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MathModExp SIGNED

The Evolution of Competition and Cooperation: how polymorphisms in microbial populations optimise virulence and mediate drug resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MathModExp project word cloud

Explore the words cloud of the MathModExp project. It provides you a very rough idea of what is the project "MathModExp" about.

principles    communicate    composition    populations    antibiotics    virulence    shift    basic    nutrient    impacts    stresses    tools    species    community    polymorphic    synthesise    antibiotic    theory    predictions    multiple    overlooked    resource    polymicrobial    strains    destroy    ecology    intricate    utilise    resistance    outstanding    incorporating    fitness    food    mediated    compete    integrating    empirical    fundamental    determined    plant    vitro    genetics    predict    interactions    individual    human    life    perturb    metabolism    challenged    threatening    cooperate    antimicrobials    combination    resistant    ecological    communities    maximise    antimicrobial    physiology    pathogenicity    dynamics    will    acquire    establishing    dissect    ultimately    form    defences    understand    molecular    microbial    quantifying    players    competition    data    evolutionary    vivo    nutrients    acquisition    population    utilisation    cell    strategies    hosts    formulate    microbials    sources    theoretical    pathogens    diseases    susceptible    resilient    host    microbes   

Project "MathModExp" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙968˙392 €
 EC max contribution 1˙968˙392 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 1˙968˙392.00

Map

 Project objective

Microbes form intricate communities where multiple strains and species communicate cooperate and compete, they can cause life-threatening diseases and destroy our food sources. Metabolism is key to these interactions, yet the way microbes acquire and utilise nutrients is often overlooked in evolutionary studies of pathogenicity, virulence and antibiotic resistance. I will address this by quantifying how microbial community composition is determined by the metabolism, genetics and physiology of individual players, establishing principles by which microbial composition affects virulence and antimicrobial resistance. Competition for resources is the most basic of ecological interactions, fundamental because one cell directly impacts the fitness of others. It is only by incorporating nutrient acquisition and utilisation into studies of virulence and antibiotic resistance that we can predict, and ultimately control, the evolutionary response of microbes to resource stresses, antimicrobials and host defences. I will address two outstanding problems: Challenge one: Pathogens must acquire nutrients from their hosts, but what combination of different resource acquisition and utilisation strategies maximise population success and, therefore, virulence? Challenge two: Antibiotics can perturb the composition of polymicrobial communities from susceptible to resistant species but how is this shift mediated by resource utilisation strategies? Fully integrating empirical data and theory, concepts from ecology and evolutionary dynamics will be key. We will formulate new theoretical tools that allow us to make predictions that will be fully challenged by data, both in vitro and in vivo. This research will exploit advances in the molecular genetics of important plant and human pathogens and we will use them to synthesise polymorphic microbial populations and polymicrobial communities. We will dissect these to understand what makes microbials so resilient to the challenges they face.

 Publications

year authors and title journal last update
List of publications.
2019 Richard J. Lindsay, Bogna J. Pawlowska, Ivana Gudelj
Privatization of public goods can cause population decline
published pages: 1206-1216, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0944-9
Nature Ecology & Evolution 3/8 2020-04-03
2016 Ivana Gudelj, Margie Kinnersley, Peter Rashkov, Karen Schmidt, Frank Rosenzweig
Stability of Cross-Feeding Polymorphisms in Microbial Communities
published pages: e1005269, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005269
PLOS Computational Biology 12/12 2019-06-05
2018 Richard J. Lindsay, Bogna J. Pawlowska, Ivana Gudelj
When increasing population density can promote the evolution of metabolic cooperation
published pages: 849-859, ISSN: 1751-7362, DOI: 10.1038/s41396-017-0016-6
The ISME Journal 12/3 2019-06-05
2016 Richard J Lindsay, Michael J Kershaw, Bogna J Pawlowska, Nicholas J Talbot, Ivana Gudelj
Harbouring public good mutants within a pathogen population can increase both fitness and virulence
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.18678
eLife 5 2019-06-05
2017 Carlos Reding-Roman, Mark Hewlett, Sarah Duxbury, Fabio Gori, Ivana Gudelj, Robert Beardmore
The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes
published pages: 50, ISSN: 2397-334X, DOI: 10.1038/s41559-016-0050
Nature Ecology & Evolution 1/3 2019-06-05
2018 Robert E. Beardmore, Emily Cook, Susanna Nilsson, Adam R. Smith, Anna Tillmann, Brooke D. Esquivel, Ken Haynes, Neil A. R. Gow, Alistair J. P. Brown, Theodore C. White, Ivana Gudelj
Drug-mediated metabolic tipping between antibiotic resistant states in a mixed-species community
published pages: 1312-1320, ISSN: 2397-334X, DOI: 10.1038/s41559-018-0582-7
Nature Ecology & Evolution 2/8 2019-06-05

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