CHMIFLUORS

Carbohydrate Mimesis using Fluorinated Sugars for Chemical Biology: From Reaction Design to Applications in Molecular Imaging

 Coordinatore WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙253˙880 €
 EC contributo 1˙253˙880 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2013-StG
 Funding Scheme ERC-SG
 Anno di inizio 2013
 Periodo (anno-mese-giorno) 2013-11-01   -   2018-10-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

 Organization address address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149

contact info
Titolo: Dr.
Nome: Katharina
Cognome: Steinberg
Email: send email
Telefono: +49 251 83 21501

DE (MUENSTER) hostInstitution 1˙253˙880.00
2    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

 Organization address address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149

contact info
Titolo: Prof.
Nome: Ryan
Cognome: Gilmour
Email: send email
Telefono: +49 251 8333271
Fax: +49 251 8333271

DE (MUENSTER) hostInstitution 1˙253˙880.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

nmr    active    chemical    biology    envisaged    fluorinated    ubiquitous    recognition    carbohydrates    imaging    pet    validate    carbohydrate    glycostructures    molecular    mimics    fluoro   

 Obiettivo del progetto (Objective)

'The principle objective of this proposal is to validate fluorinated glyco-structures as effective carbohydrate mimics for the next frontier in pharmaceutical research. Herein we propose to capitalise on the major advances in statistical data analysis which are unravelling the complexity of mammalian and bacterial “glycospace”. Molecular mimicry is a powerful drug design approach. It is therefore envisaged to develop a focussed programme of research to validate fluorinated glycostructures, and in particular 2-fluoro sugars, as carbohydrate mimics for chemical biology, exploiting the ubiquitous role of carbohydrates in molecular recognition. Salient features of the 2-fluoro substituent include (i) enhanced hydrolytic stability to enzymatic degradation, (ii) the presence of a NMR active reporter nucleus (19F) for facile analysis, and (iii) the possibility for molecular imaging application when using 18F labelled glycostructures. Phase one of this project will aim to develop synthetic routes to the target fluoro-glycostructures. This will involve a substantial component of physical organic chemistry including conformational analysis, advanced 19F NMR spectroscopy and the possible isolation of oxo-carbenium analogues by exploiting advances in the development of large, weakly co-ordinating anions. From first principle reaction design and development, through a basic understanding of conformation and reactivity, phase 2 will focus on the application of these materials for chemical biology applications. Phase 2 will then heavily focus on the application of complex oligosaccharides containing the PET active 18F moiety. It is envisaged that by exploiting the ubiquitous role of carbohydrates in molecular recognition that this would conceivably lead to the development of selective imaging agents, thus bypassing the current problem of relying on the metabolically controlled distribution of the commonly used PET tracer 2-fluorodeoxy glucose (18F-FDG).'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

MUNATOP (2013)

Multi-Dimensional Study of non Abelian Topological States of Matter

Read More  

DROUGHT-HEAT (2014)

Land-Climate Interactions: Constraints for Droughts and Heatwaves in a Changing Climate

Read More  

RNAIEPIMOD (2009)

RNA and Epigenetics: RNAi-Driven Chromatin Modifications

Read More