RE-LIVER

Bottom-up reconstitution of a biomimetic bioartificial liver

 Coordinatore UNIVERSITA DI PISA 

 Organization address address: Lungarno Pacinotti 43/44
city: PISA
postcode: 56126

contact info
Titolo: Dr.
Nome: Immacolata
Cognome: Viva
Email: send email
Telefono: +39 050 2217833
Fax: +39 050 2217051

 Nazionalità Coordinatore Italy [IT]
 Totale costo 5˙377˙150 €
 EC contributo 4˙234˙877 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-2
 Funding Scheme CP-FP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-07-01   -   2015-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITA DI PISA

 Organization address address: Lungarno Pacinotti 43/44
city: PISA
postcode: 56126

contact info
Titolo: Dr.
Nome: Immacolata
Cognome: Viva
Email: send email
Telefono: +39 050 2217833
Fax: +39 050 2217051

IT (PISA) coordinator 824˙999.00
2    MEDICYTE GMBH

 Organization address address: Im Neuenheimer Feld 581
city: Heidelberg
postcode: 69120

contact info
Titolo: Mr.
Nome: Stefan
Cognome: Holder
Email: send email
Telefono: 4962220000000
Fax: 4962220000000

DE (Heidelberg) participant 1˙738˙180.00
3    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Dr.
Nome: Katherine
Cognome: Boylan
Email: send email
Telefono: +44 161 2758796
Fax: +44 161 2752445

UK (MANCHESTER) participant 763˙152.00
4    THE ELECTROSPINNING COMPANY LTD

 Organization address address: WATERMARK WAY 10
city: HERTFORD
postcode: SG13 7TZ

contact info
Titolo: Ms.
Nome: Ann
Cognome: Kramer
Email: send email
Telefono: +44 845 2693495

UK (HERTFORD) participant 559˙356.00
5    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O

 Organization address address: Oskar-von-Miller-Ring 29
city: MUENCHEN
postcode: 80333

contact info
Titolo: Ms.
Nome: Birgit
Cognome: Fuchs
Email: send email
Telefono: +49 89 28810414
Fax: +49 89 28810420

DE (MUENCHEN) participant 349˙190.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

transplant    vivo    ex    liver    metabolism    disorders    bioartificial    reproducible    organ    vitro    metabolic    function    human    livers    animal    hepatic    tissue    solid   

 Obiettivo del progetto (Objective)

'The liver, by way of its central role in both endogenous and exogenous metabolism, is one of the most well-studied organs in the human body. Hepatic tissue and its derivatives have a wide range of in-vivo and in-vitro applications from whole organ or partial lobe transplant, bioartificial ex-vivo devices, treatment of metabolic disorders to toxicology, drug metabolism and tissue regeneration. On the one hand, suitable donor livers for solid organ transplant are in short supply, while chronic liver diseases are on the increase both in Europe and world-wide. On the other hand, in-vitro and ex-vivo technologies for recapitulating liver function still fall short of reliability, consistency and predictivity, precluding many commercial applications. There is a dire need for innovative and reproducible methods for developing functional bioartificial livers or portions of liver which can be easily transplanted or reliably integrated into extracorporeal devices, essential for treating acute liver failure and other metabolic liver disorders. To avoid the risks and complications associated with animal/human matrices, yet furnish a reliable and reproducible 3D microarchitecture capable of maintaining the detoxification and metabolic functions of healthy human liver, our aim is to fabricate a novel hepatic lobuli ECM replica seeded with stable human hepatocytes and endothelial cells using the human liver as a design template through a bottom up approach. These cell-containing bioartificial constructs will be developed and characterized in vitro to assess metabolic function, protein production and angiogenic potential. They will then be implanted in animal models through minimally invasive techniques as a solid organ transplant alternative to recombinant Factor VIII-based therapy for patients with haemophilia A.'

Altri progetti dello stesso programma (FP7-HEALTH)

EUROGENTEST2 (2011)

"Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services"

Read More  

DIAGMAL (2013)

Translation of the direct-on-blood PCR-NALFIA system into an innovative near point-of-care diagnostic for malaria

Read More  

ISSC (2010)

An integrated surveillance system for infectious disease in rural China: generating evidence for early detection of disease epidemics in resource-poor settings

Read More