EVESTEMINJURY

Extracellular Vesicles and exosomes from adult stem cells in the regeneration of organ injury

Coordinatore	FRESENIUS MEDICAL CARE ITALIA SPA    more  Organization address address: VIA CREMA 8 city: PALAZZO PIGNANO postcode: 26020 contact info Titolo: Dr. Nome: Ciro Cognome: Tetta Email: send email Telefono: +39 335 78 69 152
Nazionalità Coordinatore	Italy [IT]
Totale costo	1˙249˙747 €
EC contributo	1˙249˙747 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-IAPP
Funding Scheme	MC-IAPP
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-02-01   -   2018-01-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FRESENIUS MEDICAL CARE ITALIA SPA  Organization address address: VIA CREMA 8 city: PALAZZO PIGNANO postcode: 26020 contact info Titolo: Dr. Nome: Ciro Cognome: Tetta Email: send email Telefono: +39 335 78 69 152	IT (PALAZZO PIGNANO)	coordinator	542˙022.00
2	UNIVERSITAIR MEDISCH CENTRUM UTRECHT  Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX contact info Titolo: Dr. Nome: Raymond M Cognome: Schiffelers Email: send email Telefono: +31 887556512	NL (UTRECHT)	participant	272˙085.64
3	LONDON METROPOLITAN UNIVERSITY  Organization address address: Holloway Road 166-220 city: LONDON postcode: N7 8DB contact info Titolo: Prof. Nome: Jameel Cognome: Inal Email: send email Telefono: +44 2071332122	UK (LONDON)	participant	257˙404.40
4	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER  Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 contact info Titolo: Dr. Nome: Pastora Cognome: Martinez Samper Email: send email Telefono: +34 932275707 Fax: +34 932279205	ES (BARCELONA)	participant	178˙235.19

Mappa

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 Obiettivo del progetto (Objective)

'Acute and chronic kidney disease is a worldwide medical and public health problem in all developped and undevelopped Countries. It is clear that a large part of the bad outcome of end-stage renal diseas (ESRD) patients is due to deficient follow-up during the earlier chronic kidney disease (CKD) stages. The concept that extracellular vesicles and exosomes (EVs) by transferring extracellular RNAs can modulate the phenotype of target cells is an emerging paradigm in the intercellular communication. The extracellular RNAs are thus now considered as paracrine/endocrine signals. EVs contain diverse species of RNAs (mRNA, miRNAs and long non-coding RNAs) reflecting the functional state of the cell of origin. Recent studies on adult stem cell-induced tissue regeneration pointed out paracrine/endocrine mechanisms rather than permanent engraftment and trans-differentiation of stem cells. Therefore, the paracrine/endocrine hypothesis has changed the perspective of the therapeutic use of stem cells in regenerative medicine. Additionally, several studies indicate that EVs play a relevant role as mediators of stem cell induced regeneration by reprogramming injured cells. Within this project, we will explore the different necessary aspects in order to get a more profound knowledge on EVs, on their mechanisms of action in tissue injury, and on the definition of the most promising “active biological ingredients” of their content to further promote EV as new potential therapeutic strategies in the field of regenerative medicine. Also, within the EVStemInjury project, two different approaches of EV production will be explored: Biological and Synthetic, showing the different potential design strategies and to assess their efficiency. Finally, in order to explore the renoprotective effect of EVs, developed within the project, ranging from toxic, ischemic and reperfusion models, we will use a large number of experimental in vitro as in vivo models of acute kidney injury.'