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Social Distress Response in the Context of Empathy in Rats

Total Cost €


EC-Contrib. €






 SOCIORATS project word cloud

Explore the words cloud of the SOCIORATS project. It provides you a very rough idea of what is the project "SOCIORATS" about.

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Project "SOCIORATS" data sheet

The following table provides information about the project.


Organization address
postcode: 1011 JV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

'Why do humans behave pro-socially to such an extent that it supports the life of other individuals? Similarly, why do certain people harm others by hurting and sometimes killing? Finally, how can we promote pro-sociality and limit harmful actions? The philosopher and economist Adam Smith considered that what motivates us to help a person is that we can “place ourselves in his situation, we conceive ourselves enduring all the same torments', thus, holding empathy as the driving force of prosociality. Human neuroimaging studies show that two brain structures, the anterior insula (AI) and the rostral cingulate cortex (rCC), are involved in empathy. Yet, it remains unknown whether these structures are involved in consequent behaviors, i.e., helping or hurting others. With this fellowship, I intend to fill this gap: I propose an approach to causally test Adam Smith's theory, which will produce findings of tangible societal benefits by informing populations worldwide whether prosocial programs can limit fighting and bullying, and by providing novel pharmacological targets for the treatment anti-social disorders.

Because human neuroimaging is severely limited in its ability to establish causal links between brain activity and behavior, we will use a rat model to study empathy-driven prosociality. Considering that a suited rodent model is completely lacking in the field, we will develop a paradigm where actor rats choose between two levers; while both yield the same reward, one requires more effort to be activated. Once preference for the easy lever has been quantified, it will be paired with an electric shock delivered to another rat. The impact of social distress on the actor's choice will provide a way to study prosocial and aggressive behavior. In a second time, we will deactivate the rCC and AI in order to causally explore the role of each structure in prosociality. Finally, we will use calcium-imaging to map and characterize the neural networks involved.'

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The information about "SOCIORATS" are provided by the European Opendata Portal: CORDIS opendata.

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