MON4STRAT

"Therapeutic Beta-Lactam Monitoring for Stratified Treatment of hospital-acquired pneumonia, improved dose-dependent efficacy, decreased treatment duration, and prevention of emergence of resistance"

 Coordinatore UNIVERSITE DE LIEGE 

 Organization address city: LIEGE
postcode: 4000

contact info
Titolo: Ms.
Nome: Isabelle
Cognome: Halleux
Email: send email
Telefono: +32 43665428
Fax: +32 43665558

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 7˙861˙595 €
 EC contributo 5˙988˙941 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2014
 Periodo (anno-mese-giorno) 2014-02-01   -   2018-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIEGE

 Organization address city: LIEGE
postcode: 4000

contact info
Titolo: Ms.
Nome: Isabelle
Cognome: Halleux
Email: send email
Telefono: +32 43665428
Fax: +32 43665558

BE (LIEGE) coordinator 1˙312˙523.00
2    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Prof.
Nome: Francoise
Cognome: Vanbambeke
Email: send email
Telefono: +32 27647378

BE (LOUVAIN LA NEUVE) participant 905˙600.00
3    WOW TECHNOLOGY

 Organization address address: RUE PIEDS D'ALOUETTE 18
city: NANINNE
postcode: 5100

contact info
Titolo: Mr.
Nome: Jean
Cognome: Demarteau
Email: send email
Telefono: +32 81719740
Fax: +32 81 40 24 44

BE (NANINNE) participant 869˙407.00
4    SERVICIO MADRILENO DE SALUD

 Organization address address: PLAZA CARLOS TRIAS BERTRAN 7
city: MADRID
postcode: 28020

contact info
Titolo: Mr.
Nome: José Ignacio
Cognome: Flores Nicolás
Email: send email
Telefono: +34 913368147

ES (MADRID) participant 563˙302.00
5    UNIVERSITE LIBRE DE BRUXELLES

 Organization address address: Avenue Franklin Roosevelt 50
city: BRUXELLES
postcode: 1050

contact info
Titolo: Dr.
Nome: Christine
Cognome: Courillon
Email: send email
Telefono: +32 2 6506718
Fax: +32 2 6502321

BE (BRUXELLES) participant 406˙850.00
6    UNIVERSITY OF HOUSTON SYSTEM

 Organization address address: EZEKIEL CULLEN BUILDING 203
city: HOUSTON
postcode: 772042022

contact info
Nome: Beverly
Cognome: Rymer
Email: send email
Telefono: +1 7137435773

US (HOUSTON) participant 400˙600.00
7    INST CARDIOMETABOLISME NUTRITION ICAN

 Organization address address: BOULEVARD DE L'HOPITAL 47-83
city: PARIS
postcode: 75013

contact info
Titolo: Prof.
Nome: Jean
Cognome: Chastre
Email: send email
Telefono: +33 142163822

FR (PARIS) participant 385˙151.00
8    AEPODIA SA

 Organization address address: RUE LOUIS DE GEER 6
city: OTTIGNIES LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Dr.
Nome: Denis
Cognome: Gossen
Email: send email
Telefono: 3210392007

BE (OTTIGNIES LOUVAIN LA NEUVE) participant 371˙504.00
9    CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE

 Organization address address: AVENUE OSCAR LAMBRET 2
city: LILLE
postcode: 59037

contact info
Titolo: Dr.
Nome: Bernadette
Cognome: Lucas
Email: send email
Telefono: +33 320446959
Fax: +33 320446630

FR (LILLE) participant 315˙752.00
10    TARTU ULIKOOL

 Organization address address: ULIKOOLI 18
city: TARTU
postcode: 50090

contact info
Titolo: Prof.
Nome: Irja
Cognome: Lutsar
Email: send email
Telefono: +372 7374171
Fax: +372 7374172

EE (TARTU) participant 315˙752.00
11    SGS EXPRIMO NV

 Organization address address: GENERAAL DE WITTELAAN 19A
city: MECHELEN
postcode: 2800

contact info
Titolo: Dr.
Nome: Philippe
Cognome: Jacqmin
Email: send email
Telefono: +32 82677608
Fax: +32 82677609

BE (MECHELEN) participant 142˙500.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

levels    vap    edr    treatment    patient    bed    beta    real    time    usable    mon    blood    clinical    adverse    dose    hap    treatments    according    data    lactam    difficult    risk    efficacy    strat   

 Obiettivo del progetto (Objective)

'Stratified clinical treatment interventions meeting patient-specific efficacy (pharmacodynamics) while at the same time lowering the risk of emergence of drug resistance (EDR) and minimizing adverse effects are particularly needed in Hospital-acquired and Ventilator-Associated pneumonia [HAP/VAP] where morbidity, mortality and health care costs remain high. β-lactam antibiotics are at the cornerstone of most effective treatments of HAP/VAP, but dosage adaptations remain difficult because available models (i) focus mainly on efficacy (neglecting EDR and dose-related side effects) and (ii) are derived from population data which imperfectly fit individual patient’s needs due to large, rapid and difficult-to-predict variations of blood levels. Current methods for monitoring β-lactam blood levels are slow and require complex instruments not usable at bed-side. Yet, generating easily, rapidly and cost-effectively real data usable at the patient’s bed-side should improve outcomes of β-lactam treatments. This is what 3 out of the 11 partners of the MON4STRAT consortium have recently developed (patent pending). Thus the objective of the Project is to integrate both (i) state-of-the-art PK/PD and EDR profiles AND (ii) real-time/patient-specific free β-lactam blood levels monitored at the patient’s bed-side according to the patented assay for developing and implementing a new approach to (i) stratify the HAP/VAP patients according to their specific response, (ii) to propose immediately applicable dose adjustments during treatment and thus (iii) to improve efficacy while reducing risk of EDR or adverse effects. The MON4STRAT approach will be validated through a prospective, multicentre, randomized clinical trial with150 adults. Its applicability in paediatrics will be tested through an observational study with 70 children/neonates. Being generic in nature, MON4STRAT will be replicable to other infectious conditions.'

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