GLYCOHIT

Glycomics by High-throughput Integrated Technologies

 Coordinatore NATIONAL UNIVERSITY OF IRELAND, GALWAY 

 Organization address address: University Road -
city: GALWAY

contact info
Titolo: Prof.
Nome: Lokesh
Cognome: Joshi
Email: send email
Telefono: +353 91 495768
Fax: +353 91 495768

 Nazionalità Coordinatore Ireland [IE]
 Sito del progetto http://glycohit.eu/
 Totale costo 4˙874˙903 €
 EC contributo 2˙993˙056 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2010-single-stage
 Funding Scheme CP-FP-SICA
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-01-01   -   2014-06-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND, GALWAY

 Organization address address: University Road -
city: GALWAY

contact info
Titolo: Prof.
Nome: Lokesh
Cognome: Joshi
Email: send email
Telefono: +353 91 495768
Fax: +353 91 495768

IE (GALWAY) coordinator 830˙455.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Hans-Joachim
Cognome: Gabius
Email: send email
Telefono: 498922000000
Fax: 498922000000

DE (MUENCHEN) participant 336˙640.00
3    National Institute for Bioprocessing Research and Training Ltd

 Organization address address: "Engineering Building, Belfield 125"
city: Dublin
postcode: 4

contact info
Titolo: Prof.
Nome: Pauline
Cognome: Rudd
Email: send email
Telefono: +353 1 7166725
Fax: +353 1 7166950

IE (Dublin) participant 274˙654.00
4    AGILENT TECHNOLOGIES ISRAEL LTD

 Organization address address: EM HAMOSHAVOT ROAD 94
city: PETACH TIKVA
postcode: 49527

contact info
Titolo: Dr.
Nome: Zohat
Cognome: Yakhini
Email: send email
Telefono: +972 3 92 88 575
Fax: +972 3 92 88 575

IL (PETACH TIKVA) participant 241˙120.00
5    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Titolo: Mr.
Nome: Eusebio
Cognome: Jimenez Arroyo
Email: send email
Telefono: +34 91 566 8852
Fax: +34 91 566 8913

ES (MADRID) participant 227˙513.00
6    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Dr.
Nome: Janne
Cognome: Lethio
Email: send email
Telefono: +46 8 51776391
Fax: +46 8 51776099

SE (STOCKHOLM) participant 213˙036.00
7    INSTITUT PASTEUR

 Organization address address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724

contact info
Titolo: Dr.
Nome: Benno
Cognome: Schwikowski
Email: send email
Telefono: +33 1 45688620
Fax: +33 1 40613704

FR (PARIS CEDEX 15) participant 186˙230.40
8    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: +49 6221 567086
Fax: +49 6221 565460

DE (HEIDELBERG) participant 158˙000.00
9    PINTAIL LTD

 Organization address address: SPRINGHILL AVENUE 77
city: BLACKROCK

contact info
Titolo: Mr.
Nome: Ciaran
Cognome: Clissmann
Email: send email
Telefono: +353 1 2899529
Fax: +353 1 2899529

IE (BLACKROCK) participant 127˙236.00
10    OSLO UNIVERSITETSSYKEHUS HF

 Organization address address: FORSKNINGSVEIEN 2B
city: OSLO
postcode: 373

contact info
Titolo: Prof.
Nome: Anne-Lise
Cognome: Børresen-Dale
Email: send email
Telefono: +47 22 78 13 73
Fax: +47 22 78 13 95

NO (OSLO) participant 90˙600.00
11    UNIVERSITE DE MONS

 Organization address address: PLACE DU PARC 20
city: MONS
postcode: 7000

contact info
Titolo: Prof.
Nome: Sven
Cognome: Saussez
Email: send email
Telefono: +32 485 716053
Fax: +32 2 3435875

BE (MONS) participant 84˙400.00
12    HUNAN UNIVERSITY

 Organization address address: LUSHAN SOUTH ROAD 1
city: CHANGSHA
postcode: 410082

contact info
Titolo: Prof.
Nome: Jian-Hui
Cognome: Jiang
Email: send email
Telefono: +86 731 88821916
Fax: +86 731 88821916

CN (CHANGSHA) participant 82˙800.00
13    TSINGHUA UNIVERSITY

 Organization address address: QING HUA YUAN
city: BEIJING
postcode: 100084

contact info
Titolo: Dr.
Nome: Jun
Cognome: Ma
Email: send email
Telefono: +86 10 62795290
Fax: +86 1062795290

CN (BEIJING) participant 82˙800.00
14    BRISTOL-MYERS SQUIBB COMPANY CORP

 Organization address address: Park Avenue 345
city: New York
postcode: 10154

contact info
Titolo: Dr.
Nome: Kirk
Cognome: Leister
Email: send email
Telefono: +1 315 432 2248
Fax: +1 315 432 4827

US (New York) participant 57˙572.00
15    KOKURITSU DAIGAKU HOJIN HOKKAIDO DAIGAKU

 Organization address address: KITA 8 NISHI 5 KITA KU
city: SAPPORO
postcode: 060 0808

contact info
Titolo: Prof.
Nome: Shin-Ichiro
Cognome: Nishimura
Email: send email
Telefono: +81 11706 9043
Fax: +81 11706 9042

JP (SAPPORO) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

technologies    rapid    htp    science    libraries    serum    exploited    glycobiomarkers    discovery    mimics    samples    clinical    glycoanalytical    lectin    array    cancer    innovative    throughput   

 Obiettivo del progetto (Objective)

'Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innovative, rapid, and high-throughput (HTP) technologies that will translate the discovery of cancer-associated glycobiomarkers from basic science to clinical application. The GlycoHIT consortium brings a highly experienced, innovative and interdisciplinary team of researchers from Europe, China and USA representing academia, industry and clinical fields to significantly enhance some of the existing glycoanalytical technologies and to advance novel HTP glycoanalytical technologies beyond current state of the art.

▪ Microchip technology and novel partitioning methods will be exploited for nanoscale HTP separations of serum glycoproteins for analysis by HPLC or LC–MS. ▪ In parallel, lectin array technology will be radically improved by the innovative use of recombinant human lectins and lectin mimics derived by screening large phage displayed combinatorial libraries. ▪ Aptamer libraries will be exploited for identification of lectin mimics and development of a glycosignature platform ▪ Compatibility of the lectin/lectin mimic array technologies with novel label-free biosensors will be explored.

Newly-developed technologies will be validated by analysis of serum samples from a variety of cancer patient cohorts and will be supported throughout by experimental interaction analysis, complex structural modelling and informatics.

Effective project management, commercially-aware intellectual property management and targeted dissemination activities supplement the core science and ensure maximum impact for the project.'

Introduzione (Teaser)

Proteins with sugar linkages are important biomarkers of cancer. Scientists are developing novel technology for rapid and high-throughput (HTP) analysis of clinical blood samples leading to early detection and improved prognosis.

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