NANOMAL

Development of a handheld antimalarial drug resistance diagnostic device using nanowire technology

 Coordinatore ST GEORGE'S HOSPITAL MEDICAL SCHOOL 

 Organization address address: Cranmer Terrace
city: LONDON
postcode: SW17 0RE

contact info
Titolo: Ms.
Nome: Jane
Cognome: Boland
Email: send email
Telefono: +44 20 8266 6818

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 5˙236˙310 €
 EC contributo 3˙992˙150 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2012-INNOVATION-2
 Funding Scheme CP-FP
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-07-01   -   2015-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ST GEORGE'S HOSPITAL MEDICAL SCHOOL

 Organization address address: Cranmer Terrace
city: LONDON
postcode: SW17 0RE

contact info
Titolo: Ms.
Nome: Jane
Cognome: Boland
Email: send email
Telefono: +44 20 8266 6818

UK (LONDON) coordinator 994˙655.00
2    QuantuMDx Group Limited

 Organization address address: Hartley Way 9
city: Surrey
postcode: CR8 4EJ

contact info
Titolo: Mrs.
Nome: Elaine
Cognome: Warburton
Email: send email
Telefono: +44 7 912206106
Fax: +44 8 708030999

UK (Surrey) participant 2˙629˙416.00
3    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Dr.
Nome: Miles
Cognome: Davies
Email: send email
Telefono: 46852486593

SE (STOCKHOLM) participant 195˙879.00
4    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Dr.
Nome: Carsten
Cognome: Köhler
Email: send email
Telefono: +49 7 0712982366
Fax: +49 7 071294684

DE (TUEBINGEN) participant 172˙200.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

mutations    elimination    antimalarials    parasites    treatment    antimalarial    resistance    global    health    drug    patients    assessing    malarial    care    device    individual    made    malaria    point   

 Obiettivo del progetto (Objective)

'Malaria is a global health priority that has been targeted for elimination in recent years. Attaining the goals that define elimination of malaria in different countries depends critically on provision of effective antimalarials and further that these antimalarials are used appropriately in individual patients. Drug resistance is a major threat to malaria control and has important global public health implications. Over the past decades the genetic bases for resistance to most of the antimalarial classes currently in use has become defined. For some drugs and combinations, these mutations are the most important predictors of treatment failure. This proposal will innovate new technologies to confirm malaria diagnosis and detect drug resistance in malaria parasites by analysis of mutations in nucleic acids, using nanowire technology, and will result in the development of a simple, rapid and affordable point-of-care handheld diagnostic device. The device will be useful at many levels in malarial control by:

1. Optimising individual treatments for patients 2. Assessing the epidemiology of drug resistance in malaria endemic areas 3. Assessing population impacts of antimalarial interventions

The development programme capitalises on highly original and proprietary advances made by QuantuMDx in the field of point-of-care diagnostics. This is complemented by academic expertise that has made major contributions to the understanding of antimalarial drug resistance mechanisms in laboratory models, as well as parasites obtained directly from patients. The impact of this proposal can be extended rapidly to other established and emerging infectious diseases.'

Introduzione (Teaser)

Drug resistance is one of the most important factors in malaria treatment failure, often with deadly consequences. A pioneering cell phone-type device that analyses infection and malarial mutations with a finger prick could save billions of lives.

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