.php
 Totale costo 8˙113˙788 €
 EC contributo 5˙990˙880 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-12-01   -   2016-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW

 Organization address address: University Avenue
city: GLASGOW
postcode: G12 8QQ

contact info
Titolo: Prof.
Nome: Anna
Cognome: Dominiczak
Email: send email
Telefono: 441413000000

UK (GLASGOW) coordinator 1˙027˙608.05
2    MOSAIQUES DIAGNOSTICS GMBH

 Organization address address: Mellendorfer Strasse 7-9
city: HANNOVER
postcode: 30625

contact info
Titolo: Prof.
Nome: Harald
Cognome: Mischak
Email: send email
Telefono: 4951160000000

DE (HANNOVER) participant 788˙875.00
3    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Elke
Cognome: Lammertyn
Email: send email
Telefono: +32 16 32 06 21
Fax: +32 16 32 65 15

BE (LEUVEN) participant 539˙353.60
4    Randox Clinics Limited

 Organization address address: Diamond Road 34
city: Crumlin
postcode: BT29 4QY

contact info
Titolo: Dr.
Nome: Mark
Cognome: Piper
Email: send email
Telefono: +28 9445 2912

UK (Crumlin) participant 424˙396.00
5    ACS BIOMARKER BV

 Organization address address: OXFORDLAAN 70
city: MAASTRICHT
postcode: 6229 EV

contact info
Titolo: Mr.
Nome: Joost
Cognome: Leenders
Email: send email
Telefono: +31 20 69 71 087

NL (MAASTRICHT) participant 401˙309.60
6    "FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA"

 Organization address address: AV BLASCO IBANEZ 17
city: VALENCIA
postcode: 46010

contact info
Titolo: Prof.
Nome: Josep
Cognome: Redon
Email: send email
Telefono: 34963862894

ES (VALENCIA) participant 374˙919.20
7    CHARITE - UNIVERSITAETSMEDIZIN BERLIN

 Organization address address: Chariteplatz 1
city: BERLIN
postcode: 10117

contact info
Titolo: Ms.
Nome: Eveline
Cognome: Fräßdorf
Email: send email
Telefono: +49 30 450576024
Fax: +49 30 450576954

DE (BERLIN) participant 367˙488.60
8    MEDIZINISCHE HOCHSCHULE HANNOVER

 Organization address address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625

contact info
Titolo: Mr.
Nome: Frank
Cognome: Dittrich
Email: send email
Telefono: 495115000000

DE (HANNOVER) participant 317˙200.00
9    ISTITUTO AUXOLOGICO ITALIANO

 Organization address address: VIA LUDOVICO ARIOSTO 13
city: MILANO
postcode: 20145

contact info
Titolo: Prof.
Nome: Alberto
Cognome: Zanchetti
Email: send email
Telefono: +390261911 2237

IT (MILANO) participant 315˙632.40
10    FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA

 Organization address address: AVENIDA DE PIO XII 55
city: PAMPLONA
postcode: 31008

contact info
Titolo: Prof.
Nome: Javier
Cognome: Díez Martínez
Email: send email
Telefono: +34 948 194700

ES (PAMPLONA) participant 314˙124.25
11    Kite Innovation (Europe) Limited

 Organization address address: 3M BUCKLEY INNOVATION CENTRE BIC 2/01
city: HUDDERSFIELD
postcode: HD1 3BD

contact info
Titolo: Ms.
Nome: Eloïse
Cognome: Trabut
Email: send email
Telefono: 441484000000

UK (HUDDERSFIELD) participant 280˙365.60
12    UNIVERSITEIT MAASTRICHT

 Organization address address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD

contact info
Titolo: Dr.
Nome: Stephane
Cognome: Heymans
Email: send email
Telefono: +31 43 388 1645

NL (MAASTRICHT) participant 271˙761.50
13    EMERGENTEC BIODEVELOPMENT GMBH

 Organization address address: GERSTHOFER STRASSE 29-31
city: VIENNA
postcode: 1180

contact info
Titolo: Dr.
Nome: Bernd
Cognome: Mayer
Email: send email
Telefono: +43 1 4034966

AT (VIENNA) participant 222˙186.00
14    UNIVERSITAETSKLINIKUM AACHEN

 Organization address address: Pauwelsstrasse 30
city: AACHEN
postcode: 52074

contact info
Titolo: Mr.
Nome: Volker
Cognome: Legewie
Email: send email
Telefono: +49 241 8088494
Fax: +49 241 8082051

DE (AACHEN) participant 136˙104.32
15    UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA

 Organization address address: PIAZZA DELL'ATENEO NUOVO 1
city: MILANO
postcode: IT-20126

contact info
Titolo: Prof.
Nome: Giuseppe
Cognome: Mancia
Email: send email
Telefono: 390392000000
Fax: 39039322274

IT (MILANO) participant 118˙666.80
16    Medizinische Universitaet Graz

 Organization address address: AUENBRUGGERPLATZ 2
city: GRAZ
postcode: 8036

contact info
Titolo: Prof.
Nome: Burkert
Cognome: Pieske
Email: send email
Telefono: 4331640000000

AT (GRAZ) participant 90˙889.08

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

platform    diagnostic    risk    predicting    phenotypes    population    monitored    validate    markers    genetic    data    patient    analysed    worldwide    health    cardiovascular    function    heart    packages    clinical    mascara    hypertension    diagnosis    disease    scientists    cohorts    diseases    inflammation    predictive    cardiac    blood    samples    patients    prediction    biomarkers   

 Obiettivo del progetto (Objective)

'EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existing diagnostic and predictive algorithms. For this purpose a large number of cohorts from different European regions, both patient and population cohorts, that have been accurately assessed for cardiovascular phenotypes are readily available to the consortium. Access to clinical samples and to standardised cardiovascular phenotypes will be granted by a strong clinical platform as one of the key work packages of EU-MASCARA. Both cross-sectional and prospective analyses will be performed that will result in the development of improved risk prediction scores. The consortium is heavily supported by contributions of SMEs in key areas of the proposed research: biomarker testing, data handling and analysis, assay development and project management. EU-MASCARA is further characterised by a strong integrative approach both within and across work packages, with results from one task informing strategies of research in other tasks. With a dedicated bioinformatics and health economic platform the most robust biomarkers will be selected and analysed for their benefit in clinical practice. EU-MASCARA will rigorously validate biomarkers that have been proposed to be associated with cardiovascular disease and risk across different disease entities and also in independent general population samples. The most robust biomarkers will be implemented in novel biochip based assays for clinical use.'

Introduzione (Teaser)

Predicting cardiovascular disease could help save millions of sufferers worldwide. European scientists are working to identify and validate biomarkers that are associated with early stages of cardiovascular disease.

Descrizione progetto (Article)

Cardiovascular diseases resulting in heart attacks, heart failure and stroke are among the leading causes of death worldwide. Factors such as hypertension (i.e. increased blood pressure) and high cholesterol levels have been linked to increased cardiovascular disease risk. Although these parameters are being monitored clinically as a means of predicting cardiovascular health, precise assessment is still not possible.

In view of this, scientists on the EU-funded 'Markers for sub-clinical cardiovascular risk assessment' (http://www.eu-mascara.eu (EU-MASCARA)) project have set out to identify novel biomarkers of cardiovascular risk. These biomarkers would provide an estimate of the patient status in terms of cardiovascular health.

To this end, project partners have analysed blood and urine samples from 350 patients with and without hypertension to select small molecules with differential expression. Additionally, they have utilised metabolomics and proteomics data from another cohort of 800 patients to identify biomarkers. To validate the association of emerging biomarkers with cardiovascular phenotypes, patients are being monitored for cardiac function. Special focus is being given to renal disease as a high risk factor for cardiovascular disease.

Genetic markers and factors related to cardiac structure, function and inflammation will also be investigated for their predictive potential. The long-term goal is to identify biomarkers for risk prediction and cardiovascular disease development.

The consortium will eventually combine established and new biomarkers with different aspects of disease pathophysiology in a predictive model. This will aid in the overall integrated analysis of complex data towards the prediction of cardiovascular disease development.

The EU-MASCARA work has significant clinical implications and is estimated to improve diagnosis and risk prediction of cardiovascular disease across Europe.

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