MERCURIC

A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor PF-02341066 in KRASMT and KRASWT (with aberrant c-MET) Colorectal Cancer Patients

 Coordinatore QUEEN'S UNIVERSITY BELFAST 

 Organization address address: University Road
city: BELFAST
postcode: BT7 1NN

contact info
Titolo: Mrs.
Nome: Colleen
Cognome: Spence
Email: send email
Telefono: +44 2890975183
Fax: +44 2890975182

 Nazionalità Coordinatore United Kingdom [UK]
 Sito del progetto http://mercuric.eu/
 Totale costo 8˙096˙788 €
 EC contributo 5˙999˙994 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2013-INNOVATION-1
 Funding Scheme CP-FP
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-12-01   -   2020-11-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    QUEEN'S UNIVERSITY BELFAST

 Organization address address: University Road
city: BELFAST
postcode: BT7 1NN

contact info
Titolo: Mrs.
Nome: Colleen
Cognome: Spence
Email: send email
Telefono: +44 2890975183
Fax: +44 2890975182

UK (BELFAST) coordinator 415˙289.88
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Dr.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 1865 289800
Fax: +44 1865 289801

UK (OXFORD) participant 1˙486˙544.38
3    UNIVERSITA DEGLI STUDI DI TORINO

 Organization address address: Via Giuseppe Verdi 8
city: TORINO
postcode: 10124

contact info
Titolo: Prof.
Nome: Alberto
Cognome: Bardelli
Email: send email
Telefono: +39 0119933235
Fax: +39 0119933225

IT (TORINO) participant 711˙319.00
4    ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

 Organization address address: 3 Avenue Victoria
city: PARIS
postcode: 75004

contact info
Titolo: Ms.
Nome: Alix
Cognome: Pillot
Email: send email
Telefono: 33140274613

FR (PARIS) participant 659˙994.44
5    BELFAST HEALTH AND SOCIAL CARE TRUST

 Organization address address: "Saintfield Road, Knockbracken Healthcare Park"
city: BELFAST
postcode: BT8 8BH

contact info
Titolo: Ms.
Nome: Kate
Cognome: O'brien
Email: send email
Telefono: 44289056590

UK (BELFAST) participant 433˙308.82
6    FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON

 Organization address city: Barcelona
postcode: 8035

contact info
Titolo: Mr.
Nome: Andrés
Cognome: De Kelety Alcaide
Email: send email
Telefono: 34934893021
Fax: +0034 93 2746059

ES (Barcelona) participant 431˙625.22
7    UNIVERSITAIR ZIEKENHUIS ANTWERPEN

 Organization address address: WILRIJKSTRAAT 10
city: EDEGEM
postcode: 2650

contact info
Titolo: Prof.
Nome: Marc
Cognome: Peeters
Email: send email
Telefono: +323 8214121
Fax: +323 8213954

BE (EDEGEM) participant 430˙946.28
8    ROYAL COLLEGE OF SURGEONS IN IRELAND

 Organization address address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2

contact info
Titolo: Dr.
Nome: Bryan
Cognome: Hennessy
Email: send email
Telefono: 35318093826

IE (DUBLIN) participant 330˙183.09
9    VELINDRE NATIONAL HEALTH SERVICE TRUST

 Organization address address: Parc Nantgarw-Charnwood Court 2
city: CARDIFF
postcode: CF15 7QZ

contact info
Titolo: Dr.
Nome: Richard
Cognome: Adams
Email: send email
Telefono: +44 2920316206

UK (CARDIFF) participant 330˙183.09
10    UNIVERSITE PARIS DESCARTES

 Organization address address: Rue de l'Ecole de Medecine 12
city: PARIS
postcode: 75270

contact info
Titolo: Ms.
Nome: Rosaly
Cognome: Datchi
Email: send email
Telefono: +33 176532033
Fax: +33 176531789

FR (PARIS) participant 210˙200.00
11    Masarykova univerzita

 Organization address address: Zerotinovo namesti 9
city: BRNO STRED
postcode: 60177

contact info
Titolo: Mrs.
Nome: Katarína
Cognome: Hanušová
Email: send email
Telefono: +420 549496890

CZ (BRNO STRED) participant 200˙595.00
12    MULTIPLICOM NV

 Organization address address: GALILEILAAN 18
city: NIEL
postcode: 2845

contact info
Titolo: Prof.
Nome: Jurgen
Cognome: Del-Favero
Email: send email
Telefono: +0032 3 289 14 04

BE (NIEL) participant 193˙880.20
13    PINTAIL LTD

 Organization address address: SPRINGHILL AVENUE 77
city: BLACKROCK

contact info
Titolo: Mr.
Nome: Ciaran
Cognome: Clissmann
Email: send email
Telefono: +353 12899529

IE (BLACKROCK) participant 165˙925.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

biology    survival    met    patients    crc    inhibitor    cancer    treatment    clinical    strategy    treatments    disease    kras    benefit    subgroups   

 Obiettivo del progetto (Objective)

'Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omics”-based approaches, has revealed that cancer must be considered a heterogeneous disease. Historically, “one-size-fits-all” approaches have been standard practice in CRC treatment, but with the increased understanding of the molecular/genetic heterogeneity of CRC, it is clear that novel treatments must be developed and tested in selected subgroups to maximize the benefit of these new developments. MErCuRIC is a multicentre phase Ib/II clinical trial which will assess a novel therapeutic strategy (combined treatment of a MEK inhibitor PD-0325901 with a MET inhibitor PF-02341066) to combat metastasis, improve survival and change current clinical practice for CRC patients with KRAS mutant (MT) and KRAS wild type (WT) (with aberrant c-MET) tumours. The consortium will go beyond the current state-of-the-art by (i) employing a novel treatment strategy targeting the biology of the disease and by (ii) using next generation sequencing (NGS) and ‘xenopatients’ to identify CRC patient subgroups who will maximally benefit from this novel treatment strategy.'

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