HELIX

The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe

 Coordinatore FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL 

 Organization address address: Calle Doctor Aiguader 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Dr.
Nome: Diana
Cognome: Van Gent
Email: send email
Telefono: +34 932147354
Fax: +34 932147301

 Nazionalità Coordinatore Spain [ES]
 Totale costo 11˙293˙215 €
 EC contributo 8˙623˙939 €
 Programma FP7-ENVIRONMENT
Specific Programme "Cooperation": Environment (including Climate Change)
 Code Call FP7-ENV-2012-two-stage
 Funding Scheme CP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-01-01   -   2017-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

 Organization address address: Calle Doctor Aiguader 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Dr.
Nome: Diana
Cognome: Van Gent
Email: send email
Telefono: +34 932147354
Fax: +34 932147301

ES (BARCELONA) coordinator 2˙306˙569.00
2    NASJONALT FOLKEHELSEINSTITUTT

 Organization address address: Lovisenberggata 8
city: OSLO
postcode: 403

contact info
Titolo: Dr.
Nome: Cahtrine
Cognome: Thomsen
Email: send email
Telefono: 4721076546

NO (OSLO) participant 2˙025˙815.00
3    FUNDACIO CENTRE DE REGULACIO GENOMICA

 Organization address address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003

contact info
Titolo: Dr.
Nome: Xavier
Cognome: Estivill
Email: send email
Telefono: 34933160138

ES (BARCELONA) participant 904˙847.00
4    IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

 Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ

contact info
Titolo: Ms.
Nome: Tatjana
Cognome: Palalic
Email: send email
Telefono: +44 207 594 6265
Fax: +44 207 594 6265

UK (LONDON) participant 772˙368.00
5    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Evelyne
Cognome: Bertino
Email: send email
Telefono: +33 4 72 13 88 58
Fax: +33 4 72 13 88 01

FR (PARIS) participant 677˙604.00
6    BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST

 Organization address address: Duckworth Lane
city: Bradford
postcode: BD9 6RJ

contact info
Titolo: Mr.
Nome: John
Cognome: French
Email: send email
Telefono: +44 1274 364403
Fax: +44 1274 364857

UK (Bradford) participant 452˙681.00
7    PANEPISTIMIO KRITIS

 Organization address address: UNIVERSITY CAMPUS GALLOS
city: RETHIMNO
postcode: 74100

contact info
Titolo: Ms.
Nome: Eleni
Cognome: Karkanaki
Email: send email
Telefono: 302810000000
Fax: 302810000000

EL (RETHIMNO) participant 402˙622.00
8    VYTAUTO DIDZIOJO UNIVERSITETAS

 Organization address address: K. DONELAICIO G. 58
city: KAUNAS
postcode: 44248

contact info
Titolo: Mrs.
Nome: Dangirute
Cognome: Radzeviciene
Email: send email
Telefono: +37037 327881

LT (KAUNAS) participant 342˙144.00
9    UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

 Organization address address: "PAZO DE SAN XEROME, PRAZA DO OBRADOIRO S/N"
city: SANTIAGO DE COMPOSTELA
postcode: 15782

contact info
Nome: Martin
Cognome: Cacheiro
Email: send email
Telefono: +34 881 816 233
Fax: +34 881 816 263

ES (SANTIAGO DE COMPOSTELA) participant 326˙227.00
10    INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS

 Organization address address: Parc Technologique Alata
city: VERNEUIL EN HALATTE
postcode: 60550

contact info
Titolo: Mrs.
Nome: Lydia
Cognome: Boutigny
Email: send email
Telefono: +33 3 44 61 81 20

FR (VERNEUIL EN HALATTE) participant 163˙710.00
11    HULPVERLENING GELDERLAND MIDDEN

 Organization address address: EUSEBIUSBUITENSINGEL 43
city: ARNHEM
postcode: 6802 EJ

contact info
Titolo: Mr.
Nome: Jeroen
Cognome: Smit
Email: send email
Telefono: 31883555017

NL (ARNHEM) participant 148˙440.00
12    SENSING & CONTROL SYSTEMS SL

 Organization address address: AVENIDA PAISOS CATALANS 71 BAIXOS
city: IGUALADA
postcode: 8700

contact info
Titolo: Mr.
Nome: Alberto
Cognome: Fernandez
Email: send email
Telefono: 34931763520

ES (IGUALADA) participant 63˙600.00
13    HYLOBATES CONSULTING S.R.L.

 Organization address address: VIA DEI MONFORTANI 57/B
city: ROMA
postcode: 100

contact info
Titolo: Mrs.
Nome: Francesca
Cognome: Bucchini
Email: send email
Telefono: +39 0698939628
Fax: +39 06 98939630

IT (ROMA) participant 37˙312.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

multiple    risk    birth    exposures    diseases    physical    environmental    data    assessments    individual    hazards    environment    neurodevelopment    integrate    tools    life    estimates    strategies    omics    habits    longitudinal    respiratory    susceptibility    cohorts    human    helix    exposure    prospective    estimate    variability    cohort    predict    disease    preventative    water    realistic    combined    obtain    food    air    child    obesity    pollutants    periods    exposome    burden    chemical    molecular    statistical    health    impact    link   

 Obiettivo del progetto (Objective)

'The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an “Early-Life Exposome” approach.

HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.

HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.'

Introduzione (Teaser)

Due to our ever changing environment and habits, exposure to environmental contaminants is growing increasingly complex, but the health impact of environmental hazards remains poorly characterized. Prospective studies focusing on periods of high susceptibility, such as early life, should help predict individual disease risks related to the environment.

Descrizione progetto (Article)

Major environmental hazards may lead to serious, chronic pathologies with large societal and economic costs, especially when exposure takes place during pregnancy or early life. Pollutants in food, water and air may be linked to a number of diseases such as neurological, respiratory, and cardiovascular disorders. To address this susceptibility through appropriate preventative measures and legislation, comprehensive data on exposure is required. In addition, we need to evaluate the combinatorial impact on health of exposure to multiple hazards.

The term exposome is used to describe the totality of exposure to environmental hazards from conception onwards. The EU-funded http://www.projecthelix.eu/ (HELIX) initiative will use prospective birth cohort studies at different sites across Europe to obtain the comprehensive, longitudinal human data needed to build on this concept.

Through specially developed tools and methods, the HELIX consortium will obtain estimates on the health impact of chemical and physical exposures in food, consumer products, water, air and the outdoor environment (external exposome). They will link these environmental exposures with alterations in the levels of metabolites, proteins, RNA transcripts and DNA methylation (internal exposome). This molecular signature will be measured by omics analyses in the cohorts.

Using novel statistical approaches, researchers will also try to associate multiple and combined environmental exposures with child health, focusing on overall growth, obesity, neurodevelopment and respiratory and allergic diseases. Importantly, HELIX will address the determinants (e.g. diet, social factors, and commuting habits) of individual variability in early-life exposures, in order to better predict individual disease risk and direct preventions.

Overall, HELIX will provide a better understanding of the effect of multiple environmental exposures early on during development. Since most studies thus far have concentrated on single pollutants, the integrated exposure concept is a more realistic approach to estimating the joint impact of the environment on health. This will lead to improved risk assessments and preventative strategies.

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