NR-NET
Control of metabolic and inflammatory pathways by nuclear receptors
| Coordinatore | BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Organization address
address: Al. Fleming Street 34 contact info |
| Nazionalità Coordinatore | Greece [EL] |
| Totale costo | 3˙971˙184 € |
| EC contributo | 3˙971˙184 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2013-ITN |
| Funding Scheme | MC-ITN |
| Anno di inizio | 2013 |
| Periodo (anno-mese-giorno) | 2013-09-01 - 2017-08-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Organization address
address: Al. Fleming Street 34 contact info |
EL (VARI-ATHENS) | coordinator | 757˙301.02 |
| 2 |
UNIVERSITE DE LAUSANNE
Organization address
city: LAUSANNE contact info |
CH (LAUSANNE) | participant | 540˙631.52 |
| 3 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 504˙297.20 |
| 4 |
UNIVERSITY OF LEICESTER
Organization address
address: University Road contact info |
UK (LEICESTER) | participant | 481˙694.40 |
| 5 |
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Organization address
address: Piazza Umberto I 1 contact info |
IT (BARI) | participant | 407˙996.60 |
| 6 |
DEBRECENI EGYETEM
Organization address
address: EGYETEM TER 1 contact info |
HU (DEBRECEN) | participant | 390˙193.76 |
| 7 |
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
Organization address
address: Rue Laurent Fries 1 contact info |
FR (ILLKIRCH GRAFFENSTADEN) | participant | 262˙548.66 |
| 8 |
UNIVERSITA DEGLI STUDI DI MILANO
Organization address
address: Via Festa Del Perdono 7 contact info |
IT (MILANO) | participant | 247˙437.96 |
| 9 |
DIAGENODE
Organization address
address: RUE DU BOIS SAINT JEAN 3 LIEGE PARK SCIENCE contact info |
BE (SERAING) | participant | 205˙260.00 |
| 10 |
UD-GENOMED MEDICAL GENOMIC TECHNOLOGIES KUTATAS-FEJLESZTESI ES SZOLGALTATO KFT
Organization address
address: NAGYERDEI KRT 98 contact info |
HU (DEBRECEN) | participant | 173˙822.88 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'NR-NET is a multidisciplinary consortium, whose activities are directed towards the understanding of the role of Nuclear Receptors (NRs) and coregulators in metaflammatory disease. Metaflammation - metabolic disorders linked to chronic inflammation – is an emerging concept explaining the pathogenesis of a wide-spectrum of diseases. Since several nuclear receptors can directly sense metabolic alterations, we propose that they could be considered as important endogenous modulators of metaflammatory pathways further expanding the repertoire of diseases that can be intervened by NR-modulating drugs. NR-NET is expected to deliver important new knowledge on the basic biological processes involved in the mechanism of epigenetic control of gene expression by nuclear receptors, on structural and functional aspects of nuclear receptor action with an ultimate goal of better understanding the pathogenesis of metabolic disorders and inflammation. The composition of the network was designed to contain a balanced mix of labs with experience and skills in academic and industry based research, so that it can provide young researchers the opportunity to acquire skills and expertise in: a. Structural and functional aspects of NR-regulated gene expression b. Genomics and proteomics approaches to analyze complex regulatory networks c. Systems biology approaches and bioinformatics tools to define composite regulatory modules d. Studying metabolic and inflammatory pathways in model organisms The research will be conducted under the framework of a structured training program, which includes a myriad of Individual and Network-wide training activities. Apart from training in academic and industry-based research projects, specific emphasis will be given to training in transferable skills and the stimulation of creativity and entrepreneurial mindset of researchers.'