OPTIMEX

Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure

 Coordinatore NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU 

 Organization address address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491

contact info
Titolo: Prof.
Nome: Ulrik
Cognome: Wisløff
Email: send email
Telefono: +47 95883501

 Nazionalità Coordinatore Norway [NO]
 Sito del progetto http://www.ntnu.edu/optimex
 Totale costo 3˙853˙084 €
 EC contributo 2˙999˙995 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-10-01   -   2017-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    NORGES TEKNISK-NATURVITENSKAPELIGEUNIVERSITET NTNU

 Organization address address: HOGSKOLERINGEN 1
city: TRONDHEIM
postcode: 7491

contact info
Titolo: Prof.
Nome: Ulrik
Cognome: Wisløff
Email: send email
Telefono: +47 95883501

NO (TRONDHEIM) coordinator 1˙087˙161.00
2    UNIVERSITAET LEIPZIG

 Organization address address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109

contact info
Titolo: Dr.
Nome: Volker
Cognome: Adams
Email: send email
Telefono: +49 3418651671

DE (LEIPZIG) participant 563˙460.00
3    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

 Organization address address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675

contact info
Titolo: Ms.
Nome: Renate
Cognome: Rädlein
Email: send email
Telefono: +49 89 4140 2842
Fax: +49 89 4140 4926

DE (MUENCHEN) participant 456˙928.00
4    UNIVERSITAIR ZIEKENHUIS ANTWERPEN

 Organization address address: WILRIJKSTRAAT 10
city: EDEGEM
postcode: 2650

contact info
Titolo: Prof.
Nome: Viviane
Cognome: Conraads
Email: send email
Telefono: +32 474900396

BE (EDEGEM) participant 392˙815.60
5    Medizinische Universitaet Graz

 Organization address address: AUENBRUGGERPLATZ 2
city: GRAZ
postcode: 8036

contact info
Titolo: Dr.
Nome: Carolin
Cognome: Auer
Email: send email
Telefono: +0043 31638572016
Fax: 4331640000000

AT (GRAZ) participant 371˙223.60
6    Vitaphone GmbH

 Organization address address: Markircher Strasse 22
city: Mannheim
postcode: 68229

contact info
Titolo: Mr.
Nome: Walter
Cognome: Schmid
Email: send email
Telefono: +49 621178918100

DE (Mannheim) participant 128˙407.50

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

intolerance    exercise    muscles    heart    skeletal    physical    clinical    dependent    cardiovascular    elderly    ageing    prevalence    hfpef    health    disease    hf   

 Obiettivo del progetto (Objective)

'More than 14 million Europeans suffer from heart failure (HF), of which more than 50 % have HF with preserved left ventricular (LV) ejection fraction (EF) (HFPEF, “diastolic heart failure”). HFPEF is the only cardiovascular disease with increasing prevalence and incidence, affecting 10-20% of the elderly and contributing substantially to hospitalizations of elderly HF patients. Currently, no medical treatment has been shown to be effective and the economic, social and personal burden of HFPEF is enormous; this disease constitutes one of the most pressing unmet clinical needs. A cardinal feature of HFPEF is exercise intolerance. The pathophysiology of exercise intolerance in HFPEF depends on multiple factors in heart, endothelium and skeletal muscles. From a pathophysiological point of view, exercise could by far outweigh any pharmacological intervention in this heterogeneous syndrome, since lifestyle dependent risk factor, physical inactivity, and physical deconditioning underlay and contribute to HFPEF. OptimEx will focus on the cardiovascular effects of exercise training as primary and secondary prevention of HFPEF. We will combine in vivo and in vitro studies in man and rats in serial experiments that will advance our understanding of fundamental cellular and molecular mechanisms underpinning dose-dependent exercise-induced changes in the heart, blood vessels and skeletal muscles. This research is aimed to tackle one of the major health problems the developed world faces with its ageing societies and increasing prevalence of the HFPEF and will support sustainable health systems in EU member states through improvements in the clinical management of a common and disabling disease. The project is therefore highly relevant to improve the health of European citizens and important to promote healthy ageing and preventing disease.'

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