MEMSTICK

Synaptic mechanisms of memory loss: novel cell adhesion molecules as therapeutic targets

 Coordinatore ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Carmen
Cognome: Sandi
Email: send email
Telefono: +41 21 693 9534
Fax: +41 21 693 53 50

 Nazionalità Coordinatore Switzerland [CH]
 Sito del progetto http://www.memstick.org/
 Totale costo 4˙138˙676 €
 EC contributo 2˙970˙372 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-02-01   -   2011-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

 Organization address address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015

contact info
Titolo: Prof.
Nome: Carmen
Cognome: Sandi
Email: send email
Telefono: +41 21 693 9534
Fax: +41 21 693 53 50

CH (LAUSANNE) coordinator 0.00
2    AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

 Organization address address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
Nome: Mar
Cognome: Garcia Ferrer
Email: send email
Telefono: 34 91 585 50 00
Fax: +34 91 411 3077

ES (MADRID) participant 0.00
3    ENKAM PHARMACEUTICALS A/S

 Organization address address: "Fruebjergvej, 3"
city: COPENHAGEN
postcode: 2100

contact info
Titolo: Prof.
Nome: Vladimir
Cognome: Berezin
Email: send email
Telefono: +45-35 32 73 35
Fax: +45-39 17 97 14

DK (COPENHAGEN) participant 0.00
4    INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK

 Organization address address: UL. LUDWIKA PASTEURA 3
city: WARSZAWA
postcode: 02 093

contact info
Titolo: Dr.
Nome: Marcin
Cognome: Szumowski
Email: send email
Telefono: +48 22 589 22 63
Fax: +48 22 589 24 89

PL (WARSZAWA) participant 0.00
5    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Tine
Cognome: Heylen
Email: send email
Telefono: +32 16 326520
Fax: +31 16 326515

BE (LEUVEN) participant 0.00
6    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Nome: Hartmut
Cognome: Lingner
Email: send email
Telefono: +49 89 306 22330
Fax: +49 89 306 22372

DE (MUENCHEN) participant 0.00
7    NEOLOCH PHARMACEUTICALS APS

 Organization address address: Tjornekrogen 5
city: GENTOFTE
postcode: 2820

contact info
Titolo: Prof.
Nome: Elisabeth
Cognome: Bock
Email: send email
Telefono: 4526289456
Fax: 4535360116

DK (GENTOFTE) participant 0.00
8    SCIPROM SARL

 Organization address address: RUE DU CENTRE 70
city: Saint-Sulpice
postcode: 1025

contact info
Titolo: Dr.
Nome: Kirsten
Cognome: Leufgen
Email: send email
Telefono: +41 21 693 02 61
Fax: -

CH (Saint-Sulpice) participant 0.00
9    THE OPEN UNIVERSITY

 Organization address address: WALTON HALL
city: MILTON KEYNES
postcode: MK7 6AA

contact info
Titolo: Prof.
Nome: Michael
Cognome: Stewart
Email: send email
Telefono: +44-1908 653448
Fax: +44-1908 65417

UK (MILTON KEYNES) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

loss    deficits    cams    prevent    molecular    domains    synaptic    molecules    decline    treat    drugs    memory    neurobiological    disease   

 Obiettivo del progetto (Objective)

'Memory loss is a central symptom in different diseases, and represents a significant social and economic burden for a large percentage of European citizens. The molecular and neurobiological bases of memory deficits are largely unknown and there are currently no drugs available that can markedly decelerate or prevent memory decline. To address this major problem, this project will investigate the role of novel synaptic cell adhesion molecules (CAMs) in memory loss, and the therapeutic value of targeting these CAMs to restore memory function and associated neurobiological mechanisms at the synaptic level. The selection of novel synaptic CAMs is based on (1) recent evidence showing that they can recruit the synaptic machinery and form synapses; (2) the implication of CAMs, in general, in synaptic plasticity and memory, and (3) a direct link established between synaptic remodelling and memory formation. We have assembled a multidisciplinary consortium including excellent European researchers in this field, covering a wide range of structural, biochemical, electrophysiological and behavioural expertise. To understand memory loss, three domains have been selected as among the most prominent and widespread disease domains affecting memory and quality of life in our society: psychiatric disorders, the neurodegenerative disorder of Alzheimer's disease, stress and aging. For each disease domain, specific and validated animal models will be used to investigate memory loss on molecular, subcellular, cellular and functional levels. Our approach will result in the preclinical development and validation of mimetic peptides for novel synaptic CAMs as potential drug candidates to treat memory deficits or prevent memory decline. The current proposal offers the groundbreaking possibility to raise the bar in memory research by targeting novel molecules and developing effective drugs to treat memory disturbances based on their biological mechanism.'

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