ORCASYN

Asymmetric Organocatalytic Cascade Reactions: Applications toward the Synthesis of Complex Natural Products

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Mr.
Nome: Gill
Cognome: Wells
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 200˙371 €
 EC contributo 200˙371 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-IIF
 Funding Scheme MC-IIF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-07-09   -   2014-07-08

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Mr.
Nome: Gill
Cognome: Wells
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

UK (OXFORD) coordinator 200˙371.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cascade    reaction    asymmetric    quantities    structurally    therapeutic    organocatalytic    sufficient    michael    compounds    powerful    natural    intermediate    toward   

 Obiettivo del progetto (Objective)

'To address the current gap in the literature in defining a suitable synthetic route toward the pharmaceutically and structurally unique cytotoxic natural products, the daphniyunnines, we wish to develop the requisite methods and strategies during this fellowship. Using novel, synthetically flexible and powerful, enantioselective organocatalytic cascade reactions will facilitate our goals in this project. Specifically, we propose to develop an novel, asymmetric organocatalyst-controlled cascade Michael-Horner-Wadsworth-Emmons reaction and a subsequent gold(I)-catalysed hydroalkylation. This would establish a novel, powerful and broadly applicable organocatalytic asymmetric strategy toward this moiety. The second objective is to address our ability to access the complex natural products via a common divergent intermediate. To accomplish this, a cascade Michael-aldol condensation reaction will yield a common advanced tetracyclic intermediate which be further elaborated toward the daphniyunnine natural products and additional analogues. This will secure sufficient quantities to fully determine the therapeutic potential of these molecules. This will enable rapid entrance toward structurally intricate intermediates and would ultimately have a profound impact in the understanding of the power of organocatalytic cascade methods in organic synthesis.'

Introduzione (Teaser)

While many natural compounds exhibit biological activity with high therapeutic potential, they are present in plant sources in minute amounts. Developing pathways to synthesise these compounds is needed to produce sufficient quantities required for compound characterisation.

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