ASKLEPIOS

Advanced Studies towards Knowledge on Lyssavirus Encephalitis Pathogenesis Improving Options for Survival

 Coordinatore ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Albert
Cognome: Osterhaus
Email: send email
Telefono: +3110 7044066

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 4˙072˙356 €
 EC contributo 2˙994˙881 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-11-01   -   2016-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Prof.
Nome: Albert
Cognome: Osterhaus
Email: send email
Telefono: +3110 7044066

NL (ROTTERDAM) coordinator 706˙679.00
2    VYZKUMNY USTAV VETERINARNIHO LEKARSTVI

 Organization address address: Hudcova 70
city: BRNO
postcode: 62132

contact info
Titolo: Dr.
Nome: Daniel
Cognome: Ruzek
Email: send email
Telefono: +420 533331101
Fax: +420 541211229

CZ (BRNO) participant 482˙506.00
3    THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS

 Organization address address: Area 1A, Nobel House, Smith Square 17
city: LONDON
postcode: SW1P 3JR

contact info
Titolo: Mrs.
Nome: Clare
Cognome: French
Email: send email
Telefono: +44 1932 359547
Fax: +44 1932 357230

UK (LONDON) participant 470˙057.00
4    PANSTWOWY INSTYTUT WETERYNARYJNY - PANSTWOWY INSTYTUT BADAWCZY

 Organization address address: Partyzantow 57
city: PULAWY
postcode: 24100

contact info
Titolo: Prof.
Nome: Jan
Cognome: Zmudzinski
Email: send email
Telefono: +48 818893261

PL (PULAWY) participant 428˙299.00
5    ARTEMIS ONE HEALTH RESEARCH BV

 Organization address address: JENALAN 18C
city: UTRECHT
postcode: 3584CK

contact info
Titolo: Prof.
Nome: Eric
Cognome: Claassen
Email: send email
Telefono: +31 6 20443098

NL (UTRECHT) participant 347˙360.00
6    SZENT ISTVAN UNIVERSITY

 Organization address address: Pater Karoly utca 1
city: GODOLLO
postcode: 2100

contact info
Titolo: Dr.
Nome: Tamas
Cognome: Bakonyi
Email: send email
Telefono: +36 1 2519900
Fax: +36 1 2519260

HU (GODOLLO) participant 240˙000.00
7    MAGYAR TUDOMANYOS AKADEMIA AGRARTUDOMANYI KUTATOKOZPONT

 Organization address address: BRUNSZVIK STREET 2
city: MARTONVASAR
postcode: 2462

contact info
Titolo: Dr.
Nome: Miklós
Cognome: Gyuranecz
Email: send email
Telefono: +36 467 4060

HU (MARTONVASAR) participant 239˙940.00
8    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Dr.
Nome: Myriam
Cognome: Witvrouw
Email: send email
Telefono: +32 16320623
Fax: 3216326515

BE (LEUVEN) participant 59˙040.00
9    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Mr.
Nome: Thomas
Cognome: Wiest
Email: send email
Telefono: +33 140613378

FR (PARIS CEDEX 15) participant 21˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

il    bbb    pep    therapeutic    leads    infection    vitro    inhibit    inhibitors    molecules    efficient    pathogenesis    rabv    mechanisms    asklepios    host    brain    pursuit    rabies    rational    map    unravel   

 Obiettivo del progetto (Objective)

'The overall aim of ASKLEPIOS is to unravel and increase our understanding of the mechanisms that govern pathogenesis of rabies virus (RABV) infection, in pursuit of the rational identification of novel therapeutic leads for rabies encephalitis. Several studies have been conducted over the past decades attempting to unravel the pathogenesis of this deadly disease, however with limited success. New knowledge on the mechanisms of the RABV life-cycle and interaction with the host is needed to identifying clinically applicable therapeutic leads, in search of rational intervention strategies. The project objectives are to: 1. Identify molecules that inhibit RABV replication 2. Identify molecules that inhibit detrimental host responses to RABV infection: 3. Show whether opening the blood-brain-barrier (BBB) improves treatment efficacy: 4. Validate the potential of the molecules identified under 1 and 2 to be used as post-exposure prophylaxis (PEP) when classical PEP is ineffective. In pursuit of these objectives ASKLEPIOS will perform in vitro screening of the anti-viral effect of type-I IFNs, MAP kinase inhibitors and siRNAs. Second, the therapeutic potential of inhibiting the pyroptotic pathway and inflammatory response will be investigated by using inhibitors of caspase-1, IL-1β, TNF-α IL-6 and MAP kinases. Third, the capacity of molecules to reach the brain will be first evaluated using an efficient in vitro BBB system and in vivo mouse studies.. The most efficient molecule to open the BBB will be co-administrated with the selected therapeutic molecules in the subsequent stages of the project. The results will be collected and synthesized and tested in mice to identify the most effective approach. The ability to clear infection and recover from rabies will be evaluated for each therapeutic scheme identified'

Altri progetti dello stesso programma (FP7-HEALTH)

WINGS (2011)

"West Nile Integrated Shield Project: Epidemiology, Diagnosis and Prevention of West Nile Virus in Europe"

Read More  

REMEDI (2010)

Resolution Enhanced Microscopy for Medical Diagnostics

Read More  

NEUROBID (2010)

Neuroscience on Barriers in Development

Read More