HYDROZONES
Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration
| Coordinatore | UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Organization address
address: JOSEF-SCHNEIDER-STRASSE 2 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Sito del progetto | http://www.hydrozones.eu/ |
| Totale costo | 13˙195˙256 € |
| EC contributo | 9˙749˙700 € |
| Programma | FP7-NMP
Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies |
| Code Call | FP7-NMP-2012-LARGE-6 |
| Funding Scheme | CP-IP |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-01-01 - 2017-12-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Organization address
address: JOSEF-SCHNEIDER-STRASSE 2 contact info |
DE (WUERZBURG) | coordinator | 2˙424˙073.20 |
| 2 |
UNIVERSITEIT UTRECHT
Organization address
address: Heidelberglaan 8 contact info |
NL (UTRECHT) | participant | 1˙142˙998.00 |
| 3 |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address
address: HEIDELBERGLAAN 100 contact info |
NL (UTRECHT) | participant | 834˙358.00 |
| 4 |
UNIVERSIDAD DE NAVARRA
Organization address
address: CAMPUS UNIVERSITARIO EDIFICIO CENTRAL contact info |
ES (PAMPLONA) | participant | 818˙166.00 |
| 5 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 790˙591.00 |
| 6 |
LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV
Organization address
address: HOHE STRASSE 6 contact info |
DE (DRESDEN) | participant | 551˙012.00 |
| 7 |
POLYVATION BV
Organization address
address: KADIJK 7D contact info |
NL (GRONINGEN) | participant | 498˙851.00 |
| 8 |
CELLCOTEC BV
Organization address
address: PROFESSOR BRONKHORSTLAAN 10D contact info |
NL (BILTHOVEN) | participant | 497˙506.00 |
| 9 |
LIFETEC GROUP BV
Organization address
address: DEN DOLECH GEM 3 116 2 contact info |
NL (EINDHOVEN) | participant | 479˙040.00 |
| 10 |
GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O
Organization address
address: Oskar-von-Miller-Ring 29 contact info |
DE (MUENCHEN) | participant | 458˙564.00 |
| 11 |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address
address: University Offices, Wellington Square contact info |
UK (OXFORD) | participant | 458˙254.00 |
| 12 |
MICHAEL HUBERT BARFUSS
Organization address
address: SCHWESTER ZITA WEG 11 contact info |
DE (AACHEN) | participant | 298˙176.00 |
| 13 |
INSTITUTO POLITECNICO DE LEIRIA
Organization address
address: Rua General Norton de Matos contact info |
PT (Leiria) | participant | 200˙944.80 |
| 14 |
JULIUS-MAXIMILIANS UNIVERSITAET WUERZBURG
Organization address
address: SANDERRING 2 contact info |
DE (WUERZBURG) | participant | 180˙000.00 |
| 15 |
STICHTING PROTOSPACE
Organization address
address: NIJVERHEIDSWEG 16 contact info |
NL (UTRECHT) | participant | 117˙166.00 |
| 16 |
QUEENSLAND UNIVERSITY OF TECHNOLOGY - QLD QUT
Organization address
address: GEORGE STREET 2 contact info |
AU (BRISBANE) | participant | 0.00 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Degeneration of cartilage is a major cause of chronic pain, lost mobility and reduced quality of life for millions of European citizens. From a clinical point of view treatment to achieve cartilage regeneration (hyaline) and not only repair (fibrous) remains a great challenge. No clinical therapy is available that leads to healing of cartilage defects. Current cartilage implants cannot establish the hierarchical tissue organisation that appears critical for normal cartilage function. We hypothesise that a biomimetic zonal organisation is critical for implants to achieve cartilage regeneration. HydroZONES represents an interdisciplinary consortium that adopts a strategy to regenerate, rather than repair, articular cartilage based on the tissues zonal structure and function. HydroZONES will use advanced bioprinting technology for fabrication of 3D biofunctional hydrogel constructs, eventually mechanically reinforced by degradable polymer scaffolds, as biomimetic reconstitution of the zonal organisation of natural cartilage. Constructs will be optimized for cell-free application and also for combination with chrondrogenic cells (chondrocytes and/or MSC). Stringent in vitro and long term in vivo testing of the constructs will be employed that will yield a new clinical standard for pre-clinical testing. Cutting edge 3D tissue models and bioreactor technology will be used together with in silico modelling to develop a predictive in vitro assay and test system that will be validated against the in vivo data. Installation of a quality and regulatory affair management system, GMP production, accredited in vitro testing and involvement of clinical partners and companies with experience in clinical trials ensures that the best performing construct will be brought into an optimal position for entering clinical trials at project end. HydroZONES will thus advance the European Union as world leader in the field of joint cartilage regeneration.'