A-PARADDISE

Anti-Parasitic Drug Discovery in Epigenetics

 Coordinatore INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) 

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mrs.
Nome: Virginie
Cognome: Chameroy
Email: send email
Telefono: +33 320 29 82 89
Fax: +33 320 49 01 38

 Nazionalità Coordinatore France [FR]
 Totale costo 8˙638˙614 €
 EC contributo 5˙999˙991 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-02-01   -   2017-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Mrs.
Nome: Virginie
Cognome: Chameroy
Email: send email
Telefono: +33 320 29 82 89
Fax: +33 320 49 01 38

FR (PARIS) coordinator 755˙604.00
2    KANCERA AB

 Organization address address: BANVAKTSVAGEN 22 KAROLINSKA INSTITUTET SCIENCE PARK
city: SOLNA
postcode: 171 48

contact info
Titolo: Dr.
Nome: Martin
Cognome: Norin
Email: send email
Telefono: +46 735 20 40 02

SE (SOLNA) participant 952˙100.00
3    FUNDACAO OSWALDO CRUZ

 Organization address address: AVENIDA BRASIL 4365
city: RIO DE JANEIRO
postcode: 21040 900

contact info
Titolo: Mr.
Nome: Maurício
Cognome: Zuma
Email: send email
Telefono: +55 22092652

BR (RIO DE JANEIRO) participant 866˙520.00
4    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

 Organization address address: Rue Laurent Fries 1
city: ILLKIRCH GRAFFENSTADEN
postcode: 67404

contact info
Titolo: Dr.
Nome: Steve
Cognome: Brooks
Email: send email
Telefono: +33 3 88 65 33 94

FR (ILLKIRCH GRAFFENSTADEN) participant 440˙840.00
5    UNIVERSIDADE DE SAO PAULO

 Organization address address: RUA DA REITORIA 109 BUTANTA
city: SAO PAULO SP
postcode: 05508 900

contact info
Titolo: Mr.
Nome: Kem
Cognome: Yoshida
Email: send email
Telefono: +55 11 3035 0550

BR (SAO PAULO SP) participant 411˙665.00
6    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

 Organization address address: FAHNENBERGPLATZ
city: FREIBURG
postcode: 79085

contact info
Titolo: Prof.
Nome: Manfred
Cognome: Jung
Email: send email
Telefono: +49 7612034896

DE (FREIBURG) participant 374˙400.00
7    UNIVERSITY OF EAST ANGLIA

 Organization address address: EARLHAM ROAD
city: NORWICH
postcode: NR4 7TJ

contact info
Titolo: Mrs.
Nome: Yvonne
Cognome: Kirkham
Email: send email
Telefono: +44 1603 597197

UK (NORWICH) participant 334˙241.00
8    INSERM - TRANSFERT SA

 Organization address address: Rue Watt 7
city: PARIS
postcode: 75013

contact info
Titolo: Mr.
Nome: Louis
Cognome: Jammayrac
Email: send email
Telefono: +33 155030101

FR (PARIS) participant 313˙190.00
9    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Marie-Laure
Cognome: Rosso
Email: send email
Telefono: +33 1 44 38 95 26
Fax: +33 1 40 61 39 40

FR (PARIS CEDEX 15) participant 298˙598.00
10    UNIVERSIDADE FEDERAL DO RIO DE JANEIRO

 Organization address address: AV BRIGADEIRO TROMPOWSKI SN 2
city: RIO DE JANEIRO
postcode: 21941 590

contact info
Titolo: Prof.
Nome: Marcello
Cognome: Fantappie
Email: send email
Telefono: +55 2122708647

BR (RIO DE JANEIRO) participant 285˙474.00
11    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

 Organization address address: Piazzale Aldo Moro 5
city: ROMA
postcode: 185

contact info
Titolo: Mrs.
Nome: Cinzia
Cognome: Murdocca
Email: send email
Telefono: +39 0649913968

IT (ROMA) participant 284˙016.00
12 Nome Ente NON disponibile BR participant 268˙680.00
13    MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

 Organization address address: UNIVERSITAETSPLATZ 10
city: HALLE (Saale)
postcode: 6099

contact info
Titolo: Dr.
Nome: Sigrid
Cognome: Köhne
Email: send email
Telefono: +49 345 5521303
Fax: +49 345 5527396

DE (HALLE (Saale)) participant 229˙800.00
14    ADLEGO BIOMEDICAL AB

 Organization address address: BOX 42
city: UPPSALA
postcode: 751 03

contact info
Titolo: Mr.
Nome: Urban
Cognome: Höglund
Email: send email
Telefono: +46 733421737

SE (UPPSALA) participant 184˙863.00
15    GRIFFITH UNIVERSITY

 Organization address address: KESSELS ROAD NATHAN 170
city: BRISBANE
postcode: 4111

contact info
Titolo: Mrs.
Nome: Nicki
Cognome: Church
Email: send email
Telefono: +617 373 58029

AU (BRISBANE) participant 0.00
16    THE UNIVERSITY OF QUEENSLAND

 Organization address address: ST LUCIA
city: BRISBANE
postcode: 4072

contact info
Titolo: Mrs.
Nome: Lyn
Cognome: Fairlie
Email: send email
Telefono: +61 733462396

AU (BRISBANE) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

falciparum    mansoni    chemical    assays    screening    drug    inhibitors    phenotypic    vivo    molecular    inhibitor    compounds    enzymes    paraddise       cruzi    parasites    optimisation    hme    optimized    leishmania    selected    characterization    hmes    permit    vitro   

 Obiettivo del progetto (Objective)

'This proposal builds on the proven methodology developed in the SEtTReND FP7 project to develop inhibitors of schistosome HME as lead compounds for new drugs. We will employ a target-based strategy for the development of novel drug leads against schistosomiasis, leishmaniasis, Chagas disease and malaria by targeting histone modifying enzymes (HME), in particular those involved in acetylation/deacetylation and methylation/demethylation. The principal objectives of A-PARADDISE are: - The identification of HMEs from Leishmania sp. and Trypanosoma cruzi and the molecular characterization and functional characterization of selected potential targets, - Phenotypic screening of Leishmania, T. cruzi, S. mansoni and P. falciparum using HME class inhibitors, inhibitors developed specifically against S. mansoni and P. falciparum HMEs. This will permit us to obtain a comprehensive view of inhibitor classes and chemical scaffolds of interest, - Production of recombinant Leishmania and T. cruzi HME proteins, structural studies. Selected, validated target enzymes will be produced, crystallized and analysed by X-ray diffraction. Assays will be optimized to permit testing of inhibitors, - High-throughput and structure-based (in silico) screening of selected HMEs. Inhibitors selected will be further screened by phenotypic assays on the parasites in vitro, - Optimisation of inhibitor structures by chemical synthesis based on molecular modelling studies (inhibitors of all origins), - Transcriptomic analysis of drug-treated parasites to verify target specificity and mechanism of action (all parasites), - Pharmacological and toxicological studies (in vitro and in vivo) of selected inhibitors, in vivo testing of compounds in parasite-infected mice. The overall objective of the A-PARADDISE project is to develop optimized epigenetic inhibitors for further testing and optimisation as drug candidates against the four parasites studied.'

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