SEXSEL

Investigating the joint role of balancing and positive selection in mating systems evolution

Coordinatore	AARHUS UNIVERSITET    more  Organization address address: Nordre Ringgade 1 city: AARHUS C postcode: 8000 contact info Titolo: Mr. Nome: Bjørn Vinding Cognome: Andersen Email: send email Telefono: +45 87 15 20 71
Nazionalità Coordinatore	D codicestrano [D]
Totale costo	271˙642 €
EC contributo	271˙642 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IOF
Funding Scheme	MC-IOF
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-07-01   -   2017-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	AARHUS UNIVERSITET  Organization address address: Nordre Ringgade 1 city: AARHUS C postcode: 8000 contact info Titolo: Mr. Nome: Bjørn Vinding Cognome: Andersen Email: send email Telefono: +45 87 15 20 71	DK (AARHUS C)	coordinator	271˙642.50

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 Obiettivo del progetto (Objective)

'Determining the evolutionary causes of sexual reproduction remains one of the biggest open questions in biology. Investigations of facultative sexuals can shed substantial insight on this subject due to the span of mating systems exhibited, ranging from outcrossing to asexual reproduction. Due to the widespread availability and reduced cost of sequencing technologies, it is now feasible to perform detailed genomic analysis of many individuals, and combine these data with mathematical models to determine how the underlying form of natural selection differs between asexual and sexual individuals. This genomic analysis is essential for providing insight into the evolutionary transitions between different mating systems. We propose to investigate the genetic basis of selection in asexual and sexual organisms, primarily with species of duckweeds (Lemna minor and Landoltia punctata). The initial plan will be to determine the effect of balancing selection on the evolution of recombination and outcrossing rates. Balancing selection is believed to be a widespread force in various eukaryotic genomes, and since loci exhibiting balancing selection tend to be extremely polymorphic, they should strongly influence the evolution of mating systems. After investigating this question using a multi-locus mathematical model, we will create comparative genomic methods by comparing allele and species trees to determine the extent of balancing selection in asexual and sexual organisms. We will then adapt recent mathematical theory on adaptation in selfers and outcrossers to create computational tools for detecting the extent of adaptation from novel and standing mutations, and whether the form of adaptation differs depending on the mating type.'