GLYCOHIT
Glycomics by High-throughput Integrated Technologies
| Coordinatore | NATIONAL UNIVERSITY OF IRELAND, GALWAY
Organization address
address: University Road - contact info |
| Nazionalità Coordinatore | Ireland [IE] |
| Sito del progetto | http://glycohit.eu/ |
| Totale costo | 4˙874˙903 € |
| EC contributo | 2˙993˙056 € |
| Programma | FP7-HEALTH
Specific Programme "Cooperation": Health |
| Code Call | FP7-HEALTH-2010-single-stage |
| Funding Scheme | CP-FP-SICA |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-01-01 - 2014-06-30 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
NATIONAL UNIVERSITY OF IRELAND, GALWAY
Organization address
address: University Road - contact info |
IE (GALWAY) | coordinator | 830˙455.00 |
| 2 |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address
address: GESCHWISTER SCHOLL PLATZ 1 contact info |
DE (MUENCHEN) | participant | 336˙640.00 |
| 3 |
National Institute for Bioprocessing Research and Training Ltd
Organization address
address: "Engineering Building, Belfield 125" contact info |
IE (Dublin) | participant | 274˙654.00 |
| 4 |
AGILENT TECHNOLOGIES ISRAEL LTD
Organization address
address: EM HAMOSHAVOT ROAD 94 contact info |
IL (PETACH TIKVA) | participant | 241˙120.00 |
| 5 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 227˙513.00 |
| 6 |
KAROLINSKA INSTITUTET
Organization address
address: Nobels Vag 5 contact info |
SE (STOCKHOLM) | participant | 213˙036.00 |
| 7 |
INSTITUT PASTEUR
Organization address
address: RUE DU DOCTEUR ROUX 25-28 contact info |
FR (PARIS CEDEX 15) | participant | 186˙230.40 |
| 8 |
UNIVERSITAETSKLINIKUM HEIDELBERG
Organization address
address: IM NEUENHEIMER FELD 672 contact info |
DE (HEIDELBERG) | participant | 158˙000.00 |
| 9 |
PINTAIL LTD
Organization address
address: SPRINGHILL AVENUE 77 contact info |
IE (BLACKROCK) | participant | 127˙236.00 |
| 10 |
OSLO UNIVERSITETSSYKEHUS HF
Organization address
address: FORSKNINGSVEIEN 2B contact info |
NO (OSLO) | participant | 90˙600.00 |
| 11 |
UNIVERSITE DE MONS
Organization address
address: PLACE DU PARC 20 contact info |
BE (MONS) | participant | 84˙400.00 |
| 12 |
HUNAN UNIVERSITY
Organization address
address: LUSHAN SOUTH ROAD 1 contact info |
CN (CHANGSHA) | participant | 82˙800.00 |
| 13 |
TSINGHUA UNIVERSITY
Organization address
address: QING HUA YUAN contact info |
CN (BEIJING) | participant | 82˙800.00 |
| 14 |
BRISTOL-MYERS SQUIBB COMPANY CORP
Organization address
address: Park Avenue 345 contact info |
US (New York) | participant | 57˙572.00 |
| 15 |
KOKURITSU DAIGAKU HOJIN HOKKAIDO DAIGAKU
Organization address
address: KITA 8 NISHI 5 KITA KU contact info |
JP (SAPPORO) | participant | 0.00 |
Mappa
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Obiettivo del progetto (Objective)
'Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innovative, rapid, and high-throughput (HTP) technologies that will translate the discovery of cancer-associated glycobiomarkers from basic science to clinical application. The GlycoHIT consortium brings a highly experienced, innovative and interdisciplinary team of researchers from Europe, China and USA representing academia, industry and clinical fields to significantly enhance some of the existing glycoanalytical technologies and to advance novel HTP glycoanalytical technologies beyond current state of the art.
â–ª Microchip technology and novel partitioning methods will be exploited for nanoscale HTP separations of serum glycoproteins for analysis by HPLC or LC–MS. â–ª In parallel, lectin array technology will be radically improved by the innovative use of recombinant human lectins and lectin mimics derived by screening large phage displayed combinatorial libraries. â–ª Aptamer libraries will be exploited for identification of lectin mimics and development of a glycosignature platform â–ª Compatibility of the lectin/lectin mimic array technologies with novel label-free biosensors will be explored.
Newly-developed technologies will be validated by analysis of serum samples from a variety of cancer patient cohorts and will be supported throughout by experimental interaction analysis, complex structural modelling and informatics.
Effective project management, commercially-aware intellectual property management and targeted dissemination activities supplement the core science and ensure maximum impact for the project.'
Introduzione (Teaser)
Proteins with sugar linkages are important biomarkers of cancer. Scientists are developing novel technology for rapid and high-throughput (HTP) analysis of clinical blood samples leading to early detection and improved prognosis.
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