TRANSPHO

Roles of non-coding RNAs in translational regulation during root developmental adaptation to phosphate starvation

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mrs.
Nome: Véronique
Cognome: Debisschop
Email: send email
Telefono: +33 1 69823264
Fax: +33 1 69823333

 Nazionalità Coordinatore France [FR]
 Totale costo 268˙781 €
 EC contributo 268˙781 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2012-IOF
 Funding Scheme MC-IOF
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-04-15   -   2016-11-01

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mrs.
Nome: Véronique
Cognome: Debisschop
Email: send email
Telefono: +33 1 69823264
Fax: +33 1 69823333

FR (PARIS) coordinator 268˙781.10

Mappa

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

translation    developmental    genomic    translational    gene    ncrnas    ribosomes    initiation    environmental    mechanistic    pi    plants    starvation    mechanisms    mrna    spatiotemporal    cells    regulation    root    ncrna    expression   

 Obiettivo del progetto (Objective)

'The sessile lifestyle of plants requires them to adapt their growth and development to environmental variation. This implies a tight spatiotemporal regulation of gene expression to control developmental responses. Translational control, the regulation of the initiation, elongation or termination of ribosomes on an mRNA, provides cells additional mechanisms to rapidly control gene expression in a reversible manner, in response to environmental and developmental cues. It is known that non-coding RNA (ncRNA) can modify spatiotemporal gene expression patterns, and play a key role in developmental plasticity. Their role in the regulation of initiation of mRNA translation have been described in animals and hinted in plants, where mechanistic details are limited. Improving tolerance to nutrient deficiency is a major goal of agricultural research. Improvement of inorganic phosphate (Pi) starvation has been the target of classical breeding and genetic engineering. ncRNAs (i.e. miRNA399) have been shown to regulate root development during Pi starvation in roots of the model plant Arabidopsis thaliana. The three objectives of this project are to (a) analyze the role of translational control at the genomic level in response to Pi starvation using state-of-the-art methods that resolve ribosome activity to the codon level; (b) to assess the role of diverse classes of ncRNA in translational regulation in response to Pi starvation; and (c) to delve into the mechanistic role of selected ncRNAs in translational regulation during Pi starvation Towards these goals, we will isolate ribosomes specifically from root meristem cells and translation will be analyzed using genomic and bioinformatics approaches, The outcome will be identification of mechanisms of translational that control root developmental response to Pi starvation. This project will provide the postdoctoral fellow training in two groups with complementary expertise in translational control and ncRNA function in plants.'

Altri progetti dello stesso programma (FP7-PEOPLE)

ALGAENET (2012)

Renewable energy production through microalgae cultivation: Closing material cycles

Read More  

5-HT RADIOTRACERS (2011)

Development of New PET tracers for in vivo 5-HT2A and 5-HT7 Brain Imaging

Read More  

3DCELLART (2012)

Cytoskeleton architecture in host cells during Listeria infection using cryo-electron tomography

Read More